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Protein

Conantokin-Oc

Gene
N/A
Organism
Conus ochroleucus (Perfect cone) (Graphiconus ochroleucus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors.By similarity

Miscellaneous

The mature peptide does not contain cysteine residue.Curated

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Ionotropic glutamate receptor inhibitor, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conantokin-Oc1 Publication
Short name:
Con-Oc1 Publication
OrganismiConus ochroleucus (Perfect cone) (Graphiconus ochroleucus)
Taxonomic identifieri72282 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPhasmoconus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00004395191 – 22Conantokin-OcAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34-carboxyglutamate1 Publication1
Modified residuei44-carboxyglutamate1 Publication1
Modified residuei104-carboxyglutamate1 Publication1
Modified residuei184-carboxyglutamate1 Publication1

Keywords - PTMi

Gamma-carboxyglutamic acid

Expressioni

Tissue specificityi

Expressed by the venom duct.Curated

Sequencei

Sequence statusi: Complete.

P0DP00-1 [UniParc]FASTAAdd to basket
« Hide
        10         20 
GEEERKAMAE LEAKKAQEAL KA
Length:22
Mass (Da):2,431
Last modified:April 12, 2017 - v1
Checksum:i3F56DA9858EEEBEA
GO

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCKO_CONOH
AccessioniPrimary (citable) accession number: P0DP00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2017
Last sequence update: April 12, 2017
Last modified: September 12, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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