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Conotoxin Asi14a

Conus asiaticus (Cone snail)
Reviewed-Annotation score: -Experimental evidence at protein leveli


May have neurotoxic activities (Probable). Does not show any effect on voltage-gated potassium channels (10 µM of toxin tested), and on nicotinic acetylcholine receptors (5 µM of toxin tested) (PubMed:27801785). Does not show antibacterial activity on both Gram-negative and Gram-positive bacteria (PubMed:27801785).Curated1 Publication


Does not show effect on Kv1.1, Kv1.2, Kv1.3, Kv1.4, Kv1.5, and Kv1.6 (PubMed:27801785). Does not show effect on muscular (alpha-1-beta-1-delta-epsilon) and neuronal alpha-7, alpha-4-beta-4, and alpha-3-beta-4 nAChRs (PubMed:27801785).1 Publication

GO - Molecular functioni


Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Asi14a1 Publication
OrganismiConus asiaticus (Cone snail)
Taxonomic identifieri1945508 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPhasmoconus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti


PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00004395181 – 17Conotoxin Asi14a1 PublicationAdd BLAST17

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17Glycine amide1 Publication1

Post-translational modificationi

Contains 2 disulfide bonds.1 Publication

Keywords - PTMi

Amidation, Disulfide bond


Tissue specificityi

Expressed by the venom duct.1 Publication

Family & Domainsi


The cysteine framework is XIV (C-C-C-C).Curated


Sequence statusi: Complete.

Mass (Da):1,701
Last modified:April 12, 2017 - v1

Mass spectrometryi

Molecular mass is 1697.6 Da from positions 1 - 17. Determined by MALDI. 1 Publication

Entry informationi

Entry nameiCUEA_CONAX
AccessioniPrimary (citable) accession number: P0DOZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2017
Last sequence update: April 12, 2017
Last modified: September 12, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program


Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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