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Immunoglobulin heavy diversity 1-1



Homo sapiens (Human)
Reviewed-Annotation score: -Protein predictedi


D region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).4 Publications


There are several genes encoding the D region in the immunoglobulin heavy locus. The peptide described in this entry is a representative for all the peptides encoded by these genes. For examples of full-length immunoglobulin heavy chains (of different isotypes) see AC P0DOX2, AC P0DOX3, AC P0DOX4, AC P0DOX5 and AC P0DOX6.Curated

GO - Biological processi


Biological processAdaptive immunity, Immunity

Protein family/group databases


Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin heavy diversity 1-12 Publications
Gene namesi
Name:IGHD1-12 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases


Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000439097‹1 – ›5Immunoglobulin heavy diversity 1-1›5


Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication


Sequence statusi: Complete.

Mass (Da):435
Last modified:March 15, 2017 - v1

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei51


The sequence shown is that of IMGT allele IGHD1-1*01.Curated

Sequence databases

Select the link destinations:
Links Updated
AC246787 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000454908; ENSP00000418625; ENSG00000236170
ENST00000633210; ENSP00000488840; ENSG00000282714

Keywords - Coding sequence diversityi


Entry informationi

Entry nameiHD101_HUMAN
AccessioniPrimary (citable) accession number: P0DOY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: March 15, 2017
Last modified: October 25, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.


Keywords - Technical termi

Complete proteome, Reference proteome


  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM

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