UniProtKB - P0DOY2 (IGLC2_HUMAN)
Protein
Immunoglobulin lambda constant 2
Gene
IGLC2
Organism
Homo sapiens (Human)
Status
Functioni
Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).3 Publications
Miscellaneous
Displays the following serological isotype: Mcg-, Kern- and Oz-. The Mcg- isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz- marker by Arg-83.1 Publication
Caution
For an example of a full-length immunoglobulin lambda light chain see AC P0DOX8.Curated
GO - Molecular functioni
- antigen binding Source: GO_Central
- immunoglobulin receptor binding Source: GO_Central
GO - Biological processi
- B cell receptor signaling pathway Source: GO_Central
- complement activation Source: Reactome
- complement activation, classical pathway Source: GO_Central
- defense response to bacterium Source: GO_Central
- Fc-epsilon receptor signaling pathway Source: Reactome
- Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
- innate immune response Source: GO_Central
- leukocyte migration Source: Reactome
- phagocytosis, engulfment Source: GO_Central
- phagocytosis, recognition Source: GO_Central
- positive regulation of B cell activation Source: GO_Central
- receptor-mediated endocytosis Source: Reactome
- regulation of complement activation Source: Reactome
- regulation of immune response Source: Reactome
Keywordsi
Molecular function | Bence-Jones protein |
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | P0DOY2 |
Reactomei | R-HSA-166663, Initial triggering of complement R-HSA-173623, Classical antibody-mediated complement activation R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-2029481, FCGR activation R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485, Role of phospholipids in phagocytosis R-HSA-2168880, Scavenging of heme from plasma R-HSA-2454202, Fc epsilon receptor (FCERI) signaling R-HSA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796, FCERI mediated MAPK activation R-HSA-2871809, FCERI mediated Ca+2 mobilization R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-5690714, CD22 mediated BCR regulation R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-9664422, FCGR3A-mediated phagocytosis R-HSA-977606, Regulation of Complement cascade R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Protein family/group databases
IMGT/GENE-DB | IGLC2 |
Names & Taxonomyi
Protein namesi | Recommended name: Immunoglobulin lambda constant 22 PublicationsAlternative name(s): Ig lambda chain C region Kern1 Publication Ig lambda chain C region NIG-641 Publication Ig lambda chain C region SH1 Publication Ig lambda chain C region X1 Publication Ig lambda-2 chain C regionCurated |
Gene namesi | Name:IGLC22 Publications |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000211677.2 |
HGNCi | HGNC:5856, IGLC2 |
neXtProti | NX_P0DOY2 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
- immunoglobulin complex, circulating Source: GO_Central
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Keywords - Cellular componenti
Cell membrane, Immunoglobulin, Membrane, SecretedPathology & Biotechi
Miscellaneous databases
Pharosi | P0DOY2, Tdark |
Polymorphism and mutation databases
BioMutai | IGLC2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000394665 | ‹1 – 106 | Immunoglobulin lambda constant 2Add BLAST | ›106 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 28 ↔ 87 | PROSITE-ProRule annotation | ||
Disulfide bondi | 105 | Interchain (with heavy chain)1 Publication |
Keywords - PTMi
Disulfide bondProteomic databases
jPOSTi | P0DOY2 |
MassIVEi | P0DOY2 |
MaxQBi | P0DOY2 |
PeptideAtlasi | P0DOY2 |
PRIDEi | P0DOY2 |
PTM databases
CarbonylDBi | P0DOY2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000211677, Expressed in tonsil and 111 other tissues |
Interactioni
Subunit structurei
Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
1 PublicationGO - Molecular functioni
- immunoglobulin receptor binding Source: GO_Central
Protein-protein interaction databases
IntActi | P0DOY2, 7 interactors |
Miscellaneous databases
RNActi | P0DOY2, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0DOY2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 101 | Ig-likePROSITE-ProRule annotationAdd BLAST | 95 |
Keywords - Domaini
Immunoglobulin domainPhylogenomic databases
PhylomeDBi | P0DOY2 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
P0DOY2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
GQPKAAPSVT LFPPSSEELQ ANKATLVCLI SDFYPGAVTV AWKADSSPVK
60 70 80 90 100
AGVETTTPSK QSNNKYAASS YLSLTPEQWK SHRSYSCQVT HEGSTVEKTV
APTECS
Sequence cautioni
The sequence AAA59107 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA20026 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA36049 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAB38569 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence EAW59547 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence EAW59549 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Polymorphismi
There are several alleles. The sequence shown is that of IMGT allele IGLC2*02.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00253 Genomic DNA Translation: AAA59107.1 Different initiation. X51754 Genomic DNA Translation: CAB38569.1 Different initiation. X51755 Genomic DNA Translation: CAA36049.1 Different initiation. D87023 Genomic DNA Translation: BAA20026.1 Different initiation. AC245028 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW59547.1 Different initiation. CH471095 Genomic DNA Translation: EAW59549.1 Different initiation. |
PIRi | A92057, L2HU |
Genome annotation databases
Ensembli | ENST00000390323; ENSP00000374856; ENSG00000211677 |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00253 Genomic DNA Translation: AAA59107.1 Different initiation. X51754 Genomic DNA Translation: CAB38569.1 Different initiation. X51755 Genomic DNA Translation: CAA36049.1 Different initiation. D87023 Genomic DNA Translation: BAA20026.1 Different initiation. AC245028 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW59547.1 Different initiation. CH471095 Genomic DNA Translation: EAW59549.1 Different initiation. |
PIRi | A92057, L2HU |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1JVK | X-ray | 1.94 | B | 1-105 | [»] | |
1LIL | X-ray | 2.65 | A/B | 1-106 | [»] | |
1ZVO | X-ray | - | A/B | 2-106 | [»] | |
2JB5 | X-ray | 2.80 | L | 1-104 | [»] | |
2JB6 | X-ray | 2.85 | A/L | 1-104 | [»] | |
3C2A | X-ray | 2.10 | L/M | 2-105 | [»] | |
3TV3 | X-ray | 1.29 | L | 1-106 | [»] | |
3TWC | X-ray | 1.65 | L | 1-106 | [»] | |
3TYG | X-ray | 3.25 | L | 1-106 | [»] | |
4EOW | X-ray | 1.97 | L | 1-106 | [»] | |
4LLD | X-ray | 1.19 | B | 1-105 | [»] | |
4LLM | X-ray | 1.75 | B | 1-105 | [»] | |
4LLQ | X-ray | 1.42 | B | 1-105 | [»] | |
4LLU | X-ray | 2.16 | B/D | 1-105 | [»] | |
4LLW | X-ray | 1.95 | B/D | 1-105 | [»] | |
4LLY | X-ray | 1.60 | B/D | 1-105 | [»] | |
4O58 | X-ray | 2.75 | L | 1-106 | [»] | |
4O5I | X-ray | 6.50 | N/P/R/T/V/X | 1-106 | [»] | |
5IQ7 | X-ray | 3.29 | L | 1-104 | [»] | |
5IQ9 | X-ray | 2.40 | B/L | 1-102 | [»] | |
6DE7 | X-ray | 4.12 | L | 1-106 | [»] | |
6UMX | X-ray | 2.79 | L/l | 1-106 | [»] | |
SMRi | P0DOY2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P0DOY2, 7 interactors |
Protein family/group databases
IMGT/GENE-DB | IGLC2 |
PTM databases
CarbonylDBi | P0DOY2 |
Polymorphism and mutation databases
BioMutai | IGLC2 |
Proteomic databases
jPOSTi | P0DOY2 |
MassIVEi | P0DOY2 |
MaxQBi | P0DOY2 |
PeptideAtlasi | P0DOY2 |
PRIDEi | P0DOY2 |
Genome annotation databases
Ensembli | ENST00000390323; ENSP00000374856; ENSG00000211677 |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000211677.2 |
GeneCardsi | IGLC2 |
HGNCi | HGNC:5856, IGLC2 |
neXtProti | NX_P0DOY2 |
GenAtlasi | Search... |
Phylogenomic databases
PhylomeDBi | P0DOY2 |
Enzyme and pathway databases
PathwayCommonsi | P0DOY2 |
Reactomei | R-HSA-166663, Initial triggering of complement R-HSA-173623, Classical antibody-mediated complement activation R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-2029481, FCGR activation R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485, Role of phospholipids in phagocytosis R-HSA-2168880, Scavenging of heme from plasma R-HSA-2454202, Fc epsilon receptor (FCERI) signaling R-HSA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796, FCERI mediated MAPK activation R-HSA-2871809, FCERI mediated Ca+2 mobilization R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-5690714, CD22 mediated BCR regulation R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-9664422, FCGR3A-mediated phagocytosis R-HSA-977606, Regulation of Complement cascade R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Miscellaneous databases
ChiTaRSi | IGLC2, human |
Pharosi | P0DOY2, Tdark |
PROi | PR:P0DOY2 |
RNActi | P0DOY2, protein |
Gene expression databases
Bgeei | ENSG00000211677, Expressed in tonsil and 111 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IGLC2_HUMAN | |
Accessioni | P0DOY2Primary (citable) accession number: P0DOY2 Secondary accession number(s): A0A075B6K9 P80423 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2017 |
Last sequence update: | March 15, 2017 | |
Last modified: | August 12, 2020 | |
This is version 23 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM