Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Immunoglobulin kappa light chain

Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).3 Publications

Caution

This sequence is an example of a full-length immunoglobulin kappa light chain.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin kappa light chainCurated
Alternative name(s):
Immunoglobulin kappa light chain EU1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004392881 – 214Immunoglobulin kappa light chainAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 88PROSITE-ProRule annotation1 Publication
Disulfide bondi134 ↔ 194PROSITE-ProRule annotation1 Publication
Disulfide bondi214Interchain (with a heavy chain)1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PeptideAtlasiP0DOX7
PRIDEiP0DOX7

PTM databases

CarbonylDBiP0DOX7

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Structurei

3D structure databases

SMRiP0DOX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 99Ig-like 1PROSITE-ProRule annotationAdd BLAST98
Domaini113 – 210Ig-like 2PROSITE-ProRule annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 108Variable (V) domain, involved in antigen recognitionCuratedAdd BLAST108
Regioni109 – 214Constant (C) domainCuratedAdd BLAST106

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Immunoglobulin V region, Repeat

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00407 IGc1, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

P0DOX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DIQMTQSPST LSASVGDRVT ITCRASQSIN TWLAWYQQKP GKAPKLLMYK
60 70 80 90 100
ASSLESGVPS RFIGSGSGTE FTLTISSLQP DDFATYYCQQ YNSDSKMFGQ
110 120 130 140 150
GTKVEVKGTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV
160 170 180 190 200
DNALQSGNSQ ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG
210
LSSPVTKSFN RGEC
Length:214
Mass (Da):23,379
Last modified:March 15, 2017 - v1
Checksum:i8DF29E176EFE0BB4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Entry informationi

Entry nameiIGK_HUMAN
AccessioniPrimary (citable) accession number: P0DOX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: March 15, 2017
Last modified: July 18, 2018
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health