Immunoglobulin gamma-1 heavy chain

Functionⁱ

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).3 Publications

Caution

This sequence is an example of a full-length immunoglobulin gamma-1 heavy chain.Curated

GO - Molecular functionⁱ

antigen binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Adaptive immunity, Immunity

Biological process

Adaptive immunity, Immunity

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Immunoglobulin gamma-1 heavy chainCurated Alternative name(s): Immunoglobulin gamma-1 heavy chain NIE1 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000439287	1 – 449	Immunoglobulin gamma-1 heavy chainAdd BLAST		449

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	Pyrrolidone carboxylic acid1 Publication	1
Disulfide bondⁱ	22 ↔ 96	1 Publication
Glycosylationⁱ	73	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	146 ↔ 202	1 Publication
Disulfide bondⁱ	222	Interchain (with light chain)1 Publication
Disulfide bondⁱ	228	Interchain (with heavy chain)1 Publication
Disulfide bondⁱ	231	Interchain (with heavy chain)1 Publication
Disulfide bondⁱ	263 ↔ 323	1 Publication
Glycosylationⁱ	299	N-linked (GlcNAc...) (complex) asparagine1 Publication	1
Disulfide bondⁱ	369 ↔ 427	1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P0DOX5
PRIDEⁱ	P0DOX5

PTM databases

CarbonylDBⁱ	P0DOX5
iPTMnetⁱ	P0DOX5

Interactionⁱ

Subunit structureⁱ

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	3 – 7	Combined sources	5
Beta strandⁱ	10 – 12	Combined sources	3
Beta strandⁱ	18 – 27	Combined sources	10
Helixⁱ	29 – 31	Combined sources	3
Beta strandⁱ	34 – 39	Combined sources	6
Beta strandⁱ	46 – 51	Combined sources	6
Beta strandⁱ	53 – 55	Combined sources	3
Turnⁱ	62 – 64	Combined sources	3
Beta strandⁱ	68 – 73	Combined sources	6
Turnⁱ	74 – 77	Combined sources	4
Beta strandⁱ	78 – 83	Combined sources	6
Helixⁱ	88 – 90	Combined sources	3
Beta strandⁱ	92 – 97	Combined sources	6
Beta strandⁱ	113 – 117	Combined sources	5
Beta strandⁱ	126 – 130	Combined sources	5
Beta strandⁱ	134 – 136	Combined sources	3
Beta strandⁱ	141 – 154	Combined sources	14
Beta strandⁱ	157 – 160	Combined sources	4
Turnⁱ	161 – 164	Combined sources	4
Beta strandⁱ	169 – 171	Combined sources	3
Beta strandⁱ	182 – 191	Combined sources	10
Helixⁱ	192 – 194	Combined sources	3
Turnⁱ	195 – 197	Combined sources	3
Beta strandⁱ	201 – 206	Combined sources	6
Helixⁱ	207 – 209	Combined sources	3
Beta strandⁱ	211 – 216	Combined sources	6
Beta strandⁱ	241 – 245	Combined sources	5
Helixⁱ	249 – 253	Combined sources	5
Beta strandⁱ	255 – 257	Combined sources	3
Beta strandⁱ	260 – 268	Combined sources	9
Beta strandⁱ	270 – 272	Combined sources	3
Beta strandⁱ	276 – 281	Combined sources	6
Beta strandⁱ	284 – 286	Combined sources	3
Beta strandⁱ	289 – 291	Combined sources	3
Beta strandⁱ	295 – 297	Combined sources	3
Turnⁱ	298 – 300	Combined sources	3
Beta strandⁱ	302 – 309	Combined sources	8
Helixⁱ	312 – 316	Combined sources	5
Beta strandⁱ	321 – 326	Combined sources	6
Beta strandⁱ	330 – 332	Combined sources	3
Beta strandⁱ	334 – 338	Combined sources	5
Beta strandⁱ	349 – 353	Combined sources	5
Helixⁱ	357 – 361	Combined sources	5
Beta strandⁱ	362 – 377	Combined sources	16
Beta strandⁱ	380 – 385	Combined sources	6
Beta strandⁱ	388 – 390	Combined sources	3
Beta strandⁱ	393 – 395	Combined sources	3
Beta strandⁱ	406 – 415	Combined sources	10
Helixⁱ	416 – 420	Combined sources	5
Beta strandⁱ	425 – 430	Combined sources	6
Helixⁱ	435 – 437	Combined sources	3
Beta strandⁱ	438 – 443	Combined sources	6

Show more details

3D structure databases

SMRⁱ	P0DOX5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 96	Ig-like 1PROSITE-ProRule annotationAdd BLAST	96
Domainⁱ	125 – 218	Ig-like 2PROSITE-ProRule annotationAdd BLAST	94
Domainⁱ	240 – 339	Ig-like 3PROSITE-ProRule annotationAdd BLAST	100
Domainⁱ	348 – 444	Ig-like 4PROSITE-ProRule annotationAdd BLAST	97

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 119	Variable (V) domain, involved in antigen recognitionCuratedAdd BLAST		119
Regionⁱ	120 – 449	Constant (C) domainCuratedAdd BLAST		330

Keywords - Domainⁱ

Immunoglobulin C region, Immunoglobulin domain, Immunoglobulin V region, Repeat

Family and domain databases

Gene3Dⁱ	2.60.40.10, 4 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR003599 Ig_sub IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654 C1-set, 3 hits PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits SM00407 IGc1, 3 hits SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 4 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 4 hits PS00290 IG_MHC, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

P0DOX5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
QVQLVQSGGG VVQPGRSLRL SCAASGFTFS RYTIHWVRQA PGKGLEWVAV 
        60         70         80         90        100
MSYNGNNKHY ADSVNGRFTI SRNDSKNTLY LNMNSLRPED TAVYYCARIR 
       110        120        130        140        150
DTAMFFAHWG QGTLVTVSSA STKGPSVFPL APSSKSTSGG TAALGCLVKD 
       160        170        180        190        200
YFPEPVTVSW NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY 
       210        220        230        240        250
ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK 
       260        270        280        290        300
DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS 
       310        320        330        340        350
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV 
       360        370        380        390        400
YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL 
       410        420        430        440 
DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK

Length:449

Mass (Da):49,329

Last modified:July 18, 2018 - v2

Checksum:ⁱA7943E4D7C559ACE

GO

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P0DOX5	Immunoglobulin heavy constant gamma 1	)	HUMAN		330	UniRef50_P01857
Uncharacterized protein (Fragment)		AILME		424
Anti-dectin-1 15E2 heavy chain		MOUSE		469
Macaca fascicularis brain cDNA clone: QmoA-12188, similar to human similar to FLJ27099 protein (LOC388078), mRNA, RefSeq: XM_370835.1		MACFA		433
Uncharacterized protein		PAPAN		107
+76

Entry informationⁱ

Entry nameⁱ	IGG1_HUMAN
Accessionⁱ	P0DOX5Primary (citable) accession number: P0DOX5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 15, 2017
	Last sequence update:	July 18, 2018
	Last modified:	September 12, 2018
	This is version 14 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing

UniProtKB - P0DOX5 (IGG1_HUMAN)

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Functionⁱ

Caution

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Extracellular region or secreted

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

Interactionⁱ

Subunit structureⁱ

Structureⁱ

Secondary structure

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Region

Keywords - Domainⁱ

Family and domain databases

Sequenceⁱ

Similar proteinsⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0DOX5 (IGG1_HUMAN)

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Immunoglobulin gamma-1 heavy chain

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ