UniProtKB - P0DOX5 (IGG1_HUMAN)
Protein
Immunoglobulin gamma-1 heavy chain
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).3 Publications
Caution
This sequence is an example of a full-length immunoglobulin gamma-1 heavy chain.Curated
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
Keywordsi
Biological process | Adaptive immunity, Immunity |
Names & Taxonomyi
Protein namesi | Recommended name: Immunoglobulin gamma-1 heavy chainCuratedAlternative name(s): Immunoglobulin gamma-1 heavy chain NIE1 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- immunoglobulin complex Source: UniProtKB-KW
Keywords - Cellular componenti
Cell membrane, Immunoglobulin, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000439287 | 1 – 449 | Immunoglobulin gamma-1 heavy chainAdd BLAST | 449 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | Pyrrolidone carboxylic acid1 Publication | 1 | |
Disulfide bondi | 22 ↔ 96 | 1 Publication | ||
Glycosylationi | 73 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 146 ↔ 202 | 1 Publication | ||
Disulfide bondi | 222 | Interchain (with light chain)1 Publication | ||
Disulfide bondi | 228 | Interchain (with heavy chain)1 Publication | ||
Disulfide bondi | 231 | Interchain (with heavy chain)1 Publication | ||
Disulfide bondi | 263 ↔ 323 | 1 Publication | ||
Glycosylationi | 299 | N-linked (GlcNAc...) (complex) asparagine1 Publication | 1 | |
Disulfide bondi | 369 ↔ 427 | 1 Publication |
Keywords - PTMi
Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acidProteomic databases
EPDi | P0DOX5 |
jPOSTi | P0DOX5 |
MassIVEi | P0DOX5 |
PeptideAtlasi | P0DOX5 |
PRIDEi | P0DOX5 |
PTM databases
CarbonylDBi | P0DOX5 |
iPTMneti | P0DOX5 |
Interactioni
Subunit structurei
Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0DOX5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 96 | Ig-like 1PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 125 – 218 | Ig-like 2PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 240 – 339 | Ig-like 3PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 348 – 444 | Ig-like 4PROSITE-ProRule annotationAdd BLAST | 97 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 119 | Variable (V) domain, involved in antigen recognitionCuratedAdd BLAST | 119 | |
Regioni | 120 – 449 | Constant (C) domainCuratedAdd BLAST | 330 |
Keywords - Domaini
Immunoglobulin domain, RepeatFamily and domain databases
Gene3Di | 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07654, C1-set, 3 hits PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00407, IGc1, 3 hits SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 4 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 4 hits PS00290, IG_MHC, 2 hits |
i Sequence
Sequence statusi: Complete.
P0DOX5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
QVQLVQSGGG VVQPGRSLRL SCAASGFTFS RYTIHWVRQA PGKGLEWVAV
60 70 80 90 100
MSYNGNNKHY ADSVNGRFTI SRNDSKNTLY LNMNSLRPED TAVYYCARIR
110 120 130 140 150
DTAMFFAHWG QGTLVTVSSA STKGPSVFPL APSSKSTSGG TAALGCLVKD
160 170 180 190 200
YFPEPVTVSW NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY
210 220 230 240 250
ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK
260 270 280 290 300
DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
310 320 330 340 350
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV
360 370 380 390 400
YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL
410 420 430 440
DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
Similar proteinsi
Cross-referencesi
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5O4E | X-ray | 2.15 | A | 227-449 | [»] | |
C | 227-448 | [»] | ||||
5VJ6 | electron microscopy | 11.50 | H | 3-224 | [»] | |
5VU0 | X-ray | 2.26 | A/B | 230-446 | [»] | |
5VZX | X-ray | 2.50 | E/H | 1-227 | [»] | |
5VZY | X-ray | 2.32 | H | 1-227 | [»] | |
5W5L | X-ray | 1.90 | A/B | 227-449 | [»] | |
5WAV | X-ray | 2.60 | A/B | 228-448 | [»] | |
5XJE | X-ray | 2.40 | A/B | 227-449 | [»] | |
5XJF | X-ray | 2.50 | A/B | 227-449 | [»] | |
5XMH | X-ray | 2.80 | A/B | 239-446 | [»] | |
5Y56 | X-ray | 2.65 | A/B | 238-445 | [»] | |
5YC5 | X-ray | 2.71 | A/B | 226-448 | [»] | |
6APD | X-ray | 4.10 | J/K/N | 109-223 | [»] | |
6ARP | X-ray | 1.70 | B/D | 1-222 | [»] | |
6ARU | X-ray | 3.20 | C | 1-222 | [»] | |
6B70 | electron microscopy | 3.70 | C/E | 1-219 | [»] | |
6B7Z | electron microscopy | 6.50 | C/E | 1-219 | [»] | |
6BF7 | electron microscopy | 6.50 | C/E | 1-219 | [»] | |
6BF9 | electron microscopy | 7.20 | C/E | 1-219 | [»] | |
6BFT | X-ray | 2.55 | A/H | 1-227 | [»] | |
6BGT | X-ray | 2.70 | B | 1-222 | [»] | |
6BKB | X-ray | 2.80 | H | 2-222 | [»] | |
6BKC | X-ray | 2.60 | H | 4-222 | [»] | |
6BZ4 | X-ray | 2.40 | A/B | 239-446 | [»] | |
6DKJ | X-ray | 1.95 | A/H | 1-222 | [»] | |
6EAQ | X-ray | 2.22 | A/B | 227-446 | [»] | |
6FCZ | electron microscopy | 10.00 | H/K | 234-449 | [»] | |
6FGO | X-ray | 2.50 | A/B/C/D | 239-448 | [»] | |
6G1E | X-ray | 1.88 | B | 223-449 | [»] | |
6IFJ | X-ray | 2.40 | A/B | 218-449 | [»] | |
6IQG | X-ray | 3.00 | A/B | 238-447 | [»] | |
6IQH | X-ray | 3.00 | A/B | 238-447 | [»] | |
6KA7 | X-ray | 3.00 | C/D | 240-447 | [»] | |
6MB3 | electron microscopy | 3.37 | A/B/C/D/F/G/H/I/J | 1-223 | [»] | |
6MSY | X-ray | 2.00 | H | 1-221 | [»] | |
6MU3 | X-ray | 2.33 | H/M | 1-221 | [»] | |
6MUB | X-ray | 2.50 | H/M | 1-222 | [»] | |
6N2X | X-ray | 3.00 | H/M | 1-220 | [»] | |
6N32 | X-ray | 2.20 | H/K | 1-221 | [»] | |
6N35 | X-ray | 1.75 | H/M | 1-220 | [»] | |
6OGE | electron microscopy | 4.36 | C | 1-222 | [»] | |
6OKQ | X-ray | 3.20 | A/D/F | 1-226 | [»] | |
6P6D | X-ray | 2.31 | A/B | 223-449 | [»] | |
6UBI | X-ray | 1.90 | A/D | 4-226 | [»] | |
6UGW | X-ray | 2.00 | A | 211-449 | [»] | |
6UGX | X-ray | 2.10 | A/B | 211-449 | [»] | |
6UGY | X-ray | 2.10 | A | 211-449 | [»] | |
6UOE | X-ray | 1.80 | H | 1-223 | [»] | |
6V8Z | electron microscopy | 2.90 | C/I/O | 1-220 | [»] | |
6YSC | X-ray | 2.05 | A/B | 223-449 | [»] | |
6YT7 | X-ray | 1.55 | A | 223-449 | [»] | |
6YTB | X-ray | 1.65 | A/B | 223-449 | [»] | |
SMRi | P0DOX5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
PTM databases
CarbonylDBi | P0DOX5 |
iPTMneti | P0DOX5 |
Proteomic databases
EPDi | P0DOX5 |
jPOSTi | P0DOX5 |
MassIVEi | P0DOX5 |
PeptideAtlasi | P0DOX5 |
PRIDEi | P0DOX5 |
Miscellaneous databases
Pharosi | P0DOX5, Tdark |
Family and domain databases
Gene3Di | 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07654, C1-set, 3 hits PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00407, IGc1, 3 hits SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 4 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 4 hits PS00290, IG_MHC, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IGG1_HUMAN | |
Accessioni | P0DOX5Primary (citable) accession number: P0DOX5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2017 |
Last sequence update: | July 18, 2018 | |
Last modified: | February 10, 2021 | |
This is version 33 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references