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Protein

Immunoglobulin gamma-1 heavy chain

Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).3 Publications

Caution

This sequence is an example of a full-length immunoglobulin gamma-1 heavy chain.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin gamma-1 heavy chainCurated
Alternative name(s):
Immunoglobulin gamma-1 heavy chain NIE1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004392871 – 449Immunoglobulin gamma-1 heavy chainAdd BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi22 ↔ 961 Publication
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 2021 Publication
Disulfide bondi222Interchain (with light chain)1 Publication
Disulfide bondi228Interchain (with heavy chain)1 Publication
Disulfide bondi231Interchain (with heavy chain)1 Publication
Disulfide bondi263 ↔ 3231 Publication
Glycosylationi299N-linked (GlcNAc...) (complex) asparagine1 Publication1
Disulfide bondi369 ↔ 4271 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PeptideAtlasiP0DOX5
PRIDEiP0DOX5

PTM databases

CarbonylDBiP0DOX5
iPTMnetiP0DOX5

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Structurei

Secondary structure

1449
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiP0DOX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 96Ig-like 1PROSITE-ProRule annotationAdd BLAST96
Domaini125 – 218Ig-like 2PROSITE-ProRule annotationAdd BLAST94
Domaini240 – 339Ig-like 3PROSITE-ProRule annotationAdd BLAST100
Domaini348 – 444Ig-like 4PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 119Variable (V) domain, involved in antigen recognitionCuratedAdd BLAST119
Regioni120 – 449Constant (C) domainCuratedAdd BLAST330

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Immunoglobulin V region, Repeat

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07654 C1-set, 3 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00407 IGc1, 3 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits
PS00290 IG_MHC, 2 hits

Sequencei

Sequence statusi: Complete.

P0DOX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
QVQLVQSGGG VVQPGRSLRL SCAASGFTFS RYTIHWVRQA PGKGLEWVAV
60 70 80 90 100
MSYNGNNKHY ADSVNGRFTI SRNDSKNTLY LNMNSLRPED TAVYYCARIR
110 120 130 140 150
DTAMFFAHWG QGTLVTVSSA STKGPSVFPL APSSKSTSGG TAALGCLVKD
160 170 180 190 200
YFPEPVTVSW NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY
210 220 230 240 250
ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK
260 270 280 290 300
DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
310 320 330 340 350
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV
360 370 380 390 400
YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL
410 420 430 440
DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
Length:449
Mass (Da):49,329
Last modified:July 18, 2018 - v2
Checksum:iA7943E4D7C559ACE
GO

Similar proteinsi

Entry informationi

Entry nameiIGG1_HUMAN
AccessioniPrimary (citable) accession number: P0DOX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: July 18, 2018
Last modified: September 12, 2018
This is version 14 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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