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UniProtKB - P0DOX5 (IGG1_HUMAN)

Entry version 20 (08 May 2019)
Sequence version 2 (18 Jul 2018)
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Protein

Immunoglobulin gamma-1 heavy chain

Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).3 Publications

Caution

This sequence is an example of a full-length immunoglobulin gamma-1 heavy chain.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Immunity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunoglobulin gamma-1 heavy chainCurated
Alternative name(s):
Immunoglobulin gamma-1 heavy chain NIE1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Immunoglobulin, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004392871 – 449Immunoglobulin gamma-1 heavy chainAdd BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1Pyrrolidone carboxylic acid1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi22 ↔ 961 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 2021 Publication
Disulfide bondi222Interchain (with light chain)1 Publication
Disulfide bondi228Interchain (with heavy chain)1 Publication
Disulfide bondi231Interchain (with heavy chain)1 Publication
Disulfide bondi263 ↔ 3231 Publication
Glycosylationi299N-linked (GlcNAc...) (complex) asparagine1 Publication1
Disulfide bondi369 ↔ 4271 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		P0DOX5

PRoteomics IDEntifications database

More...PRIDEi		P0DOX5

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P0DOX5

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P0DOX5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1449
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5O4EX-ray2.15A227-449[»]
C227-448[»]
5VJ6electron microscopy11.50H3-224[»]
5VU0X-ray2.26A/B230-446[»]
5VZXX-ray2.50E/H1-227[»]
5VZYX-ray2.32H1-227[»]
5W5LX-ray1.90A/B227-449[»]
5WAVX-ray2.60A/B228-448[»]
5XJEX-ray2.40A/B227-449[»]
5XJFX-ray2.50A/B227-449[»]
5XMHX-ray2.80A/B239-446[»]
5Y56X-ray2.65A/B238-445[»]
5YC5X-ray2.71A/B226-448[»]
6APDX-ray4.10J/K/N109-223[»]
6ARPX-ray1.70B/D1-222[»]
6ARUX-ray3.20C1-222[»]
6B70electron microscopy3.70C/E1-219[»]
6B7Zelectron microscopy6.50C/E1-219[»]
6BF7electron microscopy6.50C/E1-219[»]
6BF9electron microscopy7.20C/E1-219[»]
6BFTX-ray2.55A/H1-227[»]
6BGTX-ray2.70B1-222[»]
6BKBX-ray2.80H2-222[»]
6BKCX-ray2.60H4-222[»]
6BZ4X-ray2.40A/B239-446[»]
6EAQX-ray2.22A/B227-446[»]
6FCZelectron microscopy10.00H/K234-449[»]
6FGOX-ray2.50A/B/C/D239-448[»]
6IQGX-ray3.00A/B238-447[»]
6IQHX-ray3.00A/B238-447[»]
6MB3electron microscopy3.37A/B/C/D/F/G/H/I/J1-223[»]
6MSYX-ray2.00H1-221[»]
6MU3X-ray2.33H/M1-221[»]
6MUBX-ray2.50H/M1-222[»]
6N2XX-ray3.00H/M1-220[»]
6N32X-ray2.20H/K1-221[»]
6N35X-ray1.75H/M1-220[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0DOX5

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 96Ig-like 1PROSITE-ProRule annotationAdd BLAST96
Domaini125 – 218Ig-like 2PROSITE-ProRule annotationAdd BLAST94
Domaini240 – 339Ig-like 3PROSITE-ProRule annotationAdd BLAST100
Domaini348 – 444Ig-like 4PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 119Variable (V) domain, involved in antigen recognitionCuratedAdd BLAST119
Regioni120 – 449Constant (C) domainCuratedAdd BLAST330

Keywords - Domaini

Immunoglobulin domain, Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR013106 Ig_V-set

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07654 C1-set, 3 hits
PF07686 V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409 IG, 2 hits
SM00407 IGc1, 3 hits
SM00406 IGv, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726 SSF48726, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835 IG_LIKE, 4 hits
PS00290 IG_MHC, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0DOX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
QVQLVQSGGG VVQPGRSLRL SCAASGFTFS RYTIHWVRQA PGKGLEWVAV 
        60         70         80         90        100
MSYNGNNKHY ADSVNGRFTI SRNDSKNTLY LNMNSLRPED TAVYYCARIR 
       110        120        130        140        150
DTAMFFAHWG QGTLVTVSSA STKGPSVFPL APSSKSTSGG TAALGCLVKD 
       160        170        180        190        200
YFPEPVTVSW NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY 
       210        220        230        240        250
ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK 
       260        270        280        290        300
DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS 
       310        320        330        340        350
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV 
       360        370        380        390        400
YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL 
       410        420        430        440 
DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
Length:449
Mass (Da):49,329
Last modified:July 18, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7943E4D7C559ACE
GO

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5O4EX-ray2.15A227-449[»]
C227-448[»]
5VJ6electron microscopy11.50H3-224[»]
5VU0X-ray2.26A/B230-446[»]
5VZXX-ray2.50E/H1-227[»]
5VZYX-ray2.32H1-227[»]
5W5LX-ray1.90A/B227-449[»]
5WAVX-ray2.60A/B228-448[»]
5XJEX-ray2.40A/B227-449[»]
5XJFX-ray2.50A/B227-449[»]
5XMHX-ray2.80A/B239-446[»]
5Y56X-ray2.65A/B238-445[»]
5YC5X-ray2.71A/B226-448[»]
6APDX-ray4.10J/K/N109-223[»]
6ARPX-ray1.70B/D1-222[»]
6ARUX-ray3.20C1-222[»]
6B70electron microscopy3.70C/E1-219[»]
6B7Zelectron microscopy6.50C/E1-219[»]
6BF7electron microscopy6.50C/E1-219[»]
6BF9electron microscopy7.20C/E1-219[»]
6BFTX-ray2.55A/H1-227[»]
6BGTX-ray2.70B1-222[»]
6BKBX-ray2.80H2-222[»]
6BKCX-ray2.60H4-222[»]
6BZ4X-ray2.40A/B239-446[»]
6EAQX-ray2.22A/B227-446[»]
6FCZelectron microscopy10.00H/K234-449[»]
6FGOX-ray2.50A/B/C/D239-448[»]
6IQGX-ray3.00A/B238-447[»]
6IQHX-ray3.00A/B238-447[»]
6MB3electron microscopy3.37A/B/C/D/F/G/H/I/J1-223[»]
6MSYX-ray2.00H1-221[»]
6MU3X-ray2.33H/M1-221[»]
6MUBX-ray2.50H/M1-222[»]
6N2XX-ray3.00H/M1-220[»]
6N32X-ray2.20H/K1-221[»]
6N35X-ray1.75H/M1-220[»]
SMRiP0DOX5
ModBaseiSearch...
MobiDBiSearch...

PTM databases

CarbonylDBiP0DOX5
iPTMnetiP0DOX5

Proteomic databases

PeptideAtlasiP0DOX5
PRIDEiP0DOX5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07654 C1-set, 3 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00407 IGc1, 3 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits
PS00290 IG_MHC, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0DOX5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: July 18, 2018
Last modified: May 8, 2019
This is version 20 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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