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Protein

Immunoglobulin epsilon heavy chain

Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).3 Publications

Caution

This sequence is an example of a full-length immunoglobulin epsilon heavy chain.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin epsilon heavy chainCurated
Alternative name(s):
Immunoglobulin epsilon heavy chain ND1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004392851 – 547Immunoglobulin epsilon heavy chainAdd BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi22 ↔ 961 Publication
Disulfide bondi138Interchain (with a light chain)1 Publication
Disulfide bondi139 ↔ 2251 Publication
Glycosylationi145N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi153 ↔ 2071 Publication
Glycosylationi173N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi219N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi241Interchain (with a heavy chain)1 Publication
Disulfide bondi254 ↔ 3121 Publication
Glycosylationi265N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi328Interchain (with a heavy chain)1 Publication
Disulfide bondi358 ↔ 4181 Publication
Glycosylationi371N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi394N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi464 ↔ 5241 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PeptideAtlasiP0DOX4

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Structurei

3D structure databases

SMRiP0DOX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 120Ig-like 1PROSITE-ProRule annotationAdd BLAST120
Domaini130 – 223Ig-like 2PROSITE-ProRule annotationAdd BLAST94
Domaini232 – 329Ig-like 3PROSITE-ProRule annotationAdd BLAST98
Domaini333 – 437Ig-like 4PROSITE-ProRule annotationAdd BLAST105
Domaini443 – 542Ig-like 5PROSITE-ProRule annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 124Variable (V) domain, involved in antigen recognitionCuratedAdd BLAST124
Regioni125 – 547Constant (C) domainCuratedAdd BLAST423

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Immunoglobulin V region, Repeat

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07654 C1-set, 4 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00407 IGc1, 4 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 5 hits
PS00290 IG_MHC, 3 hits

Sequencei

Sequence statusi: Complete.

P0DOX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
QVQLVQSGAE VRKPGASVRV SCKASGYTFI DSYVGWIRQA PGHGLEWIHW
60 70 80 90 100
INPNSGGTNY APRFQGRVTM TRDASFSTAY MDLRSLRSDD SAVFYCAKSD
110 120 130 140 150
PFWSDYNFDY SSSEEGTEVT YTVSGAWTLP SVFPLTRCCK NIPSNATSVT
160 170 180 190 200
LGCLATGYFP EPVMVTWDTG SLNGTTLPAT TLTLSGHYAT ISLLTVSGAW
210 220 230 240 250
AKQMFTCRVA HTPSSTVDNK TFSVCSRDFT PPTVKILQSS CDGLGHFPPT
260 270 280 290 300
IQLCLVSGYT PGTINITWLE DGQVMDVDLS TASTESQGEL ASTESQLTLS
310 320 330 340 350
QKHWLSDRTY TCQVTYQGHT FQDSTKKCAD SNPRGVSAYL SRPSPFDLFI
360 370 380 390 400
RKSPTITCLV VDLAPSKGTV NLTWSRASGK PVNHSTRKEE KQRNGTLTVT
410 420 430 440 450
STLPVGTRDW IEGETYQCRV THPHLPRALM RSTTKTSGPR AAPEVYAFAT
460 470 480 490 500
PEWPGSRDKR TLACLIQNFM PEDISVQWLH NEVQLPDARH STTQPRKTKG
510 520 530 540
SGFFVFSRLE VTRAEWQEKD EFICRAVHEA ASPSQTVQRA VSVNPGK
Length:547
Mass (Da):60,323
Last modified:March 15, 2017 - v1
Checksum:i865E343B2D159BA6
GO

Similar proteinsi

Cross-referencesi

3D structure databases

SMRiP0DOX4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiP0DOX4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07654 C1-set, 4 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00407 IGc1, 4 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 5 hits
PS00290 IG_MHC, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIGE_HUMAN
AccessioniPrimary (citable) accession number: P0DOX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: March 15, 2017
Last modified: February 28, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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