Immunoglobulin alpha-2 heavy chain

Functionⁱ

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).4 Publications

Caution

This sequence is an example of a full-length immunoglobulin alpha-2 heavy chain.Curated

GO - Molecular functionⁱ

antigen binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Adaptive immunity, Immunity

Biological process

Adaptive immunity, Immunity

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Immunoglobulin alpha-2 heavy chainCurated Alternative name(s): Immunoglobulin alpha-2 heavy chain BUT1 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000439283	1 – 455	Immunoglobulin alpha-2 heavy chainAdd BLAST		455

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	22 ↔ 95	1 PublicationPROSITE-ProRule annotation
Disulfide bondⁱ	141 ↔ 200	1 PublicationPROSITE-ProRule annotation
Glycosylationⁱ	162	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	207	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	216	Interchain (with light chain)1 Publication
Disulfide bondⁱ	224	Interchain (with heavy chain)1 Publication
Disulfide bondⁱ	225 ↔ 282	1 Publication
Glycosylationⁱ	246	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	249 ↔ 306	1 PublicationPROSITE-ProRule annotation
Disulfide bondⁱ	284	Interchain (with heavy chain)1 Publication
Disulfide bondⁱ	294	Interchain (with heavy chain of another subunit)1 Publication
Glycosylationⁱ	320	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	352 ↔ 415	1 PublicationPROSITE-ProRule annotation
Glycosylationⁱ	442	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	454	Interchain (with J chain)1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P0DOX2
PRIDEⁱ	P0DOX2

PTM databases

iPTMnetⁱ	P0DOX2

iPTMnetⁱ

P0DOX2

Interactionⁱ

Subunit structureⁱ

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked (PubMed:20176268). Monomeric or polymeric (PubMed:2241915).2 Publications

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 95	Ig-like 1PROSITE-ProRule annotationAdd BLAST	95
Domainⁱ	121 – 213	Ig-like 2PROSITE-ProRule annotationAdd BLAST	93
Domainⁱ	227 – 322	Ig-like 3PROSITE-ProRule annotationAdd BLAST	96
Domainⁱ	330 – 432	Ig-like 4PROSITE-ProRule annotationAdd BLAST	103

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 115	Variable (V) domain, involved in antigen recognition1 PublicationAdd BLAST		115
Regionⁱ	116 – 455	Constant (C) domain1 PublicationAdd BLAST		340

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	215 – 227	Pro-richPROSITE-ProRule annotationAdd BLAST		13

Keywords - Domainⁱ

Immunoglobulin C region, Immunoglobulin domain, Immunoglobulin V region, Repeat

Family and domain databases

Gene3Dⁱ	2.60.40.10, 4 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR003599 Ig_sub IPR013106 Ig_V-set IPR013151 Immunoglobulin
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654 C1-set, 2 hits PF00047 ig, 1 hit PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 4 hits SM00407 IGc1, 3 hits SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 4 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 4 hits PS00290 IG_MHC, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

P0DOX2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
EVQLVETGGG LIQPGGSLRL SCAASGFTVS NHSMSWVRQA PGKALEWVSA 
        60         70         80         90        100
IYRGGTTYYA DSVKGRFTIS RDDSRNTVYL QMNSLRAEDT AVYYCARDLA 
       110        120        130        140        150
AARLFGKGTT VTVSSASPTS PKVFPLSLDS TPQDGNVVVA CLVQGFFPQE 
       160        170        180        190        200
PLSVTWSESG QNVTARNFPP SQDASGDLYT TSSQLTLPAT QCPDGKSVTC 
       210        220        230        240        250
HVKHYTNSSQ DVTVPCRVPP PPPCCHPRLS LHRPALEDLL LGSEANLTCT 
       260        270        280        290        300
LTGLRDASGA TFTWTPSSGK SAVEGPPERD LCGCYSVSSV LPGCAQPWNH 
       310        320        330        340        350
GETFTCTAAH PELKTPLTAN ITKSGNTFRP EVHLLPPPSE ELALNELVTL 
       360        370        380        390        400
TCLARGFSPK DVLVRWLQGS QELPREKYLT WASRQEPSQG TTTYAVTSIL 
       410        420        430        440        450
RVAAEDWKKG ETFSCMVGHE ALPLAFTQKT IDRLAGKPTH INVSVVMAEA 

DGTCY

Length:455

Mass (Da):48,934

Last modified:July 18, 2018 - v2

Checksum:ⁱFCAFE11CBF1C57AE

GO

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P0DOX2	cDNA FLJ41981 fis, clone SMINT2011888, highly similar to Protein Tro alpha1 H,myeloma		HUMAN		487
Immunoglobulin heavy constant alpha 2 (Fragment)		HUMAN		340
Uncharacterized protein DKFZp686M08189		HUMAN		483
Uncharacterized protein DKFZp686L19235		HUMAN		479

Protein	Similar proteins		Species	Score	Length
P0DOX2	Immunoglobulin heavy constant alpha 1	)	HUMAN		353
Putative secreted protein		DESRO		478
Uncharacterized protein		MOUSE		482
Uncharacterized protein		GORGO		131
BWK3		RAT		482
+59

Cross-referencesⁱ

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

PTM databases

iPTMnetⁱ	P0DOX2

iPTMnetⁱ

P0DOX2

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P0DOX2
PRIDEⁱ	P0DOX2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Family and domain databases

Gene3Dⁱ	2.60.40.10, 4 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR003599 Ig_sub IPR013106 Ig_V-set IPR013151 Immunoglobulin
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654 C1-set, 2 hits PF00047 ig, 1 hit PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 4 hits SM00407 IGc1, 3 hits SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 4 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 4 hits PS00290 IG_MHC, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IGA2_HUMAN
Accessionⁱ	P0DOX2Primary (citable) accession number: P0DOX2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 15, 2017
	Last sequence update:	July 18, 2018
	Last modified:	July 18, 2018
	This is version 8 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Direct protein sequencing

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0DOX2 (IGA2_HUMAN)

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma membrane

Extracellular region or secreted

Plasma Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Family and domain databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ