UniProtKB - P0DOX2 (IGA2_HUMAN)
Protein
Immunoglobulin alpha-2 heavy chain
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).4 Publications
Caution
This sequence is an example of a full-length immunoglobulin alpha-2 heavy chain.Curated
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
Keywordsi
Biological process | Adaptive immunity, Immunity |
Names & Taxonomyi
Protein namesi | Recommended name: Immunoglobulin alpha-2 heavy chainCuratedAlternative name(s): Immunoglobulin alpha-2 heavy chain BUT1 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- immunoglobulin complex Source: UniProtKB-KW
Keywords - Cellular componenti
Cell membrane, Immunoglobulin, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000439283 | 1 – 455 | Immunoglobulin alpha-2 heavy chainAdd BLAST | 455 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 22 ↔ 95 | 1 PublicationPROSITE-ProRule annotation | ||
Disulfide bondi | 141 ↔ 200 | 1 PublicationPROSITE-ProRule annotation | ||
Glycosylationi | 162 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 207 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 216 | Interchain (with light chain)1 Publication | ||
Disulfide bondi | 224 | Interchain (with heavy chain)1 Publication | ||
Disulfide bondi | 225 ↔ 282 | 1 Publication | ||
Glycosylationi | 246 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 249 ↔ 306 | 1 PublicationPROSITE-ProRule annotation | ||
Disulfide bondi | 284 | Interchain (with heavy chain)1 Publication | ||
Disulfide bondi | 294 | Interchain (with heavy chain of another subunit)1 Publication | ||
Glycosylationi | 320 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 352 ↔ 415 | 1 PublicationPROSITE-ProRule annotation | ||
Glycosylationi | 442 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 454 | Interchain (with J chain)1 Publication |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P0DOX2 |
MassIVEi | P0DOX2 |
PeptideAtlasi | P0DOX2 |
PRIDEi | P0DOX2 |
PTM databases
iPTMneti | P0DOX2 |
Interactioni
Subunit structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 95 | Ig-like 1PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 121 – 213 | Ig-like 2PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 227 – 322 | Ig-like 3PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 330 – 432 | Ig-like 4PROSITE-ProRule annotationAdd BLAST | 103 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 115 | Variable (V) domain, involved in antigen recognition1 PublicationAdd BLAST | 115 | |
Regioni | 116 – 455 | Constant (C) domain1 PublicationAdd BLAST | 340 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 215 – 227 | Pro-richPROSITE-ProRule annotationAdd BLAST | 13 |
Keywords - Domaini
Immunoglobulin domain, RepeatFamily and domain databases
Gene3Di | 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR003599, Ig_sub IPR013106, Ig_V-set IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF07654, C1-set, 2 hits PF00047, ig, 1 hit PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 4 hits SM00407, IGc1, 3 hits SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 4 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 4 hits PS00290, IG_MHC, 2 hits |
i Sequence
Sequence statusi: Complete.
P0DOX2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
EVQLVETGGG LIQPGGSLRL SCAASGFTVS NHSMSWVRQA PGKALEWVSA
60 70 80 90 100
IYRGGTTYYA DSVKGRFTIS RDDSRNTVYL QMNSLRAEDT AVYYCARDLA
110 120 130 140 150
AARLFGKGTT VTVSSASPTS PKVFPLSLDS TPQDGNVVVA CLVQGFFPQE
160 170 180 190 200
PLSVTWSESG QNVTARNFPP SQDASGDLYT TSSQLTLPAT QCPDGKSVTC
210 220 230 240 250
HVKHYTNSSQ DVTVPCRVPP PPPCCHPRLS LHRPALEDLL LGSEANLTCT
260 270 280 290 300
LTGLRDASGA TFTWTPSSGK SAVEGPPERD LCGCYSVSSV LPGCAQPWNH
310 320 330 340 350
GETFTCTAAH PELKTPLTAN ITKSGNTFRP EVHLLPPPSE ELALNELVTL
360 370 380 390 400
TCLARGFSPK DVLVRWLQGS QELPREKYLT WASRQEPSQG TTTYAVTSIL
410 420 430 440 450
RVAAEDWKKG ETFSCMVGHE ALPLAFTQKT IDRLAGKPTH INVSVVMAEA
DGTCY
Similar proteinsi
Cross-referencesi
3D structure databases
SMRi | P0DOX2 |
ModBasei | Search... |
PTM databases
iPTMneti | P0DOX2 |
Proteomic databases
jPOSTi | P0DOX2 |
MassIVEi | P0DOX2 |
PeptideAtlasi | P0DOX2 |
PRIDEi | P0DOX2 |
Miscellaneous databases
Pharosi | P0DOX2, Tdark |
Family and domain databases
Gene3Di | 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR003599, Ig_sub IPR013106, Ig_V-set IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF07654, C1-set, 2 hits PF00047, ig, 1 hit PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 4 hits SM00407, IGc1, 3 hits SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 4 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 4 hits PS00290, IG_MHC, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IGA2_HUMAN | |
Accessioni | P0DOX2Primary (citable) accession number: P0DOX2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2017 |
Last sequence update: | July 18, 2018 | |
Last modified: | August 12, 2020 | |
This is version 15 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |