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Protein

Acyl-CoA C20 Delta5-desaturase

Gene

AL10

Organism
Anemone leveillei (Windflower)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the desaturation of 20:2Delta(11,14) and 20:3Delta(11,14,17) to generate sciadonic acid (20:3Delta(5,11,14)) and juniperonic acid (20:4Delta(5,11,14,17)).1 Publication

Catalytic activityi

(11Z,14Z)-icosa-11,14-dienoyl-CoA + reduced acceptor + O2 = (5Z,11Z,14Z)-icosa-5,11,14-trienoyl-CoA + acceptor + 2 H2O.1 Publication
(11Z,14Z,17Z)-icosa-11,14,17-trienoyl-CoA + reduced acceptor + O2 = (5Z,11Z,14Z,17Z)-icosa-5,11,14,17-tetraenoyl-CoA + acceptor + 2 H2O.1 Publication

Cofactori

Fe2+By similarityNote: Expected to bind 2 Fe2+ ions per subunit.By similarity

Pathwayi: polyunsaturated fatty acid biosynthesis

This protein is involved in the pathway polyunsaturated fatty acid biosynthesis, which is part of Lipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway polyunsaturated fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90Iron 1By similarity1
Metal bindingi95Iron 1By similarity1
Metal bindingi127Iron 1By similarity1
Metal bindingi130Iron 2By similarity1
Metal bindingi131Iron 1By similarity1
Metal bindingi230Iron 2By similarity1
Metal bindingi259Iron 2By similarity1
Metal bindingi262Iron 1By similarity1
Metal bindingi263Iron 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00658

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA C20 Delta5-desaturase1 Publication (EC:1.14.19.371 Publication)
Alternative name(s):
Acyl-CoA 5-desaturase (non-methylene-interrupted)1 Publication
Acyl-CoA 5-desaturase AL10Curated
Gene namesi
Name:AL101 Publication
OrganismiAnemone leveillei (Windflower)
Taxonomic identifieri212809 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsRanunculalesRanunculaceaeRanunculoideaeAnemoneaeAnemone

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004384981 – 312Acyl-CoA C20 Delta5-desaturaseAdd BLAST312

Structurei

3D structure databases

SMRiP0DOW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi90 – 95Histidine box-1By similarity6
Motifi127 – 131Histidine box-2By similarity5
Motifi259 – 263Histidine box-3By similarity5

Domaini

The histidine box domains are involved in binding the catalytic metal ions.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd03505 Delta9-FADS-like, 1 hit
InterProiView protein in InterPro
IPR015876 Acyl-CoA_DS
IPR005804 FA_desaturase_dom
PANTHERiPTHR11351 PTHR11351, 1 hit
PfamiView protein in Pfam
PF00487 FA_desaturase, 1 hit
PRINTSiPR00075 FACDDSATRASE

Sequencei

Sequence statusi: Complete.

P0DOW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLTSMAMQE TTAAAEEDRL PCSEVPVKEK TKKITWVRKW NSTDVFHILF
60 70 80 90 100
IGGLHVLCLF APSTFSWKSF WVCFALYAIC GVFGTTLSFH RNLTHRSFKL
110 120 130 140 150
PKYLEYFFAY VGLHALQGDP VWWVSTHRYH HKYTDTYLDP HSPIEGFWFC
160 170 180 190 200
HIFWLFDSKY IIEKCGRYEN AGDLMKQSYY RFLERTFVYH VYLQAALLYL
210 220 230 240 250
FGGFPFIVWG MAVRTILGFH LSWLVNSVCH RWGNRPWNTG DLSTNNWFIA
260 270 280 290 300
MLTSGEGWHN NHHAFEYSAR HGIEWWQIDT TWYIIKLLEY LGLATDIKVP
310
SEIHKRKMSF KN
Length:312
Mass (Da):36,952
Last modified:November 30, 2016 - v1
Checksum:iDABA4F1E819AB117
GO

Similar proteinsi

Cross-referencesi

3D structure databases

SMRiP0DOW2
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00658

Family and domain databases

CDDicd03505 Delta9-FADS-like, 1 hit
InterProiView protein in InterPro
IPR015876 Acyl-CoA_DS
IPR005804 FA_desaturase_dom
PANTHERiPTHR11351 PTHR11351, 1 hit
PfamiView protein in Pfam
PF00487 FA_desaturase, 1 hit
PRINTSiPR00075 FACDDSATRASE
ProtoNetiSearch...

Entry informationi

Entry nameiAL10_ANELE
AccessioniPrimary (citable) accession number: P0DOW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2016
Last sequence update: November 30, 2016
Last modified: May 10, 2017
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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