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Protein

Interferon-activable protein 205-B

Gene

Mnda

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a transcriptional regulator in the myeloid lineage. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways.2 Publications

Caution

The family of genes to which Mnda belongs has undergone a rapid expansion in the mouse. As a consequence, mouse Mnda and human MNDA genes, although belonging to the same family, are not one to one orthologs.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-activable protein 205-B
Short name:
Ifi-205-B
Alternative name(s):
Interferon-inducible protein p205-B
Myeloid cell nuclear differentiation antigen
Protein D3
Gene namesi
Name:Mnda
Synonyms:Ifi205b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3041120 Mnda

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001537221 – 425Interferon-activable protein 205-BAdd BLAST425

Proteomic databases

PRIDEiP0DOV1

PTM databases

iPTMnetiP0DOV1
PhosphoSitePlusiP0DOV1

Expressioni

Tissue specificityi

Mononuclear phagocytes.1 Publication

Inductioni

By lipopolysaccharides (LPS).1 Publication

Interactioni

Subunit structurei

Interacts with TP53, RB1, CDK1, CDK2 and HOXB2.1 Publication

GO - Molecular functioni

Structurei

Secondary structure

1425
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0DOV1
SMRiP0DOV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 88PyrinPROSITE-ProRule annotationAdd BLAST88
Repeati129 – 13517
Repeati136 – 14227
Repeati143 – 14937
Repeati150 – 15647
Domaini213 – 413HIN-200PROSITE-ProRule annotationAdd BLAST201

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni129 – 1774 X 7 AA tandem repeats of T-S-T-A-Q-A-[GR]Add BLAST49

Sequence similaritiesi

Belongs to the HIN-200 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J5NP Eukaryota
ENOG410Y78B LUCA
GeneTreeiENSGT00390000013296
HOVERGENiHBG006122
PhylomeDBiP0DOV1
TreeFamiTF337385

Family and domain databases

InterProiView protein in InterPro
IPR004020 DAPIN
IPR004021 HIN200/IF120x
PfamiView protein in Pfam
PF02760 HIN, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS50834 HIN_200, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P0DOV1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVNEYKRIVL LRGLECINKH YFSLFKSLLA RDLNLERDNQ EQYTTIQIAN
60 70 80 90 100
MMEEKFPADS GLGKLIEFCE EVPALRKRAE ILKKERSEVT GETSLEKNGQ
110 120 130 140 150
EAGPATPTST TSHMLASERG ETSATQEETS TAQAGTSTAQ AGTSTAQAGT
160 170 180 190 200
STAQKRKSMR EEETGVKKSK AAKEPDQPPC CEEPTAMCQS PILHSSSSAS
210 220 230 240 250
SNILSAKNQK SQPQNQNIPR GAVLHSEPLT VMVLTATDPF EYESPEHEVK
260 270 280 290 300
NMFHATVATV SQYFHVKVFN IDLKEKFTKN NFITISNYFE SKGILEINET
310 320 330 340 350
SSVLEAAPKQ MIEVPNCITR NANASPKICD IQKGTSGTVF YGVFTLHKKK
360 370 380 390 400
VKTQNTSYEI KDGSGSIEVV GSGQWHNINC KEGDKLHLFC FHLKRERGQP
410 420
KLVCGDHSFV KVTKAGKKKE ASTVQ
Length:425
Mass (Da):46,977
Last modified:November 2, 2016 - v1
Checksum:i4CC601557C946E2B
GO
Isoform 2 (identifier: P0DOV1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-90: Missing.

Note: No experimental confirmation available.
Show »
Length:423
Mass (Da):46,777
Checksum:i81F3CAB420A431DA
GO

Sequence cautioni

The sequence BAE31364 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142G → R in BAE38635 (PubMed:16141072).Curated1
Sequence conflicti148A → E in BAE38635 (PubMed:16141072).Curated1
Sequence conflicti276K → E in BAE31415 (PubMed:16141072).Curated1
Sequence conflicti277F → S in BAE38635 (PubMed:16141072).Curated1
Sequence conflicti350K → N in BAE38635 (PubMed:16141072).Curated1
Sequence conflicti366S → R in AAB26880 (PubMed:7684766).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05858989 – 90Missing in isoform 2. 2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62227 mRNA Translation: AAB26880.1
AK152621 mRNA Translation: BAE31364.1 Different initiation.
AK080485 mRNA Translation: BAC37930.1
AK152683 mRNA Translation: BAE31415.1
AK152786 mRNA Translation: BAE31495.1
AK166217 mRNA Translation: BAE38635.1
BC132314 mRNA Translation: AAI32315.1
BC132316 mRNA Translation: AAI32317.1
BC145397 mRNA Translation: AAI45398.1
CCDSiCCDS15532.1 [P0DOV1-1]
RefSeqiNP_001028622.1, NM_001033450.4 [P0DOV1-1]
NP_001288674.1, NM_001301745.1 [P0DOV1-2]
UniGeneiMm.490248

Genome annotation databases

EnsembliENSMUST00000009340; ENSMUSP00000009340; ENSMUSG00000026536 [P0DOV1-1]
GeneIDi381308
KEGGimmu:381308

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIFI5B_MOUSE
AccessioniPrimary (citable) accession number: P0DOV1
Secondary accession number(s): B7ZNS3
, P15092, Q08619, Q3TM07, Q3U776, Q3U7F4, Q3U7K5, Q3UCH9, Q8C4X3, Q921V9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: November 2, 2016
Last modified: September 12, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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