UniProtKB - P0DOJ5 (LT_POVM3)
Large T antigen
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 293 – 407 | T-ag OBDPROSITE-ProRule annotationAdd BLAST | 115 | |
Zinc fingeri | 416 – 510 | T-ag D1-typePROSITE-ProRule annotationAdd BLAST | 95 | |
Nucleotide bindingi | 575 – 582 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA replication origin binding Source: InterPro
- hydrolase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- DNA replication Source: UniProtKB-KW
- modulation by virus of host G1/S transition checkpoint Source: UniProtKB-KW
- suppression by virus of host JAK1 activity Source: UniProtKB-KW
- suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | |
Organismi | Murine polyomavirus (strain A3) (MPyV) |
Taxonomic identifieri | 157703 [NCBI] |
Taxonomic lineagei | Viruses › Monodnaviria › Shotokuvirae › Cossaviricota › Papovaviricetes › Sepolyvirales › Polyomaviridae › Alphapolyomavirus › |
Virus hosti | Mus musculus (Mouse) [TaxID: 10090] |
Proteomesi |
|
Subcellular locationi
- Host nucleus By similarity
GO - Cellular componenti
- host cell nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host nucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000442782 | 1 – 782 | Large T antigenAdd BLAST | 782 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine; by hostBy similarity | 1 | |
Modified residuei | 278 | Phosphothreonine; by hostBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinInteractioni
Subunit structurei
Forms homohexamers in the presence of ATP.
Interacts with host HDAC1.
Interacts (via LXCXE domain) with host RB1; the interaction induces the aberrant dissociation of RB1-E2F1 complex thereby disrupting RB1's activity.
Interacts (via LXCXE domain) with host pRB-related proteins RBL1 and RBL2.
Interacts (via C-terminus) with host TOP1 and POLA1 allowing DNA replication.
Interacts with host preinitiation complex components TBP, TFIIA and TFIID to regulate transcription initiation.
By similarityStructurei
Secondary structure
3D structure databases
SMRi | P0DOJ5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 75 | JAdd BLAST | 64 | |
Domaini | 549 – 709 | SF3 helicasePROSITE-ProRule annotationAdd BLAST | 161 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 142 – 146 | LXCXE motifBy similarity | 5 | |
Motifi | 279 – 286 | Nuclear localization signalBy similarity | 8 |
Domaini
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 416 – 510 | T-ag D1-typePROSITE-ProRule annotationAdd BLAST | 95 |
Keywords - Domaini
Zinc-fingerFamily and domain databases
Gene3Di | 1.10.287.110, 1 hit |
InterProi | View protein in InterPro IPR001623, DnaJ_domain IPR014015, Helicase_SF3_DNA-vir IPR036869, J_dom_sf IPR010932, Lg_T_Ag_Polyomavir_C IPR027417, P-loop_NTPase IPR003133, T_Ag_DNA-bd IPR017910, Znf_lg_T-Ag_D1-typ |
Pfami | View protein in Pfam PF06431, Polyoma_lg_T_C, 1 hit PF02217, T_Ag_DNA_bind, 1 hit |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit |
SUPFAMi | SSF46565, SSF46565, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51206, SF3_HELICASE_1, 1 hit PS51287, T_AG_OBD, 1 hit PS51341, ZF_LTAG_D1, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDRVLSRADK ERLLELLKLP RQLWGDFGRM QQAYKQQSLL LHPDKGGSHA
60 70 80 90 100
LMQELNSLWG TFKTEVYNLR MNLGGTGFQG SPPRTAERGT EESGHSPLHD
110 120 130 140 150
DYWSFSYGSK YFTREWNDFF RKWDPSYQSP PKTAESSEQP DLFCYEEPLL
160 170 180 190 200
SPNPSSPTDT PAHTAGRRRN PCVAEPDDSI SPDPPRTPVS RKRPRPAGAT
210 220 230 240 250
GGGGGGVHAN GGSVFGHPTG GTSTPAHPPP YHSQGGSESM GGSDSSGFAE
260 270 280 290 300
GSFRSDPRCE SENESYSQSC SQSSFNATPP KKAREDPAPS DFPSSLTGYL
310 320 330 340 350
SHAIYSNKTF PAFLVYSTKE KCKQLYDTIG KFRPEFKCLV HYEEGGMLFF
360 370 380 390 400
LTMTKHRVSA VKNYCSKLCS VSFLMCKAVT KPMECYQVVT AAPFQLITEN
410 420 430 440 450
KPGLHQFEFT DEPEEQKAVD WIMVADFALE NNLDDPLLIM GYYLDFAKEV
460 470 480 490 500
PSCIKCSKEE TRLQIHWKNH RKHAENADLF LNCKAQKTIC QQAADGVLAS
510 520 530 540 550
RRLKLVECTR SQLLKERLQQ SLLRLKELGS SDALLYLAGV AWYQCLLEDF
560 570 580 590 600
PQTLFKMLKL LTENVPKRRN ILFRGPVNSG KTGLAAALIS LLGGKSLNIN
610 620 630 640 650
CPADKLAFEL GVAQDQFVVC FEDVKGQIAL NKQLQPGMGV ANLDNLRDYL
660 670 680 690 700
DGSVKVNLEK KHSNKRSQLF PPCVCTMNEY LLPQTVWARF HMVLDFTCKP
710 720 730 740 750
HLAQSLEKCE FLQRERIIQS GDTLALLLIW NFTSDVFDPD IQGLVKEVRD
760 770 780
QFASECSYSL FCDILCNVQE GDDPLKDICE YS
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02289 Genomic DNA Translation: AAA46872.1 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02289 Genomic DNA Translation: AAA46872.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1FAF | NMR | - | A | 1-79 | [»] | |
SMRi | P0DOJ5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Family and domain databases
Gene3Di | 1.10.287.110, 1 hit |
InterProi | View protein in InterPro IPR001623, DnaJ_domain IPR014015, Helicase_SF3_DNA-vir IPR036869, J_dom_sf IPR010932, Lg_T_Ag_Polyomavir_C IPR027417, P-loop_NTPase IPR003133, T_Ag_DNA-bd IPR017910, Znf_lg_T-Ag_D1-typ |
Pfami | View protein in Pfam PF06431, Polyoma_lg_T_C, 1 hit PF02217, T_Ag_DNA_bind, 1 hit |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit |
SUPFAMi | SSF46565, SSF46565, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51206, SF3_HELICASE_1, 1 hit PS51287, T_AG_OBD, 1 hit PS51341, ZF_LTAG_D1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LT_POVM3 | |
Accessioni | P0DOJ5Primary (citable) accession number: P0DOJ5 Secondary accession number(s): P03074 Q89471 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2017 |
Last sequence update: | December 20, 2017 | |
Last modified: | December 2, 2020 | |
This is version 14 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references