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UniProtKB - P0DOH3 (GGAG_FLV)
Protein
Glyco-Gag protein
Gene
N/A
Organism
Feline leukemia virus
Status
Functioni
Plays a role in viral particle release. Presumably acts by facilitating the fission of the virion bud at the cell surface.
By similarityGO - Molecular functioni
- nucleic acid binding Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- virion assembly Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: Glyco-Gag proteinAlternative name(s): Gross cell surface antigen glycosylated Pr80 gag Short name: gPr80 Gag Short name: gag-gPr80 |
Organismi | Feline leukemia virus |
Taxonomic identifieri | 11768 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Pararnavirae › Artverviricota › Revtraviricetes › Ortervirales › Retroviridae › Orthoretrovirinae › Gammaretrovirus |
Virus hosti | Felidae (cat family) [TaxID: 9681] |
Subcellular locationi
- Host cell membrane Sequence analysisBy similarity; Single-pass membrane protein By similarity
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 51 | CytoplasmicCuratedAdd BLAST | 51 | |
Transmembranei | 52 – 72 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 73 – 580 | ExtracellularCuratedAdd BLAST | 508 |
Keywords - Cellular componenti
Host cell membrane, Host membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000441137 | 1 – 580 | Glyco-Gag proteinAdd BLAST | 580 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 134 | N-linked (GlcNAc...) asparagine; by hostPROSITE-ProRule annotation | 1 | |
Glycosylationi | 572 | N-linked (GlcNAc...) asparagine; by hostPROSITE-ProRule annotation | 1 |
Post-translational modificationi
Glycosylated by host.By similarity
Cleaved by host near the middle of the molecule, releasing the c-terminal half containing capsid and nucleoprotein domains op GAG.By similarity
Keywords - PTMi
GlycoproteinFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 171 – 282 | DisorderedSequence analysisAdd BLAST | 112 | |
Regioni | 491 – 514 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 560 – 580 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 171 – 192 | Pro residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 202 – 248 | Pro residuesSequence analysisAdd BLAST | 47 |
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 1.10.150.180, 1 hit 1.10.375.10, 1 hit |
InterProi | View protein in InterPro IPR000840, G_retro_matrix IPR036946, G_retro_matrix_sf IPR003036, Gag_P30 IPR008919, Retrov_capsid_N IPR010999, Retrovr_matrix IPR001878, Znf_CCHC IPR036875, Znf_CCHC_sf |
Pfami | View protein in Pfam PF01140, Gag_MA, 1 hit PF02093, Gag_p30, 1 hit PF00098, zf-CCHC, 1 hit |
SMARTi | View protein in SMART SM00343, ZnF_C2HC, 1 hit |
SUPFAMi | SSF47836, SSF47836, 1 hit SSF47943, SSF47943, 1 hit SSF57756, SSF57756, 1 hit |
PROSITEi | View protein in PROSITE PS50158, ZF_CCHC, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basketIsoform Glyco-Gag protein (identifier: P0DOH3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGASSGTAI GAHLFGVSPE YRVLIGDGGA GPSKSLSEVS FSVWYRSRAA
60 70 80 90 100
RLVILCLVAS FLVPCLTFLI AEAVMGQTVT TPLSLTLDHW SEVRARAHNQ
110 120 130 140 150
GVEVRKKKWI TLCEAEWVMM NVGWPREGTF SLDNISQVEK KIFAPGPHGH
160 170 180 190 200
PDQVPYITTW RSLATDPPSW VRPFLPPPKP PTPLPQPLSP QPSAPLTSSL
210 220 230 240 250
YPVVPKPDPP KPPVLPPDPS SPLIDLLTEE PPPYPGGHGP PPSGPRTPAA
260 270 280 290 300
SPIASRLRER RENPAEESQA LPLREGPNNR PQYWPFSASD LYNWKSHNPP
310 320 330 340 350
FSQDPVALTN LIESILVTHQ PTWDDCQQLL QALLTGEERQ RVLLEARKQV
360 370 380 390 400
PGEDGRPTQL PNVIDETFPL TRPNWDFATP AGREHLRLYR QLLLAGLRGA
410 420 430 440 450
ARRPTNLAQV KQVVQGKEET PAAFLERLKE AYRMYTPYDP EDPGQAASVI
460 470 480 490 500
LSFIYQSSPD IRNKLQRLEG LQGFTLSDLL KEAEKIYNKR ETPEEREERL
510 520 530 540 550
WQRQEERDKK RHKEMTKVLA TVVAQNRDKD REENKLGDQR KIPLGKDQCA
560 570 580
YCKEKGHWVR DCPKRPRKKP ANSTLLNLED
Isoform Gag polyprotein (identifier: P10262-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P10262.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K01803 Genomic RNA Translation: AAA43055.1 |
Keywords - Coding sequence diversityi
Alternative initiationSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K01803 Genomic RNA Translation: AAA43055.1 |
3D structure databases
SMRi | P0DOH3 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 1.10.150.180, 1 hit 1.10.375.10, 1 hit |
InterProi | View protein in InterPro IPR000840, G_retro_matrix IPR036946, G_retro_matrix_sf IPR003036, Gag_P30 IPR008919, Retrov_capsid_N IPR010999, Retrovr_matrix IPR001878, Znf_CCHC IPR036875, Znf_CCHC_sf |
Pfami | View protein in Pfam PF01140, Gag_MA, 1 hit PF02093, Gag_p30, 1 hit PF00098, zf-CCHC, 1 hit |
SMARTi | View protein in SMART SM00343, ZnF_C2HC, 1 hit |
SUPFAMi | SSF47836, SSF47836, 1 hit SSF47943, SSF47943, 1 hit SSF57756, SSF57756, 1 hit |
PROSITEi | View protein in PROSITE PS50158, ZF_CCHC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GGAG_FLV | |
Accessioni | P0DOH3Primary (citable) accession number: P0DOH3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2017 |
Last sequence update: | August 30, 2017 | |
Last modified: | June 2, 2021 | |
This is version 11 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |