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Protein

Choriogonadotropin subunit beta 7

Gene

CGB7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.Curated

Miscellaneous

Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates.1 Publication

GO - Molecular functioni

  • hormone activity Source: ProtInc

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Choriogonadotropin subunit beta 7
Gene namesi
Name:CGB7Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16451 CGB7
MIMi608826 gene
neXtProtiNX_P0DN87

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi94027
OpenTargetsiENSG00000196337

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000043615221 – 165Choriogonadotropin subunit beta 7Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 77By similarity
Glycosylationi33N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi43 ↔ 92By similarity
Disulfide bondi46 ↔ 130By similarity
Glycosylationi50N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi54 ↔ 108By similarity
Disulfide bondi58 ↔ 110By similarity
Disulfide bondi113 ↔ 120By similarity
Glycosylationi141O-linked (GalNAc...) serineBy similarity1
Glycosylationi147O-linked (GalNAc...) serineBy similarity1
Glycosylationi152O-linked (GalNAc...) serineBy similarity1
Glycosylationi158O-linked (GalNAc...) serineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP0DN87
PaxDbiP0DN87
PeptideAtlasiP0DN87
PRIDEiP0DN87

Expressioni

Tissue specificityi

High expression in the placenta throughout pregnancy.1 Publication

Developmental stagei

Expressed in the placenta throughout pregnancy.1 Publication

Gene expression databases

ExpressionAtlasiP0DN87 baseline and differential

Organism-specific databases

HPAiHPA038925
HPA038934

Interactioni

Subunit structurei

Heterodimer of a common alpha chain identical in LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones and confers receptor and biological specificity.Curated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366493

Structurei

3D structure databases

ProteinModelPortaliP0DN87
SMRiP0DN87
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000010115
KOiK10045
OMAiTSGAWAS
PhylomeDBiP0DN87

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DN87-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEMFQGLLLL LLLSMGGTWA SREMLRPRCR PINATLAVEK EGCPVCITVN
60 70 80 90 100
TTICAGYCPT MTRVLQGVLP ALPQVVCNYR DVRFESIRLP GCPRGVNPVV
110 120 130 140 150
SYAVALSCQC ALCRRSTTDC GGPKDHPLTC DDPRFQASSS SKAPPPSLPS
160
PSRLPGPSDT PILPQ
Length:165
Mass (Da):17,757
Last modified:May 11, 2016 - v1
Checksum:iB9C34C7B8EDD469F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125108 mRNA No translation available.
AC008687 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52439.1
CCDSiCCDS33071.1
RefSeqiNP_149133.1, NM_033142.1
XP_016882991.1, XM_017027502.1
UniGeneiHs.681647
Hs.745468

Genome annotation databases

EnsembliENST00000377280; ENSP00000366493; ENSG00000196337
ENST00000596965; ENSP00000469076; ENSG00000196337
ENST00000597853; ENSP00000470813; ENSG00000196337
GeneIDi94027
KEGGihsa:94027

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125108 mRNA No translation available.
AC008687 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52439.1
CCDSiCCDS33071.1
RefSeqiNP_149133.1, NM_033142.1
XP_016882991.1, XM_017027502.1
UniGeneiHs.681647
Hs.745468

3D structure databases

ProteinModelPortaliP0DN87
SMRiP0DN87
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000366493

Proteomic databases

MaxQBiP0DN87
PaxDbiP0DN87
PeptideAtlasiP0DN87
PRIDEiP0DN87

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377280; ENSP00000366493; ENSG00000196337
ENST00000596965; ENSP00000469076; ENSG00000196337
ENST00000597853; ENSP00000470813; ENSG00000196337
GeneIDi94027
KEGGihsa:94027

Organism-specific databases

CTDi94027
DisGeNETi94027
GeneCardsiCGB7
HGNCiHGNC:16451 CGB7
HPAiHPA038925
HPA038934
MIMi608826 gene
neXtProtiNX_P0DN87
OpenTargetsiENSG00000196337
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000010115
KOiK10045
OMAiTSGAWAS
PhylomeDBiP0DN87

Miscellaneous databases

PROiPR:P0DN87
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiP0DN87 baseline and differential

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCGB7_HUMAN
AccessioniPrimary (citable) accession number: P0DN87
Secondary accession number(s): A1A5E0
, B9ZVP5, P01233, Q13991, Q14000, Q3KPI3, Q3SY41, Q8WTT5, Q8WXL1, Q8WXL2, Q8WXL3, Q8WXL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 11, 2016
Last sequence update: May 11, 2016
Last modified: November 7, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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