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Protein

Choriogonadotropin subunit beta 3

Gene

CGB3

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.Curated

Miscellaneous

Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • hormone activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-209822 Glycoprotein hormones
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Choriogonadotropin subunit beta 3
Alternative name(s):
Choriogonadotropin subunit beta
Short name:
CG-beta
Chorionic gonadotropin chain beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CGB3
Synonyms:CGB
AND
Name:CGB5
AND
Name:CGB8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1886 CGB3
HGNC:16452 CGB5
HGNC:16453 CGB8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
118860 gene
608825 gene
608827 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P0DN86

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a protein as a pharmaceutical drug. It indicates the name of the drug, the name of the firm that commercializes it and explains in a few words in which context the drug is used. In some cases, drugs that are under development are also described.<p><a href='/help/pharmaceutical_use' target='_top'>More...</a></p>Pharmaceutical usei

Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting from caloric restriction, that it causes a more attractive or 'normal' distribution of fat, or that it decreases the hunger and discomfort associated with calorie-restricted diets.

Organism-specific databases

DisGeNET

More...
DisGeNETi
1082
93659
94115

Open Targets

More...
OpenTargetsi
ENSG00000189052
ENSG00000213030

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CGB5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 202 PublicationsAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001167621 – 165Choriogonadotropin subunit beta 3Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi29 ↔ 772 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_00004233N-linked (GlcNAc...) asparagineCombined sources1
Disulfide bondi43 ↔ 922 Publications
Disulfide bondi46 ↔ 1302 Publications
GlycosylationiCAR_00004350N-linked (GlcNAc...) asparagineCombined sources1
Disulfide bondi54 ↔ 1082 Publications
Disulfide bondi58 ↔ 1102 Publications
Disulfide bondi113 ↔ 1202 Publications
Glycosylationi141O-linked (GalNAc...) serine1 Publication1
Glycosylationi147O-linked (GalNAc...) serine1 Publication1
Glycosylationi152O-linked (GalNAc...) serine1 Publication1
Glycosylationi158O-linked (GalNAc...) serine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P0DN86

PeptideAtlas

More...
PeptideAtlasi
P0DN86

PRoteomics IDEntifications database

More...
PRIDEi
P0DN86

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
88
91

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0DN86

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P0DN86

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P01233

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High expression in the placenta throughout pregnancy.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed continuously during the whole pregnancy with a peak during the first trimester.1 Publication

Gene expression databases

CleanEx database of gene expression profiles

More...
CleanExi
HS_CGB
HS_CGB5
HS_CGB7

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P0DN86 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01233 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000042
CAB010884
HPA038925
HPA038934

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a common alpha chain identical in LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones.Curated1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P0DN86, 4 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HCNX-ray2.60B21-165[»]
1HRPX-ray3.00B21-165[»]
1QFWX-ray3.50B21-165[»]
1XULmodel-B21-165[»]

Database of protein disorder

More...
DisProti
DP00013

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P0DN86

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P0DN86

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163162

KEGG Orthology (KO)

More...
KOi
K10045

Identification of Orthologs from Complete Genome Data

More...
OMAi
TTTICAG

Database of Orthologous Groups

More...
OrthoDBi
543832at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0DN86

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00069 GHB_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS

The PANTHER Classification System

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PANTHERi
PTHR11515 PTHR11515, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00007 Cys_knot, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00068 GHB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57501 SSF57501, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P0DN86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEMFQGLLLL LLLSMGGTWA SKEPLRPRCR PINATLAVEK EGCPVCITVN
60 70 80 90 100
TTICAGYCPT MTRVLQGVLP ALPQVVCNYR DVRFESIRLP GCPRGVNPVV
110 120 130 140 150
SYAVALSCQC ALCRRSTTDC GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS
160
PSRLPGPSDT PILPQ
Length:165
Mass (Da):17,739
Last modified:May 11, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5598FB9E51A05748
GO
Isoform 2 (identifier: P0DN86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MEMF → MGRPGLGAAVSDPGEAVSLS

Show »
Length:181
Mass (Da):19,053
Checksum:i853B736271867359
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA25068 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA25069 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti123P → T in AAL69709 (PubMed:11861891).Curated1
Isoform 2 (identifier: P0DN86-2)
Sequence conflicti7G → R in CAA25069 (PubMed:6690982).Curated1
Sequence conflicti9A → V in CAA25069 (PubMed:6690982).Curated1
Sequence conflicti12D → G in CAA25069 (PubMed:6690982).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0145854F → L1 PublicationCorresponds to variants dbSNP:rs767100833 and dbSNP:rs371475564EnsemblEnsembl.1
Natural variantiVAR_01523118T → A1 PublicationCorresponds to variant dbSNP:rs201240617Ensembl.1
Natural variantiVAR_01458622K → R1 PublicationCorresponds to variants dbSNP:rs201575305 and dbSNP:rs199720009EnsemblEnsembl.1
Natural variantiVAR_01523224P → M Requires 2 nucleotide substitutions. 2 Publications1
Natural variantiVAR_01523328R → W1 PublicationCorresponds to variant dbSNP:rs1261895475Ensembl.1
Natural variantiVAR_01523430R → H1 PublicationCorresponds to variant dbSNP:rs201373221Ensembl.1
Natural variantiVAR_01458735T → I1 PublicationCorresponds to variants dbSNP:rs201780746 and dbSNP:rs199824672EnsemblEnsembl.1
Natural variantiVAR_003188137D → A4 PublicationsCorresponds to variants dbSNP:rs200199557 and dbSNP:rs199614255EnsemblEnsembl.1
Natural variantiVAR_015235147S → C1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0383961 – 4MEMF → MGRPGLGAAVSDPGEAVSLS in isoform 2. Curated4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J00117 mRNA Translation: AAA96690.1
X00265 Genomic DNA Translation: CAA25068.1 Different initiation.
X00266 Genomic DNA Translation: CAA25069.1 Different initiation.
K03189, K03187, K03188 Genomic DNA Translation: AAA53288.1
K03183, K00092, K03182 Genomic DNA Translation: AAA53287.1
BT006890 mRNA Translation: AAP35536.1
AK291552 mRNA Translation: BAF84241.1
AC008687 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52434.1
CH471177 Genomic DNA Translation: EAW52437.1
CH471177 Genomic DNA Translation: EAW52438.1
BC006290 mRNA Translation: AAH06290.1
BC022796 mRNA Translation: AAH22796.1
BC030994 mRNA Translation: AAH30994.1
BC041054 mRNA Translation: AAH41054.1
BC051378 mRNA Translation: AAH51378.1
BC069526 mRNA Translation: AAH69526.1
BC103969 mRNA Translation: AAI03970.1
BC103970 mRNA Translation: AAI03971.1
BC103971 mRNA Translation: AAI03972.1
BC106059 mRNA Translation: AAI06060.1
BC106723 mRNA Translation: AAI06724.1
BC106724 mRNA Translation: AAI06725.1
BC128603 mRNA Translation: AAI28604.1
M13503 Genomic DNA Translation: AAA52009.1
M13504 Genomic DNA Translation: AAA52005.1
M13505 Genomic DNA Translation: AAA52008.1
AF397576 Genomic DNA Translation: AAL69704.1
AF397577 Genomic DNA Translation: AAL69705.1
AF397578 Genomic DNA Translation: AAL69706.1
AF397579 Genomic DNA Translation: AAL69707.1
AF397580 Genomic DNA Translation: AAL69708.1
AF397581 Genomic DNA Translation: AAL69709.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12749.1 [P0DN86-1]

Protein sequence database of the Protein Information Resource

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PIRi
A93230 KTHUB
I37231

NCBI Reference Sequences

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RefSeqi
NP_000728.1, NM_000737.3 [P0DN86-1]
NP_149032.1, NM_033043.1 [P0DN86-1]
NP_149439.1, NM_033183.2 [P0DN86-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.172944
Hs.446683
Hs.659014
Hs.681647
Hs.743279
Hs.745468

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000301408; ENSP00000301408; ENSG00000189052 [P0DN86-1]
ENST00000357383; ENSP00000349954; ENSG00000104827 [P0DN86-1]
ENST00000448456; ENSP00000403649; ENSG00000213030 [P0DN86-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1082
93659
94115

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1082
hsa:93659
hsa:94115

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Chorionic gonadotropin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00117 mRNA Translation: AAA96690.1
X00265 Genomic DNA Translation: CAA25068.1 Different initiation.
X00266 Genomic DNA Translation: CAA25069.1 Different initiation.
K03189, K03187, K03188 Genomic DNA Translation: AAA53288.1
K03183, K00092, K03182 Genomic DNA Translation: AAA53287.1
BT006890 mRNA Translation: AAP35536.1
AK291552 mRNA Translation: BAF84241.1
AC008687 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52434.1
CH471177 Genomic DNA Translation: EAW52437.1
CH471177 Genomic DNA Translation: EAW52438.1
BC006290 mRNA Translation: AAH06290.1
BC022796 mRNA Translation: AAH22796.1
BC030994 mRNA Translation: AAH30994.1
BC041054 mRNA Translation: AAH41054.1
BC051378 mRNA Translation: AAH51378.1
BC069526 mRNA Translation: AAH69526.1
BC103969 mRNA Translation: AAI03970.1
BC103970 mRNA Translation: AAI03971.1
BC103971 mRNA Translation: AAI03972.1
BC106059 mRNA Translation: AAI06060.1
BC106723 mRNA Translation: AAI06724.1
BC106724 mRNA Translation: AAI06725.1
BC128603 mRNA Translation: AAI28604.1
M13503 Genomic DNA Translation: AAA52009.1
M13504 Genomic DNA Translation: AAA52005.1
M13505 Genomic DNA Translation: AAA52008.1
AF397576 Genomic DNA Translation: AAL69704.1
AF397577 Genomic DNA Translation: AAL69705.1
AF397578 Genomic DNA Translation: AAL69706.1
AF397579 Genomic DNA Translation: AAL69707.1
AF397580 Genomic DNA Translation: AAL69708.1
AF397581 Genomic DNA Translation: AAL69709.1
CCDSiCCDS12749.1 [P0DN86-1]
PIRiA93230 KTHUB
I37231
RefSeqiNP_000728.1, NM_000737.3 [P0DN86-1]
NP_149032.1, NM_033043.1 [P0DN86-1]
NP_149439.1, NM_033183.2 [P0DN86-1]
UniGeneiHs.172944
Hs.446683
Hs.659014
Hs.681647
Hs.743279
Hs.745468

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HCNX-ray2.60B21-165[»]
1HRPX-ray3.00B21-165[»]
1QFWX-ray3.50B21-165[»]
1XULmodel-B21-165[»]
DisProtiDP00013
ProteinModelPortaliP0DN86
SMRiP0DN86
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0DN86, 4 interactors

PTM databases

GlyConnecti88
91
iPTMnetiP0DN86
PhosphoSitePlusiP0DN86
UniCarbKBiP01233

Polymorphism and mutation databases

BioMutaiCGB5

Proteomic databases

MaxQBiP0DN86
PeptideAtlasiP0DN86
PRIDEiP0DN86

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301408; ENSP00000301408; ENSG00000189052 [P0DN86-1]
ENST00000357383; ENSP00000349954; ENSG00000104827 [P0DN86-1]
ENST00000448456; ENSP00000403649; ENSG00000213030 [P0DN86-1]
GeneIDi1082
93659
94115
KEGGihsa:1082
hsa:93659
hsa:94115

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1082
93659
94115
DisGeNETi1082
93659
94115

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CGB3
CGB5
CGB8
HGNCiHGNC:1886 CGB3
HGNC:16452 CGB5
HGNC:16453 CGB8
HPAiCAB000042
CAB010884
HPA038925
HPA038934
MIMi118860 gene
608825 gene
608827 gene
neXtProtiNX_P0DN86
OpenTargetsiENSG00000189052
ENSG00000213030

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000163162
KOiK10045
OMAiTTTICAG
OrthoDBi543832at2759
PhylomeDBiP0DN86

Enzyme and pathway databases

ReactomeiR-HSA-209822 Glycoprotein hormones
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CGB8 human

Protein Ontology

More...
PROi
PR:P0DN86

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

CleanExiHS_CGB
HS_CGB5
HS_CGB7
ExpressionAtlasiP0DN86 baseline and differential
GenevisibleiP01233 HS

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCGB3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0DN86
Secondary accession number(s): A1A5E0
, B9ZVP5, P01233, Q13991, Q14000, Q3KPI3, Q3SY41, Q8WTT5, Q8WXL1, Q8WXL2, Q8WXL3, Q8WXL4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 11, 2016
Last sequence update: May 11, 2016
Last modified: January 16, 2019
This is version 25 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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