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Entry version 16 (07 Apr 2021)
Sequence version 2 (03 Jul 2019)
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Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF



Homo sapiens (Human)
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulate SERCA pump activity. Enhances sarcoplasmic reticulum Ca2+ uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN).

By similarity

<p>The <a href="">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data


Protein family/group databases

Transport Classification Database

1.A.50.4.1, the phospholamban (ca(2+)-channel and ca(2+)-atpase regulator) (plb) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORFCurated
Short name:
SERCA regulator DWORFCurated
Alternative name(s):
Dwarf open reading frame1 Publication
Short name:
DWORF1 Publication
Small transmembrane regulator of ion transport 1Imported
<p>This subsection of the <a href="">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Synonyms:DWORF1 Publication
<p>This subsection of the <a href="">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="">Names and taxonomy</a> section is present for entries that are part of a <a href="">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

HGNC:52297, STRIT1

Online Mendelian Inheritance in Man (OMIM)

616891, gene

neXtProt; the human protein knowledge platform


<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi


Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets


Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

P0DN84, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database


<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004358021 – 35Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORFAdd BLAST35

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei


Interacts with ATP2A1/SERCA1.

By similarity

<p>This subsection of the '<a href="">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="">IntAct database</a>. It is updated at every <a href="">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
ANK1 - isoform Mu17 [P16157-17]3EBI-12200293,EBI-941819
ANKS6 [Q68DC2]3EBI-12200293,EBI-7054139
AQP12B - isoform 2 [A6NM10-2]3EBI-12200293,EBI-17265552
AQP6 [Q13520]3EBI-12200293,EBI-13059134
ARL13B [Q3SXY8]3EBI-12200293,EBI-11343438
BIK [Q13323]3EBI-12200293,EBI-700794
BSCL2 [J3KQ12]5EBI-12200293,EBI-11532900
BTN2A1 - isoform 4 [Q7KYR7-4]3EBI-12200293,EBI-17841208
CD53 [P19397]3EBI-12200293,EBI-6657396
CD69 [Q07108]3EBI-12200293,EBI-2836595
CD79A [P11912]3EBI-12200293,EBI-7797864
CMTM2 [Q8TAZ6]3EBI-12200293,EBI-2339374
EDA2R [Q9HAV5]3EBI-12200293,EBI-526033
F11R [Q9Y624]3EBI-12200293,EBI-742600
FFAR2 [O15552]3EBI-12200293,EBI-2833872
FXYD3 - isoform 3 [Q14802-3]3EBI-12200293,EBI-12175685
GOLM1 [Q8NBJ4]3EBI-12200293,EBI-712073
GPR42 [O15529]3EBI-12200293,EBI-18076404
GPR61 [Q9BZJ8]3EBI-12200293,EBI-12808020
HSD17B11 [Q8NBQ5]3EBI-12200293,EBI-1052304
HSD17B13 [Q7Z5P4]3EBI-12200293,EBI-18053395
IFNGR2 [P38484]3EBI-12200293,EBI-3905457
ISLR2 [Q6UXK2]3EBI-12200293,EBI-1266923
JPH1 [Q9HDC5]3EBI-12200293,EBI-465137
KCNJ6 [P48051]3EBI-12200293,EBI-12017638
KCNK5 [O95279]3EBI-12200293,EBI-3934936
MFF - isoform 5 [Q9GZY8-5]3EBI-12200293,EBI-11956541
MOG - isoform 13 [Q16653-13]3EBI-12200293,EBI-24226707
MSMO1 [Q15800]3EBI-12200293,EBI-949102
MTIF3 [Q9H2K0]3EBI-12200293,EBI-3923617
PDZK1IP1 [Q13113]3EBI-12200293,EBI-716063
PI16 [Q6UXB8]3EBI-12200293,EBI-12810028
SCN3B [Q9NY72]3EBI-12200293,EBI-17247926
SLC14A1 - isoform 2 [Q13336-2]3EBI-12200293,EBI-19141793
SLC34A2 - isoform 2 [O95436-2]3EBI-12200293,EBI-12811757
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-12200293,EBI-17295964
SLC38A1 [Q9H2H9]3EBI-12200293,EBI-9978441
SPNS3 - isoform 2 [Q6ZMD2-2]3EBI-12200293,EBI-17848320
STX1A [Q16623]3EBI-12200293,EBI-712466
STX2 - isoform 1 [P32856-2]3EBI-12200293,EBI-11956649
TM4SF18 [Q96CE8]3EBI-12200293,EBI-13351685
TMEM101 [Q96IK0]3EBI-12200293,EBI-3922699
TMEM237 - isoform 2 [Q96Q45-2]3EBI-12200293,EBI-10982110
TMEM51 [Q9NW97]3EBI-12200293,EBI-726044
TSPAN15 [O95858]3EBI-12200293,EBI-7361096

Protein-protein interaction databases

Protein interaction database and analysis system

P0DN84, 45 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree


Family and domain databases

Conserved Domains Database

cd20247, DWORF, 1 hit

Integrated resource of protein families, domains and functional sites

View protein in InterPro
IPR044529, DWORF

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="">length</a> and <a href="">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="">Sequence</a> section indicates if the <a href="">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0DN84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30 
Mass (Da):3,836
Last modified:July 3, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD31615174585708

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database


GenBank nucleotide sequence database


DNA Data Bank of Japan; a nucleotide sequence database

Links Updated
AC104831 Genomic DNA No translation available.

The Consensus CDS (CCDS) project


Genome annotation databases

Ensembl eukaryotic genome annotation project

ENST00000489090; ENSP00000489859; ENSG00000240045

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
Links Updated
AC104831 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models


SWISS-MODEL Interactive Workspace

Submit a new modelling project...

Protein-protein interaction databases

IntActiP0DN84, 45 interactors

Protein family/group databases

TCDBi1.A.50.4.1, the phospholamban (ca(2+)-channel and ca(2+)-atpase regulator) (plb) family

Genetic variation databases


Genome annotation databases

EnsembliENST00000489090; ENSP00000489859; ENSG00000240045

Organism-specific databases

GeneCards: human genes, protein and diseases

MIMi616891, gene

GenAtlas: human gene database


Phylogenomic databases


Enzyme and pathway databases


Miscellaneous databases

PharosiP0DN84, Tdark

Protein Ontology


The Stanford Online Universal Resource for Clones and ESTs


Family and domain databases

CDDicd20247, DWORF, 1 hit
InterProiView protein in InterPro
IPR044529, DWORF

MobiDB: a database of protein disorder and mobility annotations


<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDWORF_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0DN84
Secondary accession number(s): A0A1B0GTW0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 16, 2016
Last sequence update: July 3, 2019
Last modified: April 7, 2021
This is version 16 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome


  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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