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Protein

Splicing factor U2AF 35 kDa subunit-like protein

Gene

U2AF1L5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.By similarity

Caution

There is a duplication of the U2AF1 gene on chromosome 21. U2AF1 (AC Q01081) and U2AF1L5 (AC P0DN76) encode identical proteins.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 40C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri149 – 176C3H1-type 2PROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • pre-mRNA 3'-splice site binding Source: GO_Central
  • RS domain binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor U2AF 35 kDa subunit-like proteinCurated
Alternative name(s):
U2 small nuclear RNA auxiliary factor 1-like protein 5Imported
Gene namesi
Name:U2AF1L5Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:51830 U2AF1L5
neXtProtiNX_P0DN76

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi102724594
7307
OpenTargetsiENSG00000160201

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00004354022 – 240Splicing factor U2AF 35 kDa subunit-like proteinAdd BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei39N6-methyllysineCombined sources1
Modified residuei61PhosphoserineCombined sources1
Modified residuei145PhosphoserineCombined sources1
Modified residuei165Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP0DN76
PeptideAtlasiP0DN76
PRIDEiP0DN76

PTM databases

iPTMnetiP0DN76
PhosphoSitePlusiP0DN76

Expressioni

Gene expression databases

ExpressionAtlasiP0DN76 baseline and differential

Organism-specific databases

HPAiHPA044833
HPA052083

Interactioni

Subunit structurei

Interacts (via RS domain) with PHF5A (via N-terminus). Identified in the spliceosome C complex. Heterodimer with U2AF2. Interacts with ZRANB2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
U2AF2P26368-24EBI-14082807,EBI-11097439

GO - Molecular functioni

Protein-protein interaction databases

IntActiP0DN76, 15 interactors

Structurei

3D structure databases

ProteinModelPortaliP0DN76
SMRiP0DN76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 147RRMPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 40C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri149 – 176C3H1-type 2PROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

KOiK12836
PhylomeDBiP0DN76

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
IPR009145 U2AF_small
IPR000571 Znf_CCCH
PANTHERiPTHR12620 PTHR12620, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF00642 zf-CCCH, 2 hits
PRINTSiPR01848 U2AUXFACTOR
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00361 RRM_1, 1 hit
SM00356 ZnF_C3H1, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50103 ZF_C3H1, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P0DN76-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEYLASIFG TEKDKVNCSF YFKIGACRHG DRCSRLHNKP TFSQTIALLN
60 70 80 90 100
IYRNPQNSSQ SADGLRCAVS DVEMQEHYDE FFEEVFTEME EKYGEVEEMN
110 120 130 140 150
VCDNLGDHLV GNVYVKFRRE EDAEKAVIDL NNRWFNGQPI HAELSPVTDF
160 170 180 190 200
REACCRQYEM GECTRGGFCN FMHLKPISRE LRRELYGRRR KKHRSRSRSR
210 220 230 240
ERRSRSRDRG RGGGGGGGGG GGGRERDRRR SRDRERSGRF
Length:240
Mass (Da):27,872
Last modified:February 17, 2016 - v1
Checksum:i3DA130DCE0B953F6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GW87A0A1B0GW87_HUMAN
Splicing factor U2AF 35 kDa subunit...
U2AF1L5 U2AF1
45Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP236240 Genomic DNA No translation available.
CCDSiCCDS82649.1
RefSeqiNP_001307575.1, NM_001320646.1
NP_006749.1, NM_006758.2
UniGeneiHs.365116

Genome annotation databases

EnsembliENST00000610664; ENSP00000485022; ENSG00000275895
GeneIDi102724594
7307
KEGGihsa:102724594

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP236240 Genomic DNA No translation available.
CCDSiCCDS82649.1
RefSeqiNP_001307575.1, NM_001320646.1
NP_006749.1, NM_006758.2
UniGeneiHs.365116

3D structure databases

ProteinModelPortaliP0DN76
SMRiP0DN76
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0DN76, 15 interactors

PTM databases

iPTMnetiP0DN76
PhosphoSitePlusiP0DN76

Proteomic databases

EPDiP0DN76
PeptideAtlasiP0DN76
PRIDEiP0DN76

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000610664; ENSP00000485022; ENSG00000275895
GeneIDi102724594
7307
KEGGihsa:102724594

Organism-specific databases

CTDi102724594
7307
DisGeNETi102724594
7307
GeneCardsiU2AF1L5
HGNCiHGNC:51830 U2AF1L5
HPAiHPA044833
HPA052083
neXtProtiNX_P0DN76
OpenTargetsiENSG00000160201
GenAtlasiSearch...

Phylogenomic databases

KOiK12836
PhylomeDBiP0DN76

Miscellaneous databases

PROiPR:P0DN76

Gene expression databases

ExpressionAtlasiP0DN76 baseline and differential

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
IPR009145 U2AF_small
IPR000571 Znf_CCCH
PANTHERiPTHR12620 PTHR12620, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF00642 zf-CCCH, 2 hits
PRINTSiPR01848 U2AUXFACTOR
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00361 RRM_1, 1 hit
SM00356 ZnF_C3H1, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50103 ZF_C3H1, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiU2AF5_HUMAN
AccessioniPrimary (citable) accession number: P0DN76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 17, 2016
Last sequence update: February 17, 2016
Last modified: November 7, 2018
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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