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Protein

Peptidyl-prolyl cis-trans isomerase A-like 4F

Gene

PPIAL4F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Miscellaneous

It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.Curated

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase A-like 4FCurated (EC:5.2.1.8)
Short name:
PPIase A-like 4F
Gene namesi
Name:PPIAL4FImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000279782.1
HGNCiHGNC:33999 PPIAL4F
neXtProtiNX_P0DN26

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004339261 – 164Peptidyl-prolyl cis-trans isomerase A-like 4FAdd BLAST164

Proteomic databases

EPDiP0DN26
PeptideAtlasiP0DN26
PRIDEiP0DN26

PTM databases

iPTMnetiP0DN26
PhosphoSitePlusiP0DN26

Expressioni

Gene expression databases

BgeeiENSG00000279782 Expressed in 13 organ(s), highest expression level in nucleus accumbens

Organism-specific databases

HPAiHPA058345

Structurei

3D structure databases

ProteinModelPortaliP0DN26
SMRiP0DN26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 163PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST157

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00760000119119
KOiK12738

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P0DN26-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNSVVFFEI TRDGKPLGRI SIKLFADKIP KTAENFRALS TGEKGFRYKG
60 70 80 90 100
SCFHRIIPGF MCQGGDFTRP NGTGDKSIYG EKFDDENLIR KHTGSGILSM
110 120 130 140 150
ANAGPNTNGS QFFICAAKTE WLDGKHVAFG KVKERVNIVE AMEHFGYRNS
160
KTSKKITIAD CGQF
Length:164
Mass (Da):18,197
Last modified:October 14, 2015 - v1
Checksum:iFD7DF57F1A6FDAA9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0H2UH34A0A0H2UH34_HUMAN
Peptidyl-prolyl cis-trans isomerase
PPIAL4F
164Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC253578 Genomic DNA No translation available.
CCDSiCCDS76202.1
RefSeqiNP_001137504.2, NM_001144032.2
NP_001157734.2, NM_001164262.2

Genome annotation databases

EnsembliENST00000581138; ENSP00000485638; ENSG00000279782
GeneIDi728945
730262
KEGGihsa:728945
hsa:730262

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC253578 Genomic DNA No translation available.
CCDSiCCDS76202.1
RefSeqiNP_001137504.2, NM_001144032.2
NP_001157734.2, NM_001164262.2

3D structure databases

ProteinModelPortaliP0DN26
SMRiP0DN26
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP0DN26
PhosphoSitePlusiP0DN26

Proteomic databases

EPDiP0DN26
PeptideAtlasiP0DN26
PRIDEiP0DN26

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000581138; ENSP00000485638; ENSG00000279782
GeneIDi728945
730262
KEGGihsa:728945
hsa:730262

Organism-specific databases

CTDi728945
730262
EuPathDBiHostDB:ENSG00000279782.1
GeneCardsiPPIAL4F
HGNCiHGNC:33999 PPIAL4F
HPAiHPA058345
neXtProtiNX_P0DN26
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119119
KOiK12738

Miscellaneous databases

PROiPR:P0DN26

Gene expression databases

BgeeiENSG00000279782 Expressed in 13 organ(s), highest expression level in nucleus accumbens

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAL4F_HUMAN
AccessioniPrimary (citable) accession number: P0DN26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: October 14, 2015
Last modified: September 12, 2018
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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