UniProtKB - P0DMS9 (TMIG3_HUMAN)
Protein
Transmembrane domain-containing protein TMIGD3
Gene
TMIGD3
Organism
Homo sapiens (Human)
Status
Functioni
Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186).1 Publication
GO - Biological processi
- activation of adenylate cyclase activity Source: ProtInc
- inflammatory response Source: ProtInc
- negative regulation of cell migration Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
- regulation of heart contraction Source: ProtInc
- response to wounding Source: ProtInc
- signal transduction Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | P0DMS9 |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane domain-containing protein TMIGD3Curated |
Gene namesi | Name:TMIGD3Imported ORF Names:UNQ1931/PRO4406 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000121933.17 |
HGNCi | HGNC:51375, TMIGD3 |
neXtProti | NX_P0DMS9 |
Subcellular locationi
Other locations
- Membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
Other locations
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 55 – 75 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 213 – 233 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 57413 |
OpenTargetsi | ENSG00000121933 |
PharmGKBi | PA24589 |
Miscellaneous databases
Pharosi | P0DMS9, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3712907 |
Polymorphism and mutation databases
BioMutai | TMIGD3 |
DMDMi | 380876892 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000416044 | 1 – 266 | Transmembrane domain-containing protein TMIGD3Add BLAST | 266 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 192 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | P0DMS9 |
PaxDbi | P0DMS9 |
PeptideAtlasi | P0DMS9 |
PRIDEi | P0DMS9 |
ProteomicsDBi | 66913 |
PTM databases
GlyGeni | P0DMS9, 1 site |
iPTMneti | P0DMS9 |
PhosphoSitePlusi | P0DMS9 |
Expressioni
Tissue specificityi
Expressed in the lung and bone. Expressed at lower levels in osteosarcoma tissues (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000121933, Expressed in substantia nigra and 140 other tissues |
ExpressionAtlasi | P0DMS9, baseline and differential |
Genevisiblei | P0DMS9, HS |
Organism-specific databases
HPAi | ENSG00000121933, Group enriched (blood, brain, testis) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000358730 |
Chemistry databases
BindingDBi | P0DMS9 |
Miscellaneous databases
RNActi | P0DMS9, protein |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00930000151073 |
HOGENOMi | CLU_091386_0_0_1 |
OMAi | AMAHTEQ |
OrthoDBi | 890536at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
SUPFAMi | SSF48726, SSF48726, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 3 (identifier: P0DMS9-1) [UniParc]FASTAAdd to basket
Also known as: TMIGD3 i31 Publication, A3AR i31 Publication
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEGSPAGPIE QKEARWESSW EEQPDWTLGC LSPESQFRIP GLPGCILSFQ
60 70 80 90 100
LKVCFLPVMW LFILLSLALI SDAMVMDEKV KRSFVLDTAS AICNYNAHYK
110 120 130 140 150
NHPKYWCRGY FRDYCNIIAF SPNSTNHVAL RDTGNQLIVT MSCLTKEDTG
160 170 180 190 200
WYWCGIQRDF ARDDMDFTEL IVTDDKGTLA NDFWSGKDLS GNKTRSCKAP
210 220 230 240 250
KVVRKADRSR TSILIICILI TGLGIISVIS HLTKRRRSQR NRRVGNTLKP
260
FSRVLTPKEM APTEQM
Isoform 1 (identifier: P0DMS9-2) [UniParc]FASTAAdd to basket
Also known as: TMIGD3 i11 Publication, A3AR i11 Publication
The sequence of this isoform differs from the canonical sequence as follows:
1-36: MEGSPAGPIE...TLGCLSPESQ → MPNNSTALSL...RYLRVKLTVR
Note: The first exon of TMIGD3 isoform 1 (i1) is shared with the first exon of ADORA3 isoform 2 (A3AR i2, commonly known as A3AR), resulting in a fusion protein.1 Publication
Show »Isoform 2 (identifier: P0DMS8-1) [UniParc]FASTAAdd to basket
Also known as: A3AR i21 Publication, A3AR1 Publication
The sequence of this isoform can be found in the external entry P0DMS8.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5QNY8 | Q5QNY8_HUMAN | Transmembrane domain-containing pro... | TMIGD3 | 172 | Annotation score: | ||
A0A0J9YY46 | A0A0J9YY46_HUMAN | Transmembrane domain-containing pro... | TMIGD3 | 107 | Annotation score: |
Sequence cautioni
The sequence AAH41707 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH64411 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence EAW56500 differs from that shown. Reason: Erroneous gene model prediction.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057521 | 1 – 36 | MEGSP…SPESQ → MPNNSTALSLANVTYITMEI FIGLCAIVGNVLVICVVKLN PSLQTTTFYFIVSLALADIA VGVLVMPLAIVVSLGITIHF YSCLFMTCLLLIFTHASIMS LLAIAVDRYLRVKLTVR in isoform 1. Add BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358644 mRNA Translation: AAQ89007.1 AL390195 Genomic DNA No translation available. AL391063 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56500.1 Sequence problems. BC041707 mRNA Translation: AAH41707.1 Different initiation. BC064411 mRNA Translation: AAH64411.1 Different initiation. |
CCDSi | CCDS41369.1 [P0DMS9-1] CCDS838.1 [P0DMS9-2] |
RefSeqi | NP_001075445.1, NM_001081976.2 [P0DMS9-1] NP_001289609.1, NM_001302680.1 NP_065734.5, NM_020683.6 [P0DMS9-2] |
Genome annotation databases
Ensembli | ENST00000369716; ENSP00000358730; ENSG00000121933 [P0DMS9-2] ENST00000369717; ENSP00000358731; ENSG00000121933 [P0DMS9-1] |
GeneIDi | 57413 |
KEGGi | hsa:57413 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358644 mRNA Translation: AAQ89007.1 AL390195 Genomic DNA No translation available. AL391063 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56500.1 Sequence problems. BC041707 mRNA Translation: AAH41707.1 Different initiation. BC064411 mRNA Translation: AAH64411.1 Different initiation. |
CCDSi | CCDS41369.1 [P0DMS9-1] CCDS838.1 [P0DMS9-2] |
RefSeqi | NP_001075445.1, NM_001081976.2 [P0DMS9-1] NP_001289609.1, NM_001302680.1 NP_065734.5, NM_020683.6 [P0DMS9-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000358730 |
Chemistry databases
BindingDBi | P0DMS9 |
ChEMBLi | CHEMBL3712907 |
PTM databases
GlyGeni | P0DMS9, 1 site |
iPTMneti | P0DMS9 |
PhosphoSitePlusi | P0DMS9 |
Polymorphism and mutation databases
BioMutai | TMIGD3 |
DMDMi | 380876892 |
Proteomic databases
MassIVEi | P0DMS9 |
PaxDbi | P0DMS9 |
PeptideAtlasi | P0DMS9 |
PRIDEi | P0DMS9 |
ProteomicsDBi | 66913 |
Protocols and materials databases
Antibodypediai | 20120, 88 antibodies |
DNASUi | 140 |
Genome annotation databases
Ensembli | ENST00000369716; ENSP00000358730; ENSG00000121933 [P0DMS9-2] ENST00000369717; ENSP00000358731; ENSG00000121933 [P0DMS9-1] |
GeneIDi | 57413 |
KEGGi | hsa:57413 |
Organism-specific databases
CTDi | 57413 |
DisGeNETi | 57413 |
EuPathDBi | HostDB:ENSG00000121933.17 |
GeneCardsi | TMIGD3 |
HGNCi | HGNC:51375, TMIGD3 |
HPAi | ENSG00000121933, Group enriched (blood, brain, testis) |
neXtProti | NX_P0DMS9 |
OpenTargetsi | ENSG00000121933 |
PharmGKBi | PA24589 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00930000151073 |
HOGENOMi | CLU_091386_0_0_1 |
OMAi | AMAHTEQ |
OrthoDBi | 890536at2759 |
Enzyme and pathway databases
PathwayCommonsi | P0DMS9 |
Miscellaneous databases
BioGRID-ORCSi | 57413, 0 hits in 14 CRISPR screens |
ChiTaRSi | TMIGD3, human |
GenomeRNAii | 57413 |
Pharosi | P0DMS9, Tchem |
PROi | PR:P0DMS9 |
RNActi | P0DMS9, protein |
Gene expression databases
Bgeei | ENSG00000121933, Expressed in substantia nigra and 140 other tissues |
ExpressionAtlasi | P0DMS9, baseline and differential |
Genevisiblei | P0DMS9, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
SUPFAMi | SSF48726, SSF48726, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TMIG3_HUMAN | |
Accessioni | P0DMS9Primary (citable) accession number: P0DMS9 Secondary accession number(s): A2A3P4 Q9BYZ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 2015 |
Last sequence update: | April 1, 2015 | |
Last modified: | December 2, 2020 | |
This is version 40 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM