UniProtKB - P0DMS8 (AA3R_HUMAN)
Protein
Adenosine receptor A3
Gene
ADORA3
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase (PubMed:8234299).1 Publication
GO - Molecular functioni
- G protein-coupled adenosine receptor activity Source: InterPro
GO - Biological processi
- activation of adenylate cyclase activity Source: ProtInc
- G protein-coupled receptor signaling pathway Source: Reactome
- inflammatory response Source: ProtInc
- negative regulation of cell migration Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
- regulation of heart contraction Source: ProtInc
- response to wounding Source: ProtInc
- signal transduction Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P0DMS8 |
Reactomei | R-HSA-417973, Adenosine P1 receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | P0DMS8 |
Names & Taxonomyi
Protein namesi | Recommended name: Adenosine receptor A3 |
Gene namesi | Name:ADORA3Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:268, ADORA3 |
MIMi | 600445, gene |
neXtProti | NX_P0DMS8 |
VEuPathDBi | HostDB:ENSG00000282608.1 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 14 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 15 – 37 | Helical; Name=1By similarityAdd BLAST | 23 | |
Topological domaini | 38 – 48 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 49 – 72 | Helical; Name=2By similarityAdd BLAST | 24 | |
Topological domaini | 73 – 84 | ExtracellularBy similarityAdd BLAST | 12 | |
Transmembranei | 85 – 106 | Helical; Name=3By similarityAdd BLAST | 22 | |
Topological domaini | 107 – 126 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 127 – 148 | Helical; Name=4By similarityAdd BLAST | 22 | |
Topological domaini | 149 – 177 | ExtracellularBy similarityAdd BLAST | 29 | |
Transmembranei | 178 – 198 | Helical; Name=5By similarityAdd BLAST | 21 | |
Topological domaini | 199 – 231 | CytoplasmicBy similarityAdd BLAST | 33 | |
Transmembranei | 232 – 255 | Helical; Name=6By similarityAdd BLAST | 24 | |
Topological domaini | 256 – 261 | ExtracellularBy similarity | 6 | |
Transmembranei | 262 – 284 | Helical; Name=7By similarityAdd BLAST | 23 | |
Topological domaini | 285 – 318 | CytoplasmicBy similarityAdd BLAST | 34 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 140 |
OpenTargetsi | ENSG00000282608 |
Miscellaneous databases
Pharosi | P0DMS8, Tchem |
Chemistry databases
ChEMBLi | CHEMBL256 |
DrugBanki | DB00640, Adenosine DB01223, Aminophylline DB00201, Caffeine DB00824, Enprofylline DB12010, Fostamatinib DB05511, Piclidenoson |
DrugCentrali | P0DMS8 |
GuidetoPHARMACOLOGYi | 21 |
Genetic variation databases
BioMutai | ADORA3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069010 | 1 – 318 | Adenosine receptor A3Add BLAST | 318 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 3 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 12 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 83 ↔ 166 | PROSITE-ProRule annotation | ||
Lipidationi | 303 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
MassIVEi | P0DMS8 |
PeptideAtlasi | P0DMS8 |
PRIDEi | P0DMS8 |
PTM databases
GlyGeni | P0DMS8, 3 sites |
iPTMneti | P0DMS8 |
PhosphoSitePlusi | P0DMS8 |
Expressioni
Tissue specificityi
Expressed in the lung and bone. Expressed at lower levels in osteosarcoma tissues (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000282608, Expressed in substantia nigra and 150 other tissues |
ExpressionAtlasi | P0DMS8, baseline and differential |
Genevisiblei | P0DMS8, HS |
Organism-specific databases
HPAi | ENSG00000282608, Group enriched (blood, brain) |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00990000203639 |
HOGENOMi | CLU_009579_11_5_1 |
OMAi | INCITYF |
OrthoDBi | 550297at2759 |
PhylomeDBi | P0DMS8 |
Family and domain databases
InterProi | View protein in InterPro IPR000466, Adeno_A3_rcpt IPR001634, Adenosn_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00555, ADENOSINEA3R PR00424, ADENOSINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 2 (identifier: P0DMS8-1) [UniParc]FASTAAdd to basket
Also known as: A3AR i21 Publication, A3AR1 Publication
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPNNSTALSL ANVTYITMEI FIGLCAIVGN VLVICVVKLN PSLQTTTFYF
60 70 80 90 100
IVSLALADIA VGVLVMPLAI VVSLGITIHF YSCLFMTCLL LIFTHASIMS
110 120 130 140 150
LLAIAVDRYL RVKLTVRYKR VTTHRRIWLA LGLCWLVSFL VGLTPMFGWN
160 170 180 190 200
MKLTSEYHRN VTFLSCQFVS VMRMDYMVYF SFLTWIFIPL VVMCAIYLDI
210 220 230 240 250
FYIIRNKLSL NLSNSKETGA FYGREFKTAK SLFLVLFLFA LSWLPLSIIN
260 270 280 290 300
CIIYFNGEVP QLVLYMGILL SHANSMMNPI VYAYKIKKFK ETYLLILKAC
310
VVCHPSDSLD TSIEKNSE
Isoform 1 (identifier: P0DMS9-2) [UniParc]FASTAAdd to basket
Also known as: TMIGD3 i11 Publication, A3AR i11 Publication
The sequence of this isoform can be found in the external entry P0DMS9.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0J9YWR0 | A0A0J9YWR0_HUMAN | Adenosine receptor A3 | ADORA3 | 123 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | A → T in AAA16365 (PubMed:8399349).Curated | 1 | |
Sequence conflicti | 175 | D → V in AAG35155 (PubMed:11214319).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035755 | 105 | A → T in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs746154553Ensembl. | 1 | |
Natural variantiVAR_049366 | 248 | I → L1 PublicationCorresponds to variant dbSNP:rs35511654Ensembl. | 1 | |
Natural variantiVAR_049367 | 266 | M → K. Corresponds to variant dbSNP:rs2800889Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L20463 mRNA Translation: AAA16365.1 L22607 mRNA Translation: AAA35949.1 X76981 mRNA Translation: CAA54288.1 L77730, L77729 Genomic DNA Translation: AAB02790.1 AY136749 mRNA Translation: AAN01275.1 AL390195 Genomic DNA No translation available. BC029831 mRNA Translation: AAH29831.1 AY011231 Genomic DNA Translation: AAG35155.1 |
CCDSi | CCDS839.1 [P0DMS8-1] |
PIRi | S38511 |
RefSeqi | NP_000668.1, NM_000677.3 [P0DMS8-1] |
Genome annotation databases
Ensembli | ENST00000241356; ENSP00000241356; ENSG00000282608 [P0DMS8-1] |
GeneIDi | 140 |
KEGGi | hsa:140 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L20463 mRNA Translation: AAA16365.1 L22607 mRNA Translation: AAA35949.1 X76981 mRNA Translation: CAA54288.1 L77730, L77729 Genomic DNA Translation: AAB02790.1 AY136749 mRNA Translation: AAN01275.1 AL390195 Genomic DNA No translation available. BC029831 mRNA Translation: AAH29831.1 AY011231 Genomic DNA Translation: AAG35155.1 |
CCDSi | CCDS839.1 [P0DMS8-1] |
PIRi | S38511 |
RefSeqi | NP_000668.1, NM_000677.3 [P0DMS8-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1OEA | model | - | A | 1-298 | [»] | |
1R7N | model | - | A | 1-318 | [»] | |
SMRi | P0DMS8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Chemistry databases
BindingDBi | P0DMS8 |
ChEMBLi | CHEMBL256 |
DrugBanki | DB00640, Adenosine DB01223, Aminophylline DB00201, Caffeine DB00824, Enprofylline DB12010, Fostamatinib DB05511, Piclidenoson |
DrugCentrali | P0DMS8 |
GuidetoPHARMACOLOGYi | 21 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P0DMS8, 3 sites |
iPTMneti | P0DMS8 |
PhosphoSitePlusi | P0DMS8 |
Genetic variation databases
BioMutai | ADORA3 |
Proteomic databases
MassIVEi | P0DMS8 |
PeptideAtlasi | P0DMS8 |
PRIDEi | P0DMS8 |
Protocols and materials databases
Antibodypediai | 77173, 127 antibodies |
Genome annotation databases
Ensembli | ENST00000241356; ENSP00000241356; ENSG00000282608 [P0DMS8-1] |
GeneIDi | 140 |
KEGGi | hsa:140 |
Organism-specific databases
CTDi | 140 |
DisGeNETi | 140 |
GeneCardsi | ADORA3 |
HGNCi | HGNC:268, ADORA3 |
HPAi | ENSG00000282608, Group enriched (blood, brain) |
MIMi | 600445, gene |
neXtProti | NX_P0DMS8 |
OpenTargetsi | ENSG00000282608 |
VEuPathDBi | HostDB:ENSG00000282608.1 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00990000203639 |
HOGENOMi | CLU_009579_11_5_1 |
OMAi | INCITYF |
OrthoDBi | 550297at2759 |
PhylomeDBi | P0DMS8 |
Enzyme and pathway databases
PathwayCommonsi | P0DMS8 |
Reactomei | R-HSA-417973, Adenosine P1 receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | P0DMS8 |
Miscellaneous databases
BioGRID-ORCSi | 140, 2 hits in 870 CRISPR screens |
GenomeRNAii | 140 |
Pharosi | P0DMS8, Tchem |
PROi | PR:P0DMS8 |
RNActi | P0DMS8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000282608, Expressed in substantia nigra and 150 other tissues |
ExpressionAtlasi | P0DMS8, baseline and differential |
Genevisiblei | P0DMS8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000466, Adeno_A3_rcpt IPR001634, Adenosn_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00555, ADENOSINEA3R PR00424, ADENOSINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AA3R_HUMAN | |
Accessioni | P0DMS8Primary (citable) accession number: P0DMS8 Secondary accession number(s): A2A3P4 Q9BYZ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 2015 |
Last sequence update: | April 1, 2015 | |
Last modified: | February 10, 2021 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants