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Protein

Adenosine receptor A3

Gene

ADORA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 2: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase (PubMed:8234299).1 Publication
Isoform 1: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-417973 Adenosine P1 receptors
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A3
Gene namesi
Name:ADORA3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000282608.1
HGNCiHGNC:268 ADORA3
MIMi600445 gene
neXtProtiNX_P0DMS8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14ExtracellularBy similarityAdd BLAST14
Transmembranei15 – 37Helical; Name=1By similarityAdd BLAST23
Topological domaini38 – 48CytoplasmicBy similarityAdd BLAST11
Transmembranei49 – 72Helical; Name=2By similarityAdd BLAST24
Topological domaini73 – 84ExtracellularBy similarityAdd BLAST12
Transmembranei85 – 106Helical; Name=3By similarityAdd BLAST22
Topological domaini107 – 126CytoplasmicBy similarityAdd BLAST20
Transmembranei127 – 148Helical; Name=4By similarityAdd BLAST22
Topological domaini149 – 177ExtracellularBy similarityAdd BLAST29
Transmembranei178 – 198Helical; Name=5By similarityAdd BLAST21
Topological domaini199 – 231CytoplasmicBy similarityAdd BLAST33
Transmembranei232 – 255Helical; Name=6By similarityAdd BLAST24
Topological domaini256 – 261ExtracellularBy similarity6
Transmembranei262 – 284Helical; Name=7By similarityAdd BLAST23
Topological domaini285 – 318CytoplasmicBy similarityAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi140
OpenTargetsiENSG00000282608

Chemistry databases

ChEMBLiCHEMBL256
DrugBankiDB00640 Adenosine
DB01223 Aminophylline
DB05511 CF-101
DB00824 Enprofylline
GuidetoPHARMACOLOGYi21

Polymorphism and mutation databases

DMDMi1351831

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690101 – 318Adenosine receptor A3Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi83 ↔ 166PROSITE-ProRule annotation
Lipidationi303S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP0DMS8

PTM databases

iPTMnetiP0DMS8
PhosphoSitePlusiP0DMS8

Expressioni

Tissue specificityi

Expressed in the lung and bone. Expressed at lower levels in osteosarcoma tissues (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000282608 Expressed in 129 organ(s), highest expression level in substantia nigra
CleanExiHS_ADORA3
ExpressionAtlasiP0DMS8 differential
GenevisibleiP0DMS8 HS

Interactioni

Chemistry databases

BindingDBiP0DMS8

Structurei

3D structure databases

ProteinModelPortaliP0DMS8
SMRiP0DMS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074524
HOVERGENiHBG106962
KOiK04268
OMAiMRMDYMV
PhylomeDBiP0DMS8
TreeFamiTF334441

Family and domain databases

InterProiView protein in InterPro
IPR000466 Adeno_A3_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00555 ADENOSINEA3R
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 2 (identifier: P0DMS8-1) [UniParc]FASTAAdd to basket
Also known as: A3AR i21 Publication, A3AR1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPNNSTALSL ANVTYITMEI FIGLCAIVGN VLVICVVKLN PSLQTTTFYF
60 70 80 90 100
IVSLALADIA VGVLVMPLAI VVSLGITIHF YSCLFMTCLL LIFTHASIMS
110 120 130 140 150
LLAIAVDRYL RVKLTVRYKR VTTHRRIWLA LGLCWLVSFL VGLTPMFGWN
160 170 180 190 200
MKLTSEYHRN VTFLSCQFVS VMRMDYMVYF SFLTWIFIPL VVMCAIYLDI
210 220 230 240 250
FYIIRNKLSL NLSNSKETGA FYGREFKTAK SLFLVLFLFA LSWLPLSIIN
260 270 280 290 300
CIIYFNGEVP QLVLYMGILL SHANSMMNPI VYAYKIKKFK ETYLLILKAC
310
VVCHPSDSLD TSIEKNSE
Length:318
Mass (Da):36,185
Last modified:April 1, 2015 - v1
Checksum:i690E67986130FC28
GO
Isoform 1 (identifier: P0DMS9-2) [UniParc]FASTAAdd to basket
Also known as: TMIGD3 i11 Publication, A3AR i11 Publication
The sequence of this isoform can be found in the external entry P0DMS9.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: The first exon of TMIGD3 isoform 1 (i1) is shared with the first exon of ADORA3 isoform 2 (A3AR i2, commonly known as A3AR), resulting in a fusion protein.1 Publication
Length:347
Mass (Da):38,976
GO
Isoform 3 (identifier: P0DMS9-1) [UniParc]FASTAAdd to basket
Also known as: TMIGD3 i3, A3AR i3
The sequence of this isoform can be found in the external entry P0DMS9.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:266
Mass (Da):30,327
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YWR0A0A0J9YWR0_HUMAN
Adenosine receptor A3
ADORA3
123Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7A → T in AAA16365 (PubMed:8399349).Curated1
Sequence conflicti175D → V in AAG35155 (PubMed:11214319).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035755105A → T in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs746154553Ensembl.1
Natural variantiVAR_049366248I → L1 PublicationCorresponds to variant dbSNP:rs35511654Ensembl.1
Natural variantiVAR_049367266M → K. Corresponds to variant dbSNP:rs2800889Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20463 mRNA Translation: AAA16365.1
L22607 mRNA Translation: AAA35949.1
X76981 mRNA Translation: CAA54288.1
L77730, L77729 Genomic DNA Translation: AAB02790.1
AY136749 mRNA Translation: AAN01275.1
AL390195 Genomic DNA No translation available.
BC029831 mRNA Translation: AAH29831.1
AY011231 Genomic DNA Translation: AAG35155.1
CCDSiCCDS839.1 [P0DMS8-1]
PIRiS38511
RefSeqiNP_000668.1, NM_000677.3 [P0DMS8-1]
UniGeneiHs.281342

Genome annotation databases

EnsembliENST00000241356; ENSP00000241356; ENSG00000282608 [P0DMS8-1]
GeneIDi140
KEGGihsa:140

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAA3R_HUMAN
AccessioniPrimary (citable) accession number: P0DMS8
Secondary accession number(s): A2A3P4
, P33765, Q6UWU0, Q9BYZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 2015
Last sequence update: April 1, 2015
Last modified: September 12, 2018
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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