Delta-elapitoxin-Cb1a

Functionⁱ

This toxin shifts the voltage-dependence of Nav1.4/SCN4A activation to more hyperpolarised potentials, inhibits inactivation, and produces large ramp currents, consistent with its profound effects on contractile force in an isolated skeletal muscle preparation (PubMed:27763551). This toxin produces large muscle contractions and fasciculations in the indirectly stimulated chick biventer cervicis nerve-muscle assay, which are significantly inhibited by the addition of the sodium channel antagonist tetrodotoxin (PubMed:27763551).1 Publication

GO - Molecular functionⁱ

toxin activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Molecular function

Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Delta-elapitoxin-Cb1a1 Publication Short name: Delta-EPTX-Cb1a1 Publication Alternative name(s): Calliotoxin1 Publication
Organismⁱ	Calliophis bivirgata (Blue Malaysian coral snake) (Maticora bivirgata)
Taxonomic identifierⁱ	8633 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Sauropsida › Sauria › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Elapidae › Elapinae › Calliophis

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000442419	1 – 57	Delta-elapitoxin-Cb1a1 PublicationAdd BLAST		57

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	3 ↔ 22	By similarity
Disulfide bondⁱ	15 ↔ 36	By similarity
Disulfide bondⁱ	40 ↔ 49	By similarity
Disulfide bondⁱ	50 ↔ 55	By similarity

Keywords - PTMⁱ

Disulfide bond

Expressionⁱ

Tissue specificityⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the snake three-finger toxin family. Short-chain subfamily.Curated

Family and domain databases

InterProⁱ	View protein in InterPro IPR035076 Toxin/TOLIP
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00087 Toxin_TOLIP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P0DL82-1 [UniParc]FASTA Add to basket

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LECYDTIFKW HTMTCPEGQN LCFYYFTWRI FLVRGCTATC PVGYSHTHCC 

DTDKCNN

Length:57

Mass (Da):6,739

Last modified:November 22, 2017 - v1

Checksum:ⁱ069ECE4947F75018

GO

Mass spectrometryⁱ

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P0DL82	Muscarinic toxin 1	)	DENAN		66	UniRef50_P81030
Muscarinic toxin alpha		DENPO		66
Muscarinic toxin-like protein 2		NAJKA		65
Muscarinic toxin 4		DENAN		66
Muscarinic toxin 3		DENAN		65
+3

Entry informationⁱ

Entry nameⁱ	3SXNA_CALBG
Accessionⁱ	P0DL82Primary (citable) accession number: P0DL82
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 22, 2017
	Last sequence update:	November 22, 2017
	Last modified:	December 20, 2017
	This is version 2 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Annotation program	Animal Toxin Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Direct protein sequencing

UniProtKB - P0DL82 (3SXNA_CALBG)

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Functionⁱ

GO - Molecular functionⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Expressionⁱ

Tissue specificityⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Family and domain databases

Sequenceⁱ

Mass spectrometryⁱ

Similar proteinsⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0DL82 (3SXNA_CALBG)

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Delta-elapitoxin-Cb1a

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Mass spectrometryⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ