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Protein

Delta-elapitoxin-Cb1a

Gene
N/A
Organism
Calliophis bivirgata (Blue Malaysian coral snake) (Maticora bivirgata)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This toxin shifts the voltage-dependence of Nav1.4/SCN4A activation to more hyperpolarised potentials, inhibits inactivation, and produces large ramp currents, consistent with its profound effects on contractile force in an isolated skeletal muscle preparation (PubMed:27763551). This toxin produces large muscle contractions and fasciculations in the indirectly stimulated chick biventer cervicis nerve-muscle assay, which are significantly inhibited by the addition of the sodium channel antagonist tetrodotoxin (PubMed:27763551).1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-elapitoxin-Cb1a1 Publication
Short name:
Delta-EPTX-Cb1a1 Publication
Alternative name(s):
Calliotoxin1 Publication
OrganismiCalliophis bivirgata (Blue Malaysian coral snake) (Maticora bivirgata)
Taxonomic identifieri8633 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeCalliophis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004424191 – 57Delta-elapitoxin-Cb1a1 PublicationAdd BLAST57

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 22By similarity
Disulfide bondi15 ↔ 36By similarity
Disulfide bondi40 ↔ 49By similarity
Disulfide bondi50 ↔ 55By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR035076 Toxin/TOLIP
PfamiView protein in Pfam
PF00087 Toxin_TOLIP, 1 hit

Sequencei

Sequence statusi: Complete.

P0DL82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LECYDTIFKW HTMTCPEGQN LCFYYFTWRI FLVRGCTATC PVGYSHTHCC

DTDKCNN
Length:57
Mass (Da):6,739
Last modified:November 22, 2017 - v1
Checksum:i069ECE4947F75018
GO

Mass spectrometryi

Molecular mass is 6725.9 Da from positions 1 - 57. Determined by ESI. Monoisotopic mass.1 Publication

Similar proteinsi

Entry informationi

Entry namei3SXNA_CALBG
AccessioniPrimary (citable) accession number: P0DL82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: November 22, 2017
Last modified: December 20, 2017
This is version 2 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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