UniProtKB - P0DL82 (3SXNA_CALBG)
Protein
Delta-elapitoxin-Cb1a
Gene
N/A
Organism
Calliophis bivirgatus (Blue Malaysian coral snake) (Maticora bivirgata)
Status
Functioni
This toxin shifts the voltage-dependence of Nav1.4/SCN4A activation to more hyperpolarised potentials, inhibits inactivation, and produces large ramp currents, consistent with its profound effects on contractile force in an isolated skeletal muscle preparation (PubMed:27763551). This toxin produces large muscle contractions and fasciculations in the indirectly stimulated chick biventer cervicis nerve-muscle assay, which are significantly inhibited by the addition of the sodium channel antagonist tetrodotoxin (PubMed:27763551).1 Publication
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Delta-elapitoxin-Cb1a1 PublicationShort name: Delta-EPTX-Cb1a1 Publication Alternative name(s): Calliotoxin1 Publication |
Organismi | Calliophis bivirgatus (Blue Malaysian coral snake) (Maticora bivirgata) |
Taxonomic identifieri | 8633 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Elapidae › Elapinae › Calliophis |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000442419 | 1 – 57 | Delta-elapitoxin-Cb1a1 PublicationAdd BLAST | 57 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 3 ↔ 22 | By similarity | ||
Disulfide bondi | 15 ↔ 36 | By similarity | ||
Disulfide bondi | 40 ↔ 49 | By similarity | ||
Disulfide bondi | 50 ↔ 55 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Family & Domainsi
Sequence similaritiesi
Family and domain databases
InterProi | View protein in InterPro IPR035076 Toxin/TOLIP |
Pfami | View protein in Pfam PF00087 Toxin_TOLIP, 1 hit |
i Sequence
Sequence statusi: Complete.
P0DL82-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
LECYDTIFKW HTMTCPEGQN LCFYYFTWRI FLVRGCTATC PVGYSHTHCC
DTDKCNN
Mass spectrometryi
Molecular mass is 6725.9 Da from positions 1 - 57. Determined by ESI. Monoisotopic mass.1 Publication
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR035076 Toxin/TOLIP |
Pfami | View protein in Pfam PF00087 Toxin_TOLIP, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | 3SXNA_CALBG | |
Accessioni | P0DL82Primary (citable) accession number: P0DL82 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2017 |
Last sequence update: | November 22, 2017 | |
Last modified: | October 10, 2018 | |
This is version 3 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families