UniProtKB - P0DL43 (KAX2E_HETGR)
Protein
Potassium channel toxin alpha-KTx 2.14
Gene
N/A
Organism
Heteroctenus garridoi (Cuban scorpion) (Rhopalurus garridoi)
Status
Functioni
Reversibly blocks hKv1.1/KCNA1 (50% inhibition of current at 1 µM). Seems not to be voltage-dependent.1 Publication
Miscellaneous
Does not block hKv1.4/KCNA4, hERG1/KCNH2 and EAG/KCNH1 currents, at 1 µM.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 27 | Basic residue of the functional dyadBy similarity | 1 | |
Sitei | 36 | Aromatic residue of the functional dyadBy similarity | 1 |
GO - Molecular functioni
- ion channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium channel toxin alpha-KTx 2.141 Publication |
Organismi | Heteroctenus garridoi (Cuban scorpion) (Rhopalurus garridoi) |
Taxonomic identifieri | 2203757 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Heteroctenus |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000433139 | 1 – 37 | Potassium channel toxin alpha-KTx 2.141 PublicationAdd BLAST | 37 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 7 ↔ 28 | By similarity | ||
Disulfide bondi | 13 ↔ 33 | By similarity | ||
Disulfide bondi | 17 ↔ 35 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Family & Domainsi
Domaini
Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).By similarity
Sequence similaritiesi
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 02 subfamily.Curated
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR001947 Scorpion_toxinS_K_inh |
Pfami | View protein in Pfam PF00451 Toxin_2, 1 hit |
PRINTSi | PR00286 CHARYBDTOXIN |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS01138 SCORP_SHORT_TOXIN, 1 hit |
i Sequence
Sequence statusi: Complete.
Similar proteinsi
Cross-referencesi
3D structure databases
SMRi | P0DL43 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR001947 Scorpion_toxinS_K_inh |
Pfami | View protein in Pfam PF00451 Toxin_2, 1 hit |
PRINTSi | PR00286 CHARYBDTOXIN |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS01138 SCORP_SHORT_TOXIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KAX2E_HETGR | |
Accessioni | P0DL43Primary (citable) accession number: P0DL43 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 27, 2015 |
Last sequence update: | May 27, 2015 | |
Last modified: | July 3, 2019 | |
This is version 11 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries - SIMILARITY comments
Index of protein domains and families