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Protein

Fulvonin

Gene
N/A
Organism
Cyphononyx dorsalis (Spider wasp) (Cyphononyx fulvognathus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits angiotensin-converting enzyme (ACE) with a Ki of 1.2 µM, targets B1 bradykinin receptors (BDKRB1), and potentiates the smooth muscle contraction elicited by bradykinin. In vivo, induces hyperalgesic effects in living rats after intraplantar injection.1 Publication

Miscellaneous

Is hydrolyzed by angiotensin-converting enzyme (ACE) by only 7.5% (compared to bradykinin).1 Publication
Not able to contract smooth muscle preparation (ileum).1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionBradykinin receptor impairing toxin, G-protein coupled receptor impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Fulvonin
OrganismiCyphononyx dorsalis (Spider wasp) (Cyphononyx fulvognathus)
Taxonomic identifieri246266 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataPompiloideaPompilidaePepsinaeCyphononyx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00004241411 – 11FulvoninAdd BLAST11

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Sequence similaritiesi

Belongs to the bradykinin-related peptide family.Curated

Sequencei

Sequence statusi: Complete.

Length:11
Mass (Da):1,244
Last modified:October 16, 2013 - v1
Checksum:i5ADDBCB2D3386407
GO

Mass spectrometryi

Molecular mass is 1243.8 Da from positions 1 - 11. Determined by MALDI. Monoisotopic mass.1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiBRKF_CYPDO
AccessioniPrimary (citable) accession number: P0DL32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: October 16, 2013
Last modified: November 22, 2017
This is version 10 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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