UniProtKB - P0DL06 (BPPDD_BOTJA)
Protein
Bradykinin-potentiating peptide 13d
Gene
N/A
Organism
Bothrops jararaca (Jararaca) (Bothrops jajaraca)
Status
Functioni
This peptide both inhibits the activity of the angiotensin-converting enzyme (ACE) and enhances the action of bradykinin by inhibiting the peptidases that inactivate it. It acts as an indirect hypotensive agent (By similarity).By similarity
GO - Molecular functioni
- metalloendopeptidase inhibitor activity Source: UniProtKB-KW
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- regulation of blood pressure Source: UniProtKB-KW
Keywordsi
Molecular function | Hypotensive agent, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Bradykinin-potentiating peptide 13dShort name: BPP-13d |
Organismi | Bothrops jararaca (Jararaca) (Bothrops jajaraca) |
Taxonomic identifieri | 8724 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Crotalinae › Bothrops |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000421920 | 1 – 13 | Bradykinin-potentiating peptide 13dAdd BLAST | 13 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | Pyrrolidone carboxylic acid1 Publication | 1 |
Keywords - PTMi
Pyrrolidone carboxylic acidExpressioni
Tissue specificityi
Expressed by the venom gland.
Family & Domainsi
Sequence similaritiesi
Belongs to the bradykinin-potentiating peptide family.Curated
i Sequence
Sequence statusi: Complete.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence uncertaintyi | 9 | I or L | 1 |
Mass spectrometryi
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
ProtoNeti | Search... |
Entry informationi
Entry namei | BPPDD_BOTJA | |
Accessioni | P0DL06Primary (citable) accession number: P0DL06 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2013 |
Last sequence update: | April 3, 2013 | |
Last modified: | November 22, 2017 | |
This is version 11 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families