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Protein

Conantokin Rl-C

Gene
N/A
Organism
Conus rolani (Cone snail)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin has antagonist activity on NR2B/GRIN2B (IC50=1.4 µM) and NR2A/GRIN2A (IC50=2.9 µM) subunits, when tested on rat receptors.1 Publication

Miscellaneous

The mature peptide does not contain cysteine residue.Curated
Has no antagonist activity on NR2C/GRIN2C, and NR2D/GRIN2D subunits.1 Publication

Cofactori

Ca2+By similarity, Mg2+By similarityNote: Divalent cations stabilize the toxin the in alpha-helix conformation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi81Divalent metal cation; via 4-carboxyglutamateBy similarity1
Metal bindingi85Divalent metal cation; via 4-carboxyglutamateBy similarity1
Metal bindingi89Divalent metal cation; via 4-carboxyglutamateBy similarity1
Metal bindingi93Divalent metal cation; via 4-carboxyglutamateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Ionotropic glutamate receptor inhibitor, Neurotoxin, Postsynaptic neurotoxin, Toxin
LigandCalcium, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Conantokin Rl-CCurated
Short name:
Con Rl-CCurated
Short name:
ConRl-C1 Publication
OrganismiConus rolani (Cone snail)
Taxonomic identifieri745791 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusAsprella

Organism-specific databases

ConoServeri5850 Conantokin-Rl3 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000042189622 – 781 PublicationAdd BLAST57
PeptideiPRO_000042189779 – 96Conantokin Rl-C1 PublicationAdd BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei814-carboxyglutamateBy similarity1 Publication1
Modified residuei824-carboxyglutamateBy similarity1 Publication1
Modified residuei854-carboxyglutamateBy similarity1 Publication1
Modified residuei894-carboxyglutamateBy similarity1 Publication1
Modified residuei934-carboxyglutamateBy similarity1 Publication1
Modified residuei96Asparagine amideBy similarity1 Publication1

Keywords - PTMi

Amidation, Gamma-carboxyglutamic acid

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the conotoxin B superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR005918 Conantokin_CS
PROSITEiView protein in PROSITE
PS60025 CONANTOKIN, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DKZ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLYTYLYLL VPLVTFHLIL GTGTLDHGDA LTERRSADAT ALKPEPVLLQ
60 70 80 90
KSSARSTDDN GKDTQMKRIF KKRRNKARGE EELSENAVEF ARELAN
Length:96
Mass (Da):10,864
Last modified:April 3, 2013 - v1
Checksum:i37B5511265166809
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei961

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri5850 Conantokin-Rl3 precursor

Family and domain databases

InterProiView protein in InterPro
IPR005918 Conantokin_CS
PROSITEiView protein in PROSITE
PS60025 CONANTOKIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCKR1C_CONRO
AccessioniPrimary (citable) accession number: P0DKZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: April 3, 2013
Last modified: September 12, 2018
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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