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Protein

Bifunctional hemolysin/adenylate cyclase

Gene

cya

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by host calmodulin.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi349 – 356ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Lyase, Toxin
Biological processcAMP biosynthesis, Cytolysis, Hemolysis, Virulence
LigandATP-binding, Calcium, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BPER257313:BP0760_11-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bifunctional hemolysin/adenylate cyclase
Alternative name(s):
AC-HLY
ACT
Cyclolysin
Cleaved into the following 2 chains:
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cya
Synonyms:cyaA
Ordered Locus Names:BP0760
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri257313 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002676 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi188D → E, N, Y or H: Loss of activity. 1
Mutagenesisi190D → N, Y or H: Loss of activity. 1
Mutagenesisi298H → R, P or L: Loss of activity. 1
Mutagenesisi301E → Q or K: Loss of activity. 1

Keywords - Diseasei

Whooping cough

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000013201 – 312Calmodulin-sensitive adenylate cyclaseAdd BLAST312
ChainiPRO_0000001321313 – 1706HemolysinSequence analysisAdd BLAST1394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi860N6-palmitoyl lysine1 Publication1
Lipidationi983N6-palmitoyl lysine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Released in a processed form.
Palmitoylated by CyaC. The toxin only becomes active when modified in position Lys-983.2 Publications

Keywords - PTMi

Lipoprotein, Palmitate

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P0DKX7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
257313.BP0760

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11706
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YRTX-ray2.10A1-364[»]
1YRUX-ray2.50A1-364[»]
1ZOTX-ray2.20A7-364[»]
2COLX-ray2.20A7-362[»]
5CXLX-ray1.45A/B1529-1681[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P0DKX7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0DKX7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1014 – 1031Hemolysin-type calcium-binding 1Add BLAST18
Repeati1032 – 1049Hemolysin-type calcium-binding 2Add BLAST18
Repeati1050 – 1067Hemolysin-type calcium-binding 3Add BLAST18
Repeati1155 – 1172Hemolysin-type calcium-binding 4Add BLAST18
Repeati1173 – 1190Hemolysin-type calcium-binding 5Add BLAST18
Repeati1279 – 1296Hemolysin-type calcium-binding 6Add BLAST18
Repeati1297 – 1314Hemolysin-type calcium-binding 7Add BLAST18
Repeati1315 – 1332Hemolysin-type calcium-binding 8Add BLAST18
Repeati1335 – 1352Hemolysin-type calcium-binding 9Add BLAST18
Repeati1411 – 1428Hemolysin-type calcium-binding 10Add BLAST18
Repeati1429 – 1446Hemolysin-type calcium-binding 11Add BLAST18
Repeati1447 – 1464Hemolysin-type calcium-binding 12Add BLAST18
Repeati1468 – 1484Hemolysin-type calcium-binding 13Add BLAST17
Repeati1537 – 1554Hemolysin-type calcium-binding 14Add BLAST18
Repeati1555 – 1572Hemolysin-type calcium-binding 15Add BLAST18
Repeati1573 – 1590Hemolysin-type calcium-binding 16Add BLAST18
Repeati1603 – 1620Hemolysin-type calcium-binding 17Add BLAST18

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 399A, catalyticAdd BLAST399
Regioni400 – 912B, Ala/Gly-richAdd BLAST513
Regioni913 – 1656CAdd BLAST744
Regioni1657 – 1706D, Asp/Gly-richAdd BLAST50

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Gly-rich region is probably involved in binding calcium, which is required for target cell-binding or cytolytic activity.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the adenylyl cyclase class-2 family.Curated
In the C-terminal section; belongs to the RTX prokaryotic toxin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4107VZP Bacteria
COG2931 LUCA

KEGG Orthology (KO)

More...
KOi
K22944

Identification of Orthologs from Complete Genome Data

More...
OMAi
PMMPVGQ

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.150.10.10, 6 hits
3.90.1760.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035099 Anthrax_toxin_C-terminal
IPR005165 Anthrax_toxin_edema_cen
IPR037017 Anthrax_toxin_edema_cen_sf
IPR018511 Hemolysin-typ_Ca-bd_CS
IPR001343 Hemolysn_Ca-bd
IPR018504 RTX_N
IPR003995 RTX_toxin_determinant-A
IPR011049 Serralysin-like_metalloprot_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03497 Anthrax_toxA, 1 hit
PF00353 HemolysinCabind, 8 hits
PF02382 RTX, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01488 RTXTOXINA

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51120 SSF51120, 5 hits
SSF81298 SSF81298, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00330 HEMOLYSIN_CALCIUM, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0DKX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQQSHQAGYA NAADRESGIP AAVLDGIKAV AKEKNATLMF RLVNPHSTSL
60 70 80 90 100
IAEGVATKGL GVHAKSSDWG LQAGYIPVNP NLSKLFGRAP EVIARADNDV
110 120 130 140 150
NSSLAHGHTA VDLTLSKERL DYLRQAGLVT GMADGVVASN HAGYEQFEFR
160 170 180 190 200
VKETSDGRYA VQYRRKGGDD FEAVKVIGNA AGIPLTADID MFAIMPHLSN
210 220 230 240 250
FRDSARSSVT SGDSVTDYLA RTRRAASEAT GGLDRERIDL LWKIARAGAR
260 270 280 290 300
SAVGTEARRQ FRYDGDMNIG VITDFELEVR NALNRRAHAV GAQDVVQHGT
310 320 330 340 350
EQNNPFPEAD EKIFVVSATG ESQMLTRGQL KEYIGQQRGE GYVFYENRAY
360 370 380 390 400
GVAGKSLFDD GLGAAPGVPS GRSKFSPDVL ETVPASPGLR RPSLGAVERQ
410 420 430 440 450
DSGYDSLDGV GSRSFSLGEV SDMAAVEAAE LEMTRQVLHA GARQDDAEPG
460 470 480 490 500
VSGASAHWGQ RALQGAQAVA AAQRLVHAIA LMTQFGRAGS TNTPQEAASL
510 520 530 540 550
SAAVFGLGEA SSAVAETVSG FFRGSSRWAG GFGVAGGAMA LGGGIAAAVG
560 570 580 590 600
AGMSLTDDAP AGQKAAAGAE IALQLTGGTV ELASSIALAL AAARGVTSGL
610 620 630 640 650
QVAGASAGAA AGALAAALSP MEIYGLVQQS HYADQLDKLA QESSAYGYEG
660 670 680 690 700
DALLAQLYRD KTAAEGAVAG VSAVLSTVGA AVSIAAAASV VGAPVAVVTS
710 720 730 740 750
LLTGALNGIL RGVQQPIIEK LANDYARKID ELGGPQAYFE KNLQARHEQL
760 770 780 790 800
ANSDGLRKML ADLQAGWNAS SVIGVQTTEI SKSALELAAI TGNADNLKSV
810 820 830 840 850
DVFVDRFVQG ERVAGQPVVL DVAAGGIDIA SRKGERPALT FITPLAAPGE
860 870 880 890 900
EQRRRTKTGK SEFTTFVEIV GKQDRWRIRD GAADTTIDLA KVVSQLVDAN
910 920 930 940 950
GVLKHSIKLD VIGGDGDDVV LANASRIHYD GGAGTNTVSY AALGRQDSIT
960 970 980 990 1000
VSADGERFNV RKQLNNANVY REGVATQTTA YGKRTENVQY RHVELARVGQ
1010 1020 1030 1040 1050
LVEVDTLEHV QHIIGGAGND SITGNAHDNF LAGGSGDDRL DGGAGNDTLV
1060 1070 1080 1090 1100
GGEGQNTVIG GAGDDVFLQD LGVWSNQLDG GAGVDTVKYN VHQPSEERLE
1110 1120 1130 1140 1150
RMGDTGIHAD LQKGTVEKWP ALNLFSVDHV KNIENLHGSR LNDRIAGDDQ
1160 1170 1180 1190 1200
DNELWGHDGN DTIRGRGGDD ILRGGLGLDT LYGEDGNDIF LQDDETVSDD
1210 1220 1230 1240 1250
IDGGAGLDTV DYSAMIHPGR IVAPHEYGFG IEADLSREWV RKASALGVDY
1260 1270 1280 1290 1300
YDNVRNVENV IGTSMKDVLI GDAQANTLMG QGGDDTVRGG DGDDLLFGGD
1310 1320 1330 1340 1350
GNDMLYGDAG NDTLYGGLGD DTLEGGAGND WFGQTQAREH DVLRGGDGVD
1360 1370 1380 1390 1400
TVDYSQTGAH AGIAAGRIGL GILADLGAGR VDKLGEAGSS AYDTVSGIEN
1410 1420 1430 1440 1450
VVGTELADRI TGDAQANVLR GAGGADVLAG GEGDDVLLGG DGDDQLSGDA
1460 1470 1480 1490 1500
GRDRLYGEAG DDWFFQDAAN AGNLLDGGDG RDTVDFSGPG RGLDAGAKGV
1510 1520 1530 1540 1550
FLSLGKGFAS LMDEPETSNV LRNIENAVGS ARDDVLIGDA GANVLNGLAG
1560 1570 1580 1590 1600
NDVLSGGAGD DVLLGDEGSD LLSGDAGNDD LFGGQGDDTY LFGVGYGHDT
1610 1620 1630 1640 1650
IYESGGGHDT IRINAGADQL WFARQGNDLE IRILGTDDAL TVHDWYRDAD
1660 1670 1680 1690 1700
HRVEIIHAAN QAVDQAGIEK LVEAMAQYPD PGAAAAAPPA ARVPDTLMQS

LAVNWR
Length:1,706
Mass (Da):177,521
Last modified:March 6, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC1FD3D46CABCEF39
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX640413 Genomic DNA Translation: CAE41066.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S00893 OYBRC

NCBI Reference Sequences

More...
RefSeqi
NP_879578.1, NC_002929.2
WP_010929995.1, NC_002929.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAE41066; CAE41066; BP0760

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2664492

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bpe:BP0760

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|257313.5.peg.813

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640413 Genomic DNA Translation: CAE41066.1
PIRiS00893 OYBRC
RefSeqiNP_879578.1, NC_002929.2
WP_010929995.1, NC_002929.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YRTX-ray2.10A1-364[»]
1YRUX-ray2.50A1-364[»]
1ZOTX-ray2.20A7-364[»]
2COLX-ray2.20A7-362[»]
5CXLX-ray1.45A/B1529-1681[»]
ProteinModelPortaliP0DKX7
SMRiP0DKX7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0DKX7, 1 interactor
STRINGi257313.BP0760

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE41066; CAE41066; BP0760
GeneIDi2664492
KEGGibpe:BP0760
PATRICifig|257313.5.peg.813

Phylogenomic databases

eggNOGiENOG4107VZP Bacteria
COG2931 LUCA
KOiK22944
OMAiPMMPVGQ

Enzyme and pathway databases

BioCyciBPER257313:BP0760_11-MONOMER

Family and domain databases

Gene3Di2.150.10.10, 6 hits
3.90.1760.10, 1 hit
InterProiView protein in InterPro
IPR035099 Anthrax_toxin_C-terminal
IPR005165 Anthrax_toxin_edema_cen
IPR037017 Anthrax_toxin_edema_cen_sf
IPR018511 Hemolysin-typ_Ca-bd_CS
IPR001343 Hemolysn_Ca-bd
IPR018504 RTX_N
IPR003995 RTX_toxin_determinant-A
IPR011049 Serralysin-like_metalloprot_C
PfamiView protein in Pfam
PF03497 Anthrax_toxA, 1 hit
PF00353 HemolysinCabind, 8 hits
PF02382 RTX, 1 hit
PRINTSiPR01488 RTXTOXINA
SUPFAMiSSF51120 SSF51120, 5 hits
SSF81298 SSF81298, 1 hit
PROSITEiView protein in PROSITE
PS00330 HEMOLYSIN_CALCIUM, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYAA_BORPE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0DKX7
Secondary accession number(s): P15318
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: March 6, 2013
Last modified: December 5, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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