UniProtKB - P0DKX6 (CYAB_BORP1)
Protein
Cyclolysin secretion/processing ATP-binding protein CyaB
Gene
cyaB
Organism
Bordetella pertussis (strain ATCC 9797 / DSM 5571 / NCTC 10739 / 18323)
Status
Functioni
Involved in the export of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin).1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 505 – 512 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled transmembrane transporter activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- cysteine-type peptidase activity Source: UniProtKB-KW
GO - Biological processi
- hemolysis in other organism Source: UniProtKB-KW
- protein secretion by the type I secretion system Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease, Translocase |
Biological process | Cytolysis, Hemolysis, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | BPER568706:G1HBS-479-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:cyaB Ordered Locus Names:BN118_0469 |
Organismi | Bordetella pertussis (strain ATCC 9797 / DSM 5571 / NCTC 10739 / 18323) |
Taxonomic identifieri | 568706 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein PROSITE-ProRule annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- type I protein secretion system complex Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 160 – 180 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 194 – 214 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 272 – 292 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 298 – 318 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 367 – 387 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 390 – 410 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000421302 | 1 – 712 | Cyclolysin secretion/processing ATP-binding protein CyaBAdd BLAST | 712 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 128 | Peptidase C39PROSITE-ProRule annotationAdd BLAST | 122 | |
Domaini | 157 – 439 | ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST | 283 | |
Domaini | 471 – 706 | ABC transporterPROSITE-ProRule annotationAdd BLAST | 236 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. Cyclolysin exporter (TC 3.A.1.109.2) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
CDDi | cd02417, Peptidase_C39_likeA, 1 hit |
Gene3Di | 1.20.1560.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR010132, ATPase_T1SS_HlyB IPR027417, P-loop_NTPase IPR005074, Peptidase_C39 IPR039395, Peptidase_C39-like_A IPR039421, Type_1_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 1 hit PF00005, ABC_tran, 1 hit PF03412, Peptidase_C39, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
TIGRFAMsi | TIGR01846, type_I_sec_HlyB, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS50990, PEPTIDASE_C39, 1 hit |
i Sequence
Sequence statusi: Complete.
P0DKX6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSPVAQCAS VPDSGLLCLV MLARYHGLAA DPEQLRHEFA EQAFCSETIQ
60 70 80 90 100
LAARRVGLKV RRHRPAPARL PRAPLPAIAL DRQGGYFVLA RFEPGADQAV
110 120 130 140 150
LIQRPGQAPA RLGQAEFEAL WAGELLLCAC AASPTQALAR FDFSWFIPAL
160 170 180 190 200
VKHRHLIGEV LLISLVLQFI SLLTPLFFQV VMDKVLVNNA METLNVIAVG
210 220 230 240 250
FLAAILFEAL LTGIRTYLFA HTSSKLDVEL GARLYAHLLR LPLAYFQARR
260 270 280 290 300
VGDSVARVRE LEHIRAFLTG NAVTVLLDVV FSVVFIAVMF FYSVKLTLVV
310 320 330 340 350
LAALPCYFLL SLVLTPVLRR RLDVKFNRGA ENQAFLVETV SGIDTVKSLA
360 370 380 390 400
VEPQWQRNWD RQLAGYVAAG LSVANVAMLA NTGVTLISRL VALGVLWVGA
410 420 430 440 450
TEVVAQRMTV GELVAFNMLS GHVTQPVIRL AQLWNDFQQT GVSMQRLGDI
460 470 480 490 500
LNCRTEVAGD KAQLPALRGS IELDRVSFRY RPDAADALRN VSLRIAPGEV
510 520 530 540 550
VGVVGRSGSG KSTLTRLIQR MFVADRGRVL IDGHDIGIVD SASLRRQLGV
560 570 580 590 600
VLQESTLFNR SVRDNIALTR PGASMHEVVA AARLAGAHEF ICQLPEGYDT
610 620 630 640 650
MLGENGVGLS GGQRQRIGIA RALIHRPRVL ILDEATSALD YESEHIIQRN
660 670 680 690 700
MRDICDGRTV IIIAHRLSAV RCADRIVVME GGEVAECGSH ETLLAAGGLY
710
ARLQALQAGE AG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 90 | A → VP in CAA32412 (PubMed:2905265).Curated | 1 | |
Sequence conflicti | 198 | A → T in CAA32412 (PubMed:2905265).Curated | 1 | |
Sequence conflicti | 323 | D → H in CAA32412 (PubMed:2905265).Curated | 1 | |
Sequence conflicti | 391 – 406 | VALGV…EVVAQ → LRWESCGWAHRGGRA in CAA32412 (PubMed:2905265).CuratedAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14199 Genomic DNA Translation: CAA32412.1 HE965805 Genomic DNA No translation available. |
PIRi | S02386, BVBRCB |
RefSeqi | WP_041166126.1, NC_018518.1 |
Genome annotation databases
GeneIDi | 45387798 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14199 Genomic DNA Translation: CAA32412.1 HE965805 Genomic DNA No translation available. |
PIRi | S02386, BVBRCB |
RefSeqi | WP_041166126.1, NC_018518.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 45387798 |
Enzyme and pathway databases
BioCyci | BPER568706:G1HBS-479-MONOMER |
Family and domain databases
CDDi | cd02417, Peptidase_C39_likeA, 1 hit |
Gene3Di | 1.20.1560.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR010132, ATPase_T1SS_HlyB IPR027417, P-loop_NTPase IPR005074, Peptidase_C39 IPR039395, Peptidase_C39-like_A IPR039421, Type_1_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 1 hit PF00005, ABC_tran, 1 hit PF03412, Peptidase_C39, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
TIGRFAMsi | TIGR01846, type_I_sec_HlyB, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS50990, PEPTIDASE_C39, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CYAB_BORP1 | |
Accessioni | P0DKX6Primary (citable) accession number: P0DKX6 Secondary accession number(s): P18770 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2013 |
Last sequence update: | March 6, 2013 | |
Last modified: | April 7, 2021 | |
This is version 31 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |