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Protein

Conoporin-Cn1

Gene
N/A
Organism
Conus consors (Singed cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Pore-forming protein that forms pores of around 1 nm and causes cardiac stimulation and hemolysis.By similarity

Miscellaneous

Found in injectable (milked) (IV) venom.1 Publication
The mature peptide contains 1 cysteine residue.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionToxin
Biological processCytolysis, Hemolysis, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Conoporin-Cn11 Publication
OrganismiConus consors (Singed cone)
Taxonomic identifieri101297 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPionoconus

Organism-specific databases

ConoServeri5534 Conoporin-Cn1 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted, Target cell membrane, Target membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000041989724 – 248Conoporin-Cn1Add BLAST225

Post-translational modificationi

9 isoforms are detected in the injectable venom, mainly corresponding to different oxidative states.

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the actinoporin family. Conoidea subfamily.Curated

Keywords - Domaini

Signal, Transmembrane

Family and domain databases

Gene3Di2.60.270.20, 1 hit
InterProiView protein in InterPro
IPR015926 Cytolysin/lectin
SUPFAMiSSF63724 SSF63724, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DKQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVQFPALKT MVTVFLLLMG NMSPVVMKSS IPLRKVKMVA SKVVTPGSSL
60 70 80 90 100
YGVALKDLAD TSYNITCTLQ VENWIRYRLI VPSVQMVYGV VTTTPIAIEP
110 120 130 140 150
AKREAFAVRK TSDTASGVAG SVSWELEKAR RRFVIMWSVP DNFNSFGYWM
160 170 180 190 200
GLGMTREGLV DPDKDWYGQM YSGSSDGDLT FTRKDFSYNT DSIIYSNDKF
210 220 230 240
EVEGDMTNTQ HAQIKIVIRP SSNNWKDLAP KIRRKLKKKP KPARQRDN
Length:248
Mass (Da):27,969
Last modified:October 31, 2012 - v1
Checksum:iC6AF74F374DBE68E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE856388 mRNA Translation: CCI55501.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE856388 mRNA Translation: CCI55501.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri5534 Conoporin-Cn1 precursor

Family and domain databases

Gene3Di2.60.270.20, 1 hit
InterProiView protein in InterPro
IPR015926 Cytolysin/lectin
SUPFAMiSSF63724 SSF63724, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACTP_CONCN
AccessioniPrimary (citable) accession number: P0DKQ8
Secondary accession number(s): S6CRD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2012
Last sequence update: October 31, 2012
Last modified: September 12, 2018
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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