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Protein

Omega-conotoxin-like CnVIIJ

Gene
N/A
Organism
Conus consors (Singed cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).By similarity

Miscellaneous

Found in injectable (milked) (IV) venom.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-conotoxin-like CnVIIJ
OrganismiConus consors (Singed cone)
Taxonomic identifieri101297 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPionoconus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00004198891 – 35Omega-conotoxin-like CnVIIJAdd BLAST35

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 19By similarity
Disulfide bondi11 ↔ 22By similarity
Disulfide bondi18 ↔ 29By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiP0DKQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin O1 superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR012321 Conotoxin_omega-typ_CS
PROSITEiView protein in PROSITE
PS60004 OMEGA_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

P0DKQ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30 
STSCMKAGSY CRSTTRTCCG YCAYFGKFCI DFPSN
Length:35
Mass (Da):3,860
Last modified:October 31, 2012 - v1
Checksum:iDBA5C68F2CC19C55
GO

Mass spectrometryi

Molecular mass is 3851.49 Da from positions 1 - 35. Determined by ESI. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

SMRiP0DKQ6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR012321 Conotoxin_omega-typ_CS
PROSITEiView protein in PROSITE
PS60004 OMEGA_CONOTOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM7J_CONCN
AccessioniPrimary (citable) accession number: P0DKQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2012
Last sequence update: October 31, 2012
Last modified: October 10, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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