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Protein

Omega-conotoxin-like CnVIIE

Gene
N/A
Organism
Conus consors (Singed cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).By similarity

Miscellaneous

Found in injectable (milked) (IV) venom.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-conotoxin-like CnVIIE
Cleaved into the following chain:
Alternative name(s):
[Hyp7-CnVIIC]
OrganismiConus consors (Singed cone)
Taxonomic identifieri101297 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPionoconus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00004198831 – 26Omega-conotoxin-like CnVIIEAdd BLAST26
PeptideiPRO_00004198841 – 25Omega-conotoxin-like CnVIICAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1 ↔ 16By similarity
Modified residuei74-hydroxyproline; partial1 Publication1
Disulfide bondi8 ↔ 20By similarity
Disulfide bondi15 ↔ 25By similarity
Modified residuei25Cysteine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiP0DKQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin M superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR012321 Conotoxin_omega-typ_CS
PROSITEiView protein in PROSITE
PS60004 OMEGA_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DKQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20 
CKGTGKPCSR IAYNCCTGSC RSGKCG
Length:26
Mass (Da):2,641
Last modified:October 31, 2012 - v1
Checksum:i9B25B8DC370583DF
GO

Mass spectrometryi

Molecular mass is 2649.06 Da from positions 1 - 26. Determined by ESI. CnVIIE.1 Publication
Molecular mass is 2575.052 Da from positions 1 - 25. Determined by ESI. CnVIIC.1 Publication
Molecular mass is 2591.03 Da from positions 1 - 25. Determined by ESI. [Hyp7]-CnVIIC.1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

SMRiP0DKQ3
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR012321 Conotoxin_omega-typ_CS
PROSITEiView protein in PROSITE
PS60004 OMEGA_CONOTOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM7E_CONCN
AccessioniPrimary (citable) accession number: P0DKQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2012
Last sequence update: October 31, 2012
Last modified: October 10, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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