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Protein

Conotoxin fe11.1

Gene
N/A
Organism
Conus ferrugineus (Cone snail)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

This sequence has been copied from a figure, and no information except the name are available for it. The species, and the sequence origin are only deduced to be C.ferrugineus and nucleotide sequence.Curated

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin fe11.1
OrganismiConus ferrugineus (Cone snail)
Taxonomic identifieri379542 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusStrategoconus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000041983226 – 58Conotoxin fe11.1Add BLAST33
PropeptideiPRO_000041983362 – 74By similarityAdd BLAST13

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 42By similarity
Disulfide bondi35 ↔ 47By similarity
Disulfide bondi41 ↔ 51By similarity
Disulfide bondi46 ↔ 55By similarity
Modified residuei58Proline amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiP0DKM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I2 superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR020242 Conotoxin_I2-superfamily
PfamiView protein in Pfam
PF17557 Conotoxin_I2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD267162 Conotoxin_I2-superfamily, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DKM1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMFRVTSVGC FLLVIVLLHV AAVTSDDCRP EAAYCEYNEQ CCIDKCCQAS
60 70
CSDACRTPGK RVHGHGLLRF FGQR
Length:74
Mass (Da):8,232
Last modified:October 31, 2012 - v1
Checksum:i8FE7FB37A01A6C75
GO

Similar proteinsi

Cross-referencesi

3D structure databases

SMRiP0DKM1
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR020242 Conotoxin_I2-superfamily
PfamiView protein in Pfam
PF17557 Conotoxin_I2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD267162 Conotoxin_I2-superfamily, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI2B1_CONFR
AccessioniPrimary (citable) accession number: P0DKM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2012
Last sequence update: October 31, 2012
Last modified: October 10, 2018
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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