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Entry version 33 (29 Sep 2021)
Sequence version 1 (20 Jan 2016)
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Protein

Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2

Gene

FIS2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Required to prevent the proliferation of the central cell by repressing unknown target genes before fertilization. Regulates the anteroposterior organization of the endosperm.

1 Publication

Caution

In cv. Landsberg erecta (AC P0DKJ7), the sequence differs from that shown due to an insertion in the genomic sequence that adds 60 residues after the Asn-564.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri136 – 157C2H2-typeSequence analysisAdd BLAST22

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polycomb group protein FERTILIZATION-INDEPENDENT SEED 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FIS21 Publication
Ordered Locus Names:At2g35670Imported
ORF Names:T20F21.14Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G35670

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000478361 – 755Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2Add BLAST755

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0DKJ8

PRoteomics IDEntifications database

More...
PRIDEi
P0DKJ8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
228922

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0DKJ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Weakly expressed. Expressed in late siliques.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed maternally and zygotically. Expressed in the central cell before fertilization, and in the endosperm after fertilization, then decreases before the time of endosperm cellularization but continues in the chalazal cyst.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P0DKJ8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ZNT9, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probably indirectly associated with FIE and/or MEA. In plants, PcG complexes are probably composed of a member of the EZ family (CLF or MEA), FIE, and a member of the VEFS family (FIS2, VRN2 or EMF2).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT2G35670.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0DKJ8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati245 – 266A-1By similarityAdd BLAST22
Repeati267 – 283B-1By similarityAdd BLAST17
Repeati284 – 306A-2By similarityAdd BLAST23
Repeati307 – 329A-3By similarityAdd BLAST23
Repeati330 – 351A-4By similarityAdd BLAST22
Repeati352 – 373A-5By similarityAdd BLAST22
Repeati374 – 390B-2By similarityAdd BLAST17
Repeati405 – 421B-3By similarityAdd BLAST17
Repeati422 – 443A-6By similarityAdd BLAST22
Repeati444 – 460B-4By similarityAdd BLAST17
Repeati461 – 483A-7By similarityAdd BLAST23
Repeati484 – 504A-8By similarityAdd BLAST21
Repeati505 – 521B-5By similarityAdd BLAST17
Repeati522 – 544A-9By similarityAdd BLAST23
Repeati545 – 565A-10By similarityAdd BLAST21
Repeati566 – 582B-6By similarityAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 28DisorderedSequence analysisAdd BLAST28
Regioni199 – 219DisorderedSequence analysisAdd BLAST21
Regioni234 – 263DisorderedSequence analysisAdd BLAST30
Regioni245 – 56510 X approximate repeat ABy similarityAdd BLAST321
Regioni267 – 5826 X approximate repeat BBy similarityAdd BLAST316
Regioni276 – 590DisorderedSequence analysisAdd BLAST315
Regioni590 – 725VEFS-boxSequence analysisAdd BLAST136

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi245 – 263Polar residuesSequence analysisAdd BLAST19
Compositional biasi300 – 331Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi345 – 363Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi364 – 382Polar residuesSequence analysisAdd BLAST19
Compositional biasi461 – 475Polar residuesSequence analysisAdd BLAST15
Compositional biasi485 – 515Polar residuesSequence analysisAdd BLAST31
Compositional biasi552 – 571Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri136 – 157C2H2-typeSequence analysisAdd BLAST22

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2350, Eukaryota

Database of Orthologous Groups

More...
OrthoDBi
516359at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0DKJ8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019135, Polycomb_protein_VEFS-Box

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09733, VEFS-Box, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0DKJ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARKSIRGKE VVMVSDDDDD DDDDVDDDKN IIKCVKPLTV YKNLETPTDS
60 70 80 90 100
DDNDDDDDDD VDVDENIIKY IKPVAVYKKL ETRSKNNPYF LRRSLKYIIQ
110 120 130 140 150
AKKKKKSNSG GKIRFNYRDV SNKMTLKAEV VENFSCPFCL IPCGGHEGLQ
160 170 180 190 200
LHLKSSHDAF KFEFYRAEKD HGPEVDVSVK SDTIKFGVLK DDVGNPQLSP
210 220 230 240 250
LTFCSKNRNQ RRQRDDSNNV KKLNVLLMEL DLDDLPRGTE NDSTHVNDDN
260 270 280 290 300
VSSPPRAHSS EKISDILTTT QLAIAESSEP KVPHVNDGNV SSPPRAHSSA
310 320 330 340 350
EKNESTHVND DDDVSSPPRA HSLEKNESTH VNEDNISSPP KAHSSKKNES
360 370 380 390 400
THMNDEDVSF PPRTRSSKET SDILTTTQPA IVEPSEPKVR RVSRRKQLYA
410 420 430 440 450
KRYKARETQP AIAESSEPKV LHVNDENVSS PPEAHSLEKA SDILTTTQPA
460 470 480 490 500
IAESSEPKVP HVNDENVSST PRAHSSKKNK STRKNVDNVP SPPKTRSSKK
510 520 530 540 550
TSDILTTTQP TIAESSEPKV RHVNDDNVSS TPRAHSSKKN KSTRKNDDNI
560 570 580 590 600
PSPPKTRSSK KTSNILATTQ PAKAEPSEPK VTRVSRRKEL HAERCEAKRL
610 620 630 640 650
ERLKGRQFYH SQTMQPITFE QVMSNEDSEN ETDDYALDIS ERLRLERLVG
660 670 680 690 700
VSKEEKRYMY LWNIFVRKQR VIADGHVPWA CEEFAKLHKE EMKNSSSFDW
710 720 730 740 750
WWRMFRIKLW NNGLICAKTF HKCTTILLSN SDEAGQFTSG SAANANNQQS

MEVDE
Length:755
Mass (Da):85,396
Last modified:January 20, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A0A75A3043F5BE4
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD15448 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC006068 Genomic DNA Translation: AAD15448.2 Sequence problems.
CP002685 Genomic DNA Translation: AEC09143.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E84771

NCBI Reference Sequences

More...
RefSeqi
NP_565815.2, NM_129122.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G35670.1; AT2G35670.1; AT2G35670

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
818136

Gramene; a comparative resource for plants

More...
Gramenei
AT2G35670.1; AT2G35670.1; AT2G35670

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G35670

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006068 Genomic DNA Translation: AAD15448.2 Sequence problems.
CP002685 Genomic DNA Translation: AEC09143.1
PIRiE84771
RefSeqiNP_565815.2, NM_129122.3

3D structure databases

SMRiP0DKJ8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G35670.1

PTM databases

iPTMnetiP0DKJ8

Proteomic databases

PaxDbiP0DKJ8
PRIDEiP0DKJ8
ProteomicsDBi228922

Genome annotation databases

EnsemblPlantsiAT2G35670.1; AT2G35670.1; AT2G35670
GeneIDi818136
GrameneiAT2G35670.1; AT2G35670.1; AT2G35670
KEGGiath:AT2G35670

Organism-specific databases

AraportiAT2G35670

Phylogenomic databases

eggNOGiKOG2350, Eukaryota
OrthoDBi516359at2759
PhylomeDBiP0DKJ8

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0DKJ8

Gene expression databases

ExpressionAtlasiP0DKJ8, baseline and differential
GenevisibleiQ9ZNT9, AT

Family and domain databases

InterProiView protein in InterPro
IPR019135, Polycomb_protein_VEFS-Box
PfamiView protein in Pfam
PF09733, VEFS-Box, 1 hit
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFIS2C_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0DKJ8
Secondary accession number(s): Q0QMM9, Q9ZNT9, Q9ZQP0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2016
Last sequence update: January 20, 2016
Last modified: September 29, 2021
This is version 33 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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