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Entry version 47 (12 Aug 2020)
Sequence version 1 (26 Nov 2014)
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Protein

Disease resistance protein RRS1

Gene

RRS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Acts also as a disease resistance protein involved in resistance to fungal and bacterial pathogens, including R.solanacearum, P.syringae pv. tomato and C.higginsianum. Heterodimerization with RPS4 is required to form a functional complex to recognize AvrRps4 and PopP2 (PubMed:24744375). Contributes to temperature-conditioned RPS4 auto-immunity (PubMed:24146667).Curated5 Publications

Miscellaneous

Ecotypes susceptible to C.higginsianum or R.solanacearum, such as cv. Columbia, contain a protein with a premature stop codon, while the longer allele found in cv. Nd-1, cv. Wassilewskija or cv. RLD confers resistance.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi179 – 186ATPSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1202 – 1270WRKYPROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processPlant defense, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Disease resistance protein RRS11 Publication
Alternative name(s):
Disease resistance protein RCH21 Publication
Disease resistance protein SLH1
Probable WRKY transcription factor 52
Protein RPS4-homolog1 Publication
Protein SENSITIVE TO LOW HUMIDITY 1
Resistance to Colletotrichum higginsianum 2 protein1 Publication
Resistance to Ralstonia solanacearum 1 protein1 Publication
WRKY DNA-binding protein 52
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RRS11 Publication
Synonyms:RCH21 Publication, RRS1-S1 Publication, RSH41 Publication, SLH1, WRKY52
Ordered Locus Names:At5g45260/At5g45270
ORF Names:K9E15.2/K9E15.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G45260

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi25S → A: No effect on TIR domain homodimerization. Loss of TIR domain heterodimerization; when associated with A-33 in RPS4. 1 Publication1
Mutagenesisi26H → A: No effect on TIR domain homodimerization. Loss of TIR domain heterodimerization with RPS4. 1 Publication1
Mutagenesisi185K → A: No effect on pathogen effectors triggered cell death. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001336931 – 1288Disease resistance protein RRS1Add BLAST1288

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0DKH5

PRoteomics IDEntifications database

More...
PRIDEi
P0DKH5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
246478 [P0DKH5-1]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P0DKH5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P0DKH5, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PopP2, a R.solanacearum type III effector (PubMed:12788974).

Interacts with RPS4 (PubMed:24744375).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
19811, 2 interactors

Database of interacting proteins

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DIPi
DIP-61676N

Protein interaction database and analysis system

More...
IntActi
P0DKH5, 4 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT5G45260.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11288
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0DKH5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 146TIRPROSITE-ProRule annotationAdd BLAST142
Domaini170 – 421NB-ARCSequence analysisAdd BLAST252
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati498 – 522LRR 1Sequence analysisAdd BLAST25
Repeati535 – 553LRR 2Sequence analysisAdd BLAST19
Repeati554 – 575LRR 3Sequence analysisAdd BLAST22
Repeati577 – 598LRR 4Sequence analysisAdd BLAST22
Repeati621 – 646LRR 5Sequence analysisAdd BLAST26
Repeati665 – 688LRR 6Sequence analysisAdd BLAST24
Repeati697 – 720LRR 7Sequence analysisAdd BLAST24
Repeati740 – 764LRR 8Sequence analysisAdd BLAST25
Repeati766 – 791LRR 9Sequence analysisAdd BLAST26
Repeati792 – 807LRR 10Sequence analysisAdd BLAST16
Repeati808 – 829LRR 11Sequence analysisAdd BLAST22
Repeati830 – 852LRR 12Sequence analysisAdd BLAST23

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 26Important for interaction with RPS41 Publication2

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi986 – 1003Nuclear localization signalPROSITE-ProRule annotationAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi463 – 466Poly-ArgSequence analysis4
Compositional biasi1186 – 1190Poly-LysSequence analysis5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TIR does not cause cell death, but can suppress RPS4 TIR domain-induced cell death (PubMed:24744375). The TIR domain is involved in homo- and heterodimerization, but other domains also contribute to the interaction (PubMed:24744375).1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K16225

Identification of Orthologs from Complete Genome Data

More...
OMAi
KHIPREY

Database of Orthologous Groups

More...
OrthoDBi
73809at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0DKH5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.25.80, 1 hit
3.40.50.10140, 1 hit
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011713, Leu-rich_rpt_3
IPR032675, LRR_dom_sf
IPR002182, NB-ARC
IPR027417, P-loop_NTPase
IPR035897, Toll_tir_struct_dom_sf
IPR036390, WH_DNA-bd_sf
IPR003657, WRKY_dom
IPR036576, WRKY_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07725, LRR_3, 1 hit
PF00931, NB-ARC, 1 hit
PF03106, WRKY, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00774, WRKY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF118290, SSF118290, 1 hit
SSF46785, SSF46785, 1 hit
SSF52200, SSF52200, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50104, TIR, 1 hit
PS50811, WRKY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P0DKH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTNCEKDEEF VCISCVEEVR YSFVSHLSEA LRRKGINNVV VDVDIDDLLF
60 70 80 90 100
KESQAKIEKA GVSVMVLPGN CDPSEVWLDK FAKVLECQRN NKDQAVVSVL
110 120 130 140 150
YGDSLLRDQW LSELDFRGLS RIHQSRKECS DSILVEEIVR DVYETHFYVG
160 170 180 190 200
RIGIYSKLLE IENMVNKQPI GIRCVGIWGM PGIGKTTLAK AVFDQMSSAF
210 220 230 240 250
DASCFIEDYD KSIHEKGLYC LLEEQLLPGN DATIMKLSSL RDRLNSKRVL
260 270 280 290 300
VVLDDVRNAL VGESFLEGFD WLGPGSLIII TSRDKQVFCL CGINQIYEVQ
310 320 330 340 350
GLNEKEARQL FLLSASIKED MGEQNLQELS VRVINYANGN PLAISVYGRE
360 370 380 390 400
LKGKKKLSEM ETAFLKLKRR PPFKIVDAFK STYDTLSDNE KNIFLDIACF
410 420 430 440 450
FQGENVNYVI QLLEGCGFFP HVEIDVLVDK CLVTISENRV WLHKLTQDIG
460 470 480 490 500
REIINGETVQ IERRRRLWEP WSIKYLLEYN EHKANGEPKT TFKRAQGSEE
510 520 530 540 550
IEGLFLDTSN LRFDLQPSAF KNMLNLRLLK IYCSNPEVHP VINFPTGSLH
560 570 580 590 600
SLPNELRLLH WENYPLKSLP QNFDPRHLVE INMPYSQLQK LWGGTKNLEM
610 620 630 640 650
LRTIRLCHSH HLVDIDDLLK AENLEVIDLQ GCTRLQNFPA AGRLLRLRVV
660 670 680 690 700
NLSGCIKIKS VLEIPPNIEK LHLQGTGILA LPVSTVKPNH RELVNFLTEI
710 720 730 740 750
PGLSEELERL TSLLESNSSC QDLGKLICLE LKDCSCLQSL PNMANLDLNV
760 770 780 790 800
LDLSGCSSLN SIQGFPRFLK QLYLGGTAIR EVPQLPQSLE ILNAHGSCLR
810 820 830 840 850
SLPNMANLEF LKVLDLSGCS ELETIQGFPR NLKELYFAGT TLREVPQLPL
860 870 880 890 900
SLEVLNAHGS DSEKLPMHYK FNNFFDLSQQ VVNDFLLKTL TYVKHIPRGY
910 920 930 940 950
TQELINKAPT FSFSAPSHTN QNATFDLQSG SSVMTRLNHS WRNTLVGFGM
960 970 980 990 1000
LVEVAFPEDY CDATDVGISC VCRWSNKEGR SCRIERKFHC WAPWQVVPKV
1010 1020 1030 1040 1050
RKDHTFVFSD VNMRPSTGEG NDPDIWAGLV VFEFFPINQQ TKCLNDRFTV
1060 1070 1080 1090 1100
RRCGVRVINV ATGNTSLENI ALVLSLDPVE VSGYEVLRVS YDDLQEMDKV
1110 1120 1130 1140 1150
LFLYIASLFN DEDVDFVAPL IAGIDLDVSS GLKVLADVSL ISVSSNGEIV
1160 1170 1180 1190 1200
MHSLQRQMGK EILHGQSMLL SDCESSMTEN LSDVPKKKKK HSESRVKKVV
1210 1220 1230 1240 1250
SIPAIDEGDL WTWRKYGQKD ILGSRFPRGY YRCAYKFTHG CKATKQVQRS
1260 1270 1280
ETDSNMLAIT YLSEHNHPRP TKRKALADST RSTSSSIC
Length:1,288
Mass (Da):145,879
Last modified:November 26, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB364DE7CE4DB6706
GO
Isoform 2 (identifier: P0DKH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1188-1288: Missing.

Note: May be due to intron retention.Curated
Show »
Length:1,187
Mass (Da):134,276
Checksum:i7EF6A2240C692B11
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB10247 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes At5g45260 and At5g45270.Curated
The sequence BAB10248 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes At5g45260 and At5g45270.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti395L → S in BAC41834 (PubMed:11910074).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0156961188 – 1288Missing in isoform 2. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AX103684 Genomic DNA No translation available.
AB020744 Genomic DNA Translation: BAB10247.1 Sequence problems.
AB020744 Genomic DNA Translation: BAB10248.1 Sequence problems.
CP002688 Genomic DNA Translation: AED95222.1
CP002688 Genomic DNA Translation: AED95223.1
CP002688 Genomic DNA Translation: ANM68859.1
AK117156 mRNA Translation: BAC41834.1
AK226456 mRNA Translation: BAE98598.1

NCBI Reference Sequences

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RefSeqi
NP_001078715.1, NM_001085246.2 [P0DKH5-2]
NP_001318742.1, NM_001344604.1 [P0DKH5-2]
NP_199339.2, NM_123894.4 [P0DKH5-1]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G45260.1; AT5G45260.1; AT5G45260 [P0DKH5-1]
AT5G45260.2; AT5G45260.2; AT5G45260 [P0DKH5-2]
AT5G45260.3; AT5G45260.3; AT5G45260 [P0DKH5-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
834562

Gramene; a comparative resource for plants

More...
Gramenei
AT5G45260.1; AT5G45260.1; AT5G45260 [P0DKH5-1]
AT5G45260.2; AT5G45260.2; AT5G45260 [P0DKH5-2]
AT5G45260.3; AT5G45260.3; AT5G45260 [P0DKH5-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT5G45260

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIB-LRRS

Functional and comparative genomics of disease resistance gene homologs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AX103684 Genomic DNA No translation available.
AB020744 Genomic DNA Translation: BAB10247.1 Sequence problems.
AB020744 Genomic DNA Translation: BAB10248.1 Sequence problems.
CP002688 Genomic DNA Translation: AED95222.1
CP002688 Genomic DNA Translation: AED95223.1
CP002688 Genomic DNA Translation: ANM68859.1
AK117156 mRNA Translation: BAC41834.1
AK226456 mRNA Translation: BAE98598.1
RefSeqiNP_001078715.1, NM_001085246.2 [P0DKH5-2]
NP_001318742.1, NM_001344604.1 [P0DKH5-2]
NP_199339.2, NM_123894.4 [P0DKH5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C6SX-ray1.75A7-153[»]
4C6TX-ray2.65A/C6-153[»]
SMRiP0DKH5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi19811, 2 interactors
DIPiDIP-61676N
IntActiP0DKH5, 4 interactors
STRINGi3702.AT5G45260.1

Proteomic databases

PaxDbiP0DKH5
PRIDEiP0DKH5
ProteomicsDBi246478 [P0DKH5-1]

Genome annotation databases

EnsemblPlantsiAT5G45260.1; AT5G45260.1; AT5G45260 [P0DKH5-1]
AT5G45260.2; AT5G45260.2; AT5G45260 [P0DKH5-2]
AT5G45260.3; AT5G45260.3; AT5G45260 [P0DKH5-2]
GeneIDi834562
GrameneiAT5G45260.1; AT5G45260.1; AT5G45260 [P0DKH5-1]
AT5G45260.2; AT5G45260.2; AT5G45260 [P0DKH5-2]
AT5G45260.3; AT5G45260.3; AT5G45260 [P0DKH5-2]
KEGGiath:AT5G45260

Organism-specific databases

AraportiAT5G45260

Phylogenomic databases

KOiK16225
OMAiKHIPREY
OrthoDBi73809at2759
PhylomeDBiP0DKH5

Miscellaneous databases

Protein Ontology

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PROi
PR:P0DKH5

Gene expression databases

ExpressionAtlasiP0DKH5, baseline and differential
GenevisibleiP0DKH5, AT

Family and domain databases

Gene3Di2.20.25.80, 1 hit
3.40.50.10140, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR011713, Leu-rich_rpt_3
IPR032675, LRR_dom_sf
IPR002182, NB-ARC
IPR027417, P-loop_NTPase
IPR035897, Toll_tir_struct_dom_sf
IPR036390, WH_DNA-bd_sf
IPR003657, WRKY_dom
IPR036576, WRKY_dom_sf
PfamiView protein in Pfam
PF07725, LRR_3, 1 hit
PF00931, NB-ARC, 1 hit
PF03106, WRKY, 1 hit
SMARTiView protein in SMART
SM00774, WRKY, 1 hit
SUPFAMiSSF118290, SSF118290, 1 hit
SSF46785, SSF46785, 1 hit
SSF52200, SSF52200, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50104, TIR, 1 hit
PS50811, WRKY, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWRK52_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0DKH5
Secondary accession number(s): Q0WWA0
, Q689Y9, Q8GZ83, Q9FH83, Q9FH84
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 26, 2014
Last sequence update: November 26, 2014
Last modified: August 12, 2020
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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