UniProtKB - P0DKB6 (MPC1L_HUMAN)
Protein
Mitochondrial pyruvate carrier 1-like protein
Gene
MPC1L
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- pyruvate transmembrane transporter activity Source: GO_Central
GO - Biological processi
- mitochondrial pyruvate transmembrane transport Source: GO_Central
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | P0DKB6 |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial pyruvate carrier 1-like protein |
Gene namesi | Name:MPC1L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:44205, MPC1L |
neXtProti | NX_P0DKB6 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Mitochondrion
- integral component of mitochondrial inner membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 20 – 42 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 52 – 74 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Miscellaneous databases
Pharosi | P0DKB6, Tdark |
Polymorphism and mutation databases
BioMutai | MPC1L |
DMDMi | 408387577 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000419605 | 1 – 136 | Mitochondrial pyruvate carrier 1-like proteinAdd BLAST | 136 |
Proteomic databases
jPOSTi | P0DKB6 |
MassIVEi | P0DKB6 |
PeptideAtlasi | P0DKB6 |
PRIDEi | P0DKB6 |
PTM databases
iPTMneti | P0DKB6 |
PhosphoSitePlusi | P0DKB6 |
Family & Domainsi
Sequence similaritiesi
Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00940000163590 |
InParanoidi | P0DKB6 |
OMAi | MAFMRFA |
OrthoDBi | 1584711at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR005336, MPC |
Pfami | View protein in Pfam PF03650, MPC, 1 hit |
i Sequence
Sequence statusi: Complete.
P0DKB6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARMAVLWRK MRDNFQSKEF REYVSSTHFW GPAFSWGLPL AAFKDMKASP
60 70 80 90 100
EIISGRMTTA LILYSAIFMR FAYRVQPRNL LLMACHCTNV MAQSVQASRY
110 120 130
LLYYYGGGGA EAKARDPPAT AAAATSPGSQ PPKQAS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092473 Genomic DNA No translation available. DB337430 mRNA No translation available. |
CCDSi | CCDS83466.1 |
RefSeqi | NP_001182451.1, NM_001195522.2 |
Genome annotation databases
Ensembli | ENST00000423387; ENSP00000489748; ENSG00000238205 |
GeneIDi | 347411 |
KEGGi | hsa:347411 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092473 Genomic DNA No translation available. DB337430 mRNA No translation available. |
CCDSi | CCDS83466.1 |
RefSeqi | NP_001182451.1, NM_001195522.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PTM databases
iPTMneti | P0DKB6 |
PhosphoSitePlusi | P0DKB6 |
Polymorphism and mutation databases
BioMutai | MPC1L |
DMDMi | 408387577 |
Proteomic databases
jPOSTi | P0DKB6 |
MassIVEi | P0DKB6 |
PeptideAtlasi | P0DKB6 |
PRIDEi | P0DKB6 |
Genome annotation databases
Ensembli | ENST00000423387; ENSP00000489748; ENSG00000238205 |
GeneIDi | 347411 |
KEGGi | hsa:347411 |
Organism-specific databases
CTDi | 347411 |
GeneCardsi | MPC1L |
HGNCi | HGNC:44205, MPC1L |
HPAi | ENSG00000238205, Tissue enriched (testis) |
neXtProti | NX_P0DKB6 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000163590 |
InParanoidi | P0DKB6 |
OMAi | MAFMRFA |
OrthoDBi | 1584711at2759 |
Enzyme and pathway databases
PathwayCommonsi | P0DKB6 |
Miscellaneous databases
BioGRID-ORCSi | 347411, 0 hits in 64 CRISPR screens |
GenomeRNAii | 347411 |
Pharosi | P0DKB6, Tdark |
PROi | PR:P0DKB6 |
RNActi | P0DKB6, protein |
Family and domain databases
InterProi | View protein in InterPro IPR005336, MPC |
Pfami | View protein in Pfam PF03650, MPC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MPC1L_HUMAN | |
Accessioni | P0DKB6Primary (citable) accession number: P0DKB6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | December 2, 2020 | |
This is version 40 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM