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UniProtKB - P0DJQ3 (PAH_STRCL)
Protein
Proclavaminate amidinohydrolase
Gene
pah
Organism
Streptomyces clavuligerus
Status
Functioni
Catalytic activityi
- EC:3.5.3.221 Publication
Cofactori
Mn2+PROSITE-ProRule annotation1 PublicationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation1 Publication
: clavulanate biosynthesis Pathwayi
This protein is involved in step 4 of the subpathway that synthesizes clavulanate from D-glyceraldehyde 3-phosphate and L-arginine.1 Publication This subpathway is part of the pathway clavulanate biosynthesis, which is itself part of Antibiotic biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes clavulanate from D-glyceraldehyde 3-phosphate and L-arginine, the pathway clavulanate biosynthesis and in Antibiotic biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 121 | Manganese 1Combined sources1 Publication | 1 | |
Metal bindingi | 144 | Manganese 1Combined sources1 Publication | 1 | |
Metal bindingi | 144 | Manganese 2Combined sources1 Publication | 1 | |
Metal bindingi | 146 | Manganese 2Combined sources1 Publication | 1 | |
Metal bindingi | 148 | Manganese 1Combined sources1 Publication | 1 | |
Metal bindingi | 235 | Manganese 1Combined sources1 Publication | 1 | |
Metal bindingi | 235 | Manganese 2Combined sources1 Publication | 1 | |
Metal bindingi | 237 | Manganese 2Combined sources1 Publication | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- proclavaminate amidinohydrolase activity Source: UniProtKB-EC
GO - Biological processi
- clavulanic acid biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Hydrolase |
Ligand | Manganese, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.5.3.22, 5988 |
UniPathwayi | UPA00112;UER00245 |
Names & Taxonomyi
Protein namesi | Recommended name: Proclavaminate amidinohydrolase (EC:3.5.3.221 Publication)Alternative name(s): Proclavaminic acid amidino hydrolase |
Gene namesi | Name:pah |
Organismi | Streptomyces clavuligerus |
Taxonomic identifieri | 1901 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173746 | 1 – 313 | Proclavaminate amidinohydrolaseAdd BLAST | 313 |
Interactioni
Subunit structurei
Homohexamer.
1 PublicationProtein-protein interaction databases
STRINGi | 443255.SCLAV_4195 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P0DJQ3 |
SMRi | P0DJQ3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the arginase family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | COG0010, Bacteria |
OMAi | PITPFDA |
OrthoDBi | 1598732at2 |
Family and domain databases
InterProi | View protein in InterPro IPR005925, Agmatinase-rel IPR006035, Ureohydrolase IPR023696, Ureohydrolase_dom_sf IPR020855, Ureohydrolase_Mn_BS |
PANTHERi | PTHR11358, PTHR11358, 1 hit |
Pfami | View protein in Pfam PF00491, Arginase, 1 hit |
PIRSFi | PIRSF036979, Arginase, 1 hit |
PRINTSi | PR00116, ARGINASE |
SUPFAMi | SSF52768, SSF52768, 1 hit |
TIGRFAMsi | TIGR01230, agmatinase, 1 hit |
PROSITEi | View protein in PROSITE PS01053, ARGINASE_1, 1 hit PS51409, ARGINASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P0DJQ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERIDSHVSP RYAQIPTFMR LPHDPQPRGY DVVVIGAPYD GGTSYRPGAR
60 70 80 90 100
FGPQAIRSES GLIHGVGIDR GPGTFDLINC VDAGDINLTP FDMNIAIDTA
110 120 130 140 150
QSHLSGLLKA NAAFLMIGGD HSLTVAALRA VAEQHGPLAV VHLDAHSDTN
160 170 180 190 200
PAFYGGRYHH GTPFRHGIDE KLIDPAAMVQ IGIRGHNPKP DSLDYARGHG
210 220 230 240 250
VRVVTADEFG ELGVGGTADL IREKVGQRPV YVSVDIDVVD PAFAPGTGTP
260 270 280 290 300
APGGLLSREV LALLRCVGDL KPVGFDVMEV SPLYDHGGIT SILATEIGAE
310
LLYQYARAHR TQL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X84101 Genomic DNA Translation: CAA58904.1 U87786 Genomic DNA Translation: AAA62451.1 |
PIRi | S57669 |
RefSeqi | WP_003952511.1, NZ_CP032052.1 |
Genome annotation databases
GeneIDi | 61469725 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X84101 Genomic DNA Translation: CAA58904.1 U87786 Genomic DNA Translation: AAA62451.1 |
PIRi | S57669 |
RefSeqi | WP_003952511.1, NZ_CP032052.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GQ6 | X-ray | 1.75 | A/B/C | 1-313 | [»] | |
1GQ7 | X-ray | 2.45 | A/B/C/D/E/F | 1-313 | [»] | |
AlphaFoldDBi | P0DJQ3 | |||||
SMRi | P0DJQ3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 443255.SCLAV_4195 |
Genome annotation databases
GeneIDi | 61469725 |
Phylogenomic databases
eggNOGi | COG0010, Bacteria |
OMAi | PITPFDA |
OrthoDBi | 1598732at2 |
Enzyme and pathway databases
UniPathwayi | UPA00112;UER00245 |
BRENDAi | 3.5.3.22, 5988 |
Family and domain databases
InterProi | View protein in InterPro IPR005925, Agmatinase-rel IPR006035, Ureohydrolase IPR023696, Ureohydrolase_dom_sf IPR020855, Ureohydrolase_Mn_BS |
PANTHERi | PTHR11358, PTHR11358, 1 hit |
Pfami | View protein in Pfam PF00491, Arginase, 1 hit |
PIRSFi | PIRSF036979, Arginase, 1 hit |
PRINTSi | PR00116, ARGINASE |
SUPFAMi | SSF52768, SSF52768, 1 hit |
TIGRFAMsi | TIGR01230, agmatinase, 1 hit |
PROSITEi | View protein in PROSITE PS01053, ARGINASE_1, 1 hit PS51409, ARGINASE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PAH_STRCL | |
Accessioni | P0DJQ3Primary (citable) accession number: P0DJQ3 Secondary accession number(s): P0DJQ4, P37819, P72400 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2012 |
Last sequence update: | September 5, 2012 | |
Last modified: | May 25, 2022 | |
This is version 37 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families