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UniProtKB - P0DJM7 (PA2B_PROTO)
Protein
Basic phospholipase A2 Pto-N6
Gene
N/A
Organism
Protobothrops tokarensis (Tokara habu) (Trimeresurus tokarensis)
Status
Functioni
Snake venom phospholipase A2 (PLA2) that displays edema-inducing activities, as well as presynaptic neurotoxicity and myotoxicity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity).
By similarityCatalytic activityi
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+EC:3.1.1.4
Cofactori
Ca2+By similarityNote: Binds 1 Ca2+ ion.By similarity
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- phospholipase A2 activity Source: UniProtKB-EC
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- lipid catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Myotoxin, Neurotoxin, Presynaptic neurotoxin, Toxin |
Biological process | Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Basic phospholipase A2 Pto-N6 (EC:3.1.1.4)Short name: svPLA2 Alternative name(s): Phosphatidylcholine 2-acylhydrolase |
Organismi | Protobothrops tokarensis (Tokara habu) (Trimeresurus tokarensis) |
Taxonomic identifieri | 61225 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Crotalinae › Protobothrops |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000418562 | 1 – ›23 | Basic phospholipase A2 Pto-N6Add BLAST | ›23 |
Post-translational modificationi
Contains 7 disulfide bonds.By similarity
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.
Structurei
Family & Domainsi
Sequence similaritiesi
i Sequence
Sequence statusi: Fragment.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 23 | 1 |
Mass spectrometryi
Molecular mass is 14033 Da. Determined by ESI. 1 Publication
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
MobiDBi | Search... |
Entry informationi
Entry namei | PA2B_PROTO | |
Accessioni | P0DJM7Primary (citable) accession number: P0DJM7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2012 |
Last sequence update: | September 5, 2012 | |
Last modified: | February 23, 2022 | |
This is version 16 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families