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Entry version 48 (08 May 2019)
Sequence version 1 (05 Sep 2012)
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Protein

Diphtheria toxin repressor

Gene

dtxR

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess.

Miscellaneous

The N-terminal region may be involved in iron binding and may associate with the tox operator. Binding of dtxR to tox operator requires a divalent metal ion such as cobalt, ferric, manganese, and nickel ions whereas zinc ions show weak activation.
The dtxR gene was functional in the non-toxygenic strains CD95/211-, CD95/305- and CD95/407- isolated in the United Kingdom. These findings demonstrate that, if lysogenised by a bacteriophage, non-toxygenic strains could produce toxin and therefore represent a potential reservoir for toxygenic C.diphtheriae.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandIron

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
CDIP257309:G1GT3-1437-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Diphtheria toxin repressor
Alternative name(s):
Iron-dependent diphtheria tox regulatory element
Tox regulatory factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dtxR
Ordered Locus Names:DIP1414
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri257309 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002198 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002011061 – 226Diphtheria toxin repressorAdd BLAST226

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P0DJL7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

Molecular INTeraction database

More...
MINTi
P0DJL7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1226
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0DJL7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 65HTH dtxR-typePROSITE-ProRule annotationAdd BLAST62

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DtxR/MntR family.Curated

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K03709

Identification of Orthologs from Complete Genome Data

More...
OMAi
EHVMGDE

Database of Orthologous Groups

More...
OrthoDBi
2047422at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
1.10.60.10, 1 hit
2.30.30.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040767 DtxR_SH3
IPR007167 Fe-transptr_FeoA
IPR001367 Fe_dep_repressor
IPR036421 Fe_dep_repressor_sf
IPR038157 FeoA_core_dom
IPR022687 HTH_DTXR
IPR022689 Iron_dep_repressor
IPR008988 Transcriptional_repressor_C
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18357 DtxR, 1 hit
PF02742 Fe_dep_repr_C, 1 hit
PF01325 Fe_dep_repress, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00899 FeoA, 1 hit
SM00529 HTH_DTXR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF47979 SSF47979, 1 hit
SSF50037 SSF50037, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50944 HTH_DTXR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0DJL7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDLVDTTEM YLRTIYELEE EGVTPLRARI AERLEQSGPT VSQTVARMER
60 70 80 90 100
DGLVVVASDR SLQMTPTGRT LATAVMRKHR LAERLLTDII GLDINKVHDE
110 120 130 140 150
ACRWEHVMSD EVERRLVKVL KDVSRSPFGN PIPGLDELGV GNSDAAVPGT
160 170 180 190 200
RVIDAATSMP RKVRIVQINE IFQVETDQFT QLLDADIRVG SEVEIVDRDG
210 220
HITLSHNGKD VELIDDLAHT IRIEEL
Length:226
Mass (Da):25,344
Last modified:September 5, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA14F89FDB8719D5C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti47R → H in iron-insensitive tox constitutive mutant C7hm723. 1
Natural varianti141G → R in strain: CD95/211-. 1
Natural varianti147V → A in strain: C7(-), C7hm723(-), 1030(-), CD95/305-, CD95/211- and CD95/407-. 1
Natural varianti165I → V in strain: 1030(-). 1
Natural varianti174V → A in strain: 1030(-). 1
Natural varianti191S → T in strain: 1030(-). 1
Natural varianti199D → V in strain: CD95/407-. 1
Natural varianti201H → R in strain: CD95/305-. 1
Natural varianti205S → R in strain: 1030(-). 1
Natural varianti214I → L in strain: C7(-), C7hm723(-), CD95/305-, CD95/211- and CD95/407-. 1
Natural varianti214I → Y in strain: 1030(-). 1
Natural varianti218A → T in strain: 1030(-). 1
Natural varianti221I → M in strain: CD95/211-. 1
Natural varianti221I → T in strain: CD95/407-. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M34239 Genomic DNA Translation: AAA23296.1
M80336 Genomic DNA Translation: AAA23302.1
M80337 Genomic DNA Translation: AAA23301.1
AY741368 Genomic DNA Translation: AAU93781.1
AY741369 Genomic DNA Translation: AAU93782.1
AY741370 Genomic DNA Translation: AAU93783.1
BX248358 Genomic DNA Translation: CAE49945.1

Protein sequence database of the Protein Information Resource

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PIRi
A35968

NCBI Reference Sequences

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RefSeqi
WP_010935052.1, NC_002935.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAE49945; CAE49945; DIP1414

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cdi:DIP1414

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34239 Genomic DNA Translation: AAA23296.1
M80336 Genomic DNA Translation: AAA23302.1
M80337 Genomic DNA Translation: AAA23301.1
AY741368 Genomic DNA Translation: AAU93781.1
AY741369 Genomic DNA Translation: AAU93782.1
AY741370 Genomic DNA Translation: AAU93783.1
BX248358 Genomic DNA Translation: CAE49945.1
PIRiA35968
RefSeqiWP_010935052.1, NC_002935.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BI0X-ray2.30A1-226[»]
1BI1X-ray2.20A1-226[»]
1BI2X-ray2.30A/B1-226[»]
1BI3X-ray2.40A/B1-226[»]
1BYMNMR-A130-226[»]
1C0WX-ray3.20A/B/C/D2-226[»]
1DDNX-ray3.00A/B/C/D1-226[»]
1DPRX-ray3.00A/B1-226[»]
1F5TX-ray3.00A/B/C/D1-121[»]
1FWZX-ray2.30A1-226[»]
1G3SX-ray2.40A1-226[»]
1G3TX-ray2.35A/B1-226[»]
1G3WX-ray2.40A1-226[»]
1G3YX-ray2.80A1-226[»]
1P92X-ray2.10A1-226[»]
1QVPNMR-A148-226[»]
1QW1NMR-A110-226[»]
1XCVX-ray2.10A1-139[»]
2DTRX-ray1.90A1-226[»]
2QQ9X-ray1.71A1-226[»]
2QQAX-ray2.10A1-226[»]
2QQBX-ray1.92A1-226[»]
2TDXX-ray2.40A1-226[»]
3GLXX-ray1.85A1-226[»]
SMRiP0DJL7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiP0DJL7

Proteomic databases

PRIDEiP0DJL7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE49945; CAE49945; DIP1414
KEGGicdi:DIP1414

Phylogenomic databases

KOiK03709
OMAiEHVMGDE
OrthoDBi2047422at2

Enzyme and pathway databases

BioCyciCDIP257309:G1GT3-1437-MONOMER

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.10.60.10, 1 hit
2.30.30.90, 1 hit
InterProiView protein in InterPro
IPR040767 DtxR_SH3
IPR007167 Fe-transptr_FeoA
IPR001367 Fe_dep_repressor
IPR036421 Fe_dep_repressor_sf
IPR038157 FeoA_core_dom
IPR022687 HTH_DTXR
IPR022689 Iron_dep_repressor
IPR008988 Transcriptional_repressor_C
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF18357 DtxR, 1 hit
PF02742 Fe_dep_repr_C, 1 hit
PF01325 Fe_dep_repress, 1 hit
SMARTiView protein in SMART
SM00899 FeoA, 1 hit
SM00529 HTH_DTXR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47979 SSF47979, 1 hit
SSF50037 SSF50037, 1 hit
PROSITEiView protein in PROSITE
PS50944 HTH_DTXR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDTXR_CORDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0DJL7
Secondary accession number(s): P33120
, Q5XQ41, Q5XQ42, Q5XQ43
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: September 5, 2012
Last modified: May 8, 2019
This is version 48 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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