UniProtKB - P0DJK3 (BPPAE_BOTCO)
Protein
Bradykinin-potentiating peptide 10e
Gene
N/A
Organism
Bothrops cotiara (Cotiara) (Rhinocerophis cotiara)
Status
Functioni
This peptide evokes transient hypotension (-11 mmHg) similar to that evoked by 0,5 µg of bradykinin, when injected alone into rats. It has a high bradykinin-potentiating effect (113%), when 60 nmol of BPP-10e are coinjected with 0.5 µg of bradykinin into rats. It inhibits angiotensin converting enzyme (ACE) activity with a K(i)app of 16.21 µM.1 Publication
GO - Molecular functioni
- metalloendopeptidase inhibitor activity Source: UniProtKB-KW
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- regulation of blood pressure Source: UniProtKB-KW
Keywordsi
Molecular function | Hypotensive agent, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Bradykinin-potentiating peptide 10eShort name: BPP-10e |
Organismi | Bothrops cotiara (Cotiara) (Rhinocerophis cotiara) |
Taxonomic identifieri | 8727 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Crotalinae › Bothrops |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000421904 | 1 – 10 | Bradykinin-potentiating peptide 10e | 10 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | Pyrrolidone carboxylic acid1 Publication | 1 |
Keywords - PTMi
Pyrrolidone carboxylic acidExpressioni
Tissue specificityi
Expressed by the venom gland.
Family & Domainsi
Sequence similaritiesi
Belongs to the bradykinin-potentiating peptide family.Curated
i Sequence
Sequence statusi: Complete.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence uncertaintyi | 7 | K or Q | 1 |
Mass spectrometryi
Cross-referencesi
3D structure databases
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
ProtoNeti | Search... |
Entry informationi
Entry namei | BPPAE_BOTCO | |
Accessioni | P0DJK3Primary (citable) accession number: P0DJK3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2013 |
Last sequence update: | April 3, 2013 | |
Last modified: | November 22, 2017 | |
This is version 10 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families