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Protein

SLIT-ROBO Rho GTPase-activating protein 2C

Gene

SRGAP2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and memory.1 Publication

Miscellaneous

This is one of the 3 duplications of the ancestral gene SRGAP2 which has undergone human-specific segmental gene duplications. The appearance of SRGAP2C in the human genome is estimated to 2,4 million years and corresponds to the beginning of neocortex expansion in human evolution. SRGAP2C may have, therefore, played an important role in this process. 2 other copies of SRGAP2, SRGAP2B and SRGAP2D, were identified in some individuals but it is not clear if they produce a functional protein (PubMed:22559944). SRGAP2C is the only copy to be fixed at a diploid state in the genome and to exhibit strong mRNA expression. A cDNA specific for that gene was used in the functional study (PubMed:22559944).1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • Rac GTPase binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processNeurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
SLIT-ROBO Rho GTPase-activating protein 2C
Alternative name(s):
SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1
Gene namesi
Name:SRGAP2C
Synonyms:SRGAP2P1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000171943.11
HGNCiHGNC:30584 SRGAP2C
MIMi614704 gene
neXtProtiNX_P0DJJ0

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171943

Polymorphism and mutation databases

DMDMi395455176

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004181931 – 459SLIT-ROBO Rho GTPase-activating protein 2CAdd BLAST459

Proteomic databases

EPDiP0DJJ0
MaxQBiP0DJJ0
PeptideAtlasiP0DJJ0
PRIDEiP0DJJ0
ProteomicsDBi52551

PTM databases

iPTMnetiP0DJJ0
PhosphoSitePlusiP0DJJ0

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in cerebellum. Probably expressed in fetal and adult neurons (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000171943 Expressed in 92 organ(s), highest expression level in cerebellum
ExpressionAtlasiP0DJJ0 baseline and differential
GenevisibleiP0DJJ0 HS

Interactioni

Subunit structurei

Homodimer. Interacts with SRGAP2; formation of the heterodimer alters SRGAP2 function.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi575800, 1 interactor
IntActiP0DJJ0, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP0DJJ0
SMRiP0DJJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 325F-BARPROSITE-ProRule annotationAdd BLAST304

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili363 – 401Sequence analysisAdd BLAST39

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3565 Eukaryota
ENOG410XS44 LUCA
GeneTreeiENSGT00760000118863
InParanoidiP0DJJ0
OMAiKHEGLME

Family and domain databases

InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR030252 srGAP2
PANTHERiPTHR14166:SF6 PTHR14166:SF6, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P0DJJ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSPAKFKKD KEIIAEYDTQ VKEIRAQLTE QMKCLDQQCE LRVQLLQDLQ
60 70 80 90 100
DFFRKKAEIE MDYSRNLEKL AEHFLAKTRS TKDQQFKKDQ NVLSPVNCWN
110 120 130 140 150
LLLNQVKWES RDHTTLSDIY LNNIIPRFVQ VSEDSGRLFK KSKEVGQQLQ
160 170 180 190 200
DDLMKVLNEL YSVMKTYHMY NADSISAQSK LKEAEKQEEK QIGKSVKQED
210 220 230 240 250
RQTPCSPDST ANVRIEEKHV RRSSVKKIEK MKEKHQAKYT ENKLKAIKAQ
260 270 280 290 300
NEYLLALEAT NASVFKYYIH DLSDLIDQCC DLGYHASLNR ALRTFLSAEL
310 320 330 340 350
NLEQSKHEGL DAIENAVENL DATSDKQRLM EMYNNVFCPP MKFEFQPHMG
360 370 380 390 400
DMASQLCAQQ PVQSELVQRC QQLQSRLSTL KIENEEVKKT MEATLQTIQD
410 420 430 440 450
IVTVEDFDVS DCFQYSNSME SVKSTVSETF MSKPSIAKRR ANQQETEQFY

FTVRECYGF
Length:459
Mass (Da):53,484
Last modified:July 11, 2012 - v1
Checksum:i3FBAC28FE3C43297
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0L1A0A087X0L1_HUMAN
SLIT-ROBO Rho GTPase-activating pro...
SRGAP2C
305Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti278Missing in BC112927 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC243994 Genomic DNA No translation available.
AC244021 Genomic DNA No translation available.
AC244453 Genomic DNA No translation available.
BC112927 mRNA No translation available.
CCDSiCCDS81364.1
RefSeqiNP_001316913.1, NM_001329984.1
UniGeneiHs.497575
Hs.523529
Hs.698027

Genome annotation databases

EnsembliENST00000367123; ENSP00000478290; ENSG00000171943
GeneIDi653464
KEGGihsa:653464
UCSCiuc057jxs.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC243994 Genomic DNA No translation available.
AC244021 Genomic DNA No translation available.
AC244453 Genomic DNA No translation available.
BC112927 mRNA No translation available.
CCDSiCCDS81364.1
RefSeqiNP_001316913.1, NM_001329984.1
UniGeneiHs.497575
Hs.523529
Hs.698027

3D structure databases

ProteinModelPortaliP0DJJ0
SMRiP0DJJ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi575800, 1 interactor
IntActiP0DJJ0, 1 interactor

PTM databases

iPTMnetiP0DJJ0
PhosphoSitePlusiP0DJJ0

Polymorphism and mutation databases

DMDMi395455176

Proteomic databases

EPDiP0DJJ0
MaxQBiP0DJJ0
PeptideAtlasiP0DJJ0
PRIDEiP0DJJ0
ProteomicsDBi52551

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367123; ENSP00000478290; ENSG00000171943
GeneIDi653464
KEGGihsa:653464
UCSCiuc057jxs.1 human

Organism-specific databases

CTDi653464
EuPathDBiHostDB:ENSG00000171943.11
GeneCardsiSRGAP2C
HGNCiHGNC:30584 SRGAP2C
MIMi614704 gene
neXtProtiNX_P0DJJ0
OpenTargetsiENSG00000171943
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3565 Eukaryota
ENOG410XS44 LUCA
GeneTreeiENSGT00760000118863
InParanoidiP0DJJ0
OMAiKHEGLME

Miscellaneous databases

ChiTaRSiSRGAP2C human
GeneWikiiSRGAP2C
GenomeRNAii653464
PROiPR:P0DJJ0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171943 Expressed in 92 organ(s), highest expression level in cerebellum
ExpressionAtlasiP0DJJ0 baseline and differential
GenevisibleiP0DJJ0 HS

Family and domain databases

InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR030252 srGAP2
PANTHERiPTHR14166:SF6 PTHR14166:SF6, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSRG2C_HUMAN
AccessioniPrimary (citable) accession number: P0DJJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: July 11, 2012
Last modified: November 7, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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