SAA1

Functionⁱ

Major acute phase protein.

GO - Molecular functionⁱ

chemoattractant activity Source: GO_Central
G-protein coupled receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9892621
heparin binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity
Source: CACAO
Inferred from direct assayⁱ
- 22532826
acute-phase response
Source: UniProtKB
Non-traceable author statementⁱ
- 9815279
cellular protein metabolic process Source: Reactome
cytokine-mediated signaling pathway Source: Reactome
G-protein coupled receptor signaling pathway Source: Reactome
innate immune response Source: Reactome
lymphocyte chemotaxis
Source: UniProtKB
Inferred from direct assayⁱ
- 7636186
macrophage chemotaxis
Source: UniProtKB
Inferred from direct assayⁱ
- 7561109
negative regulation of inflammatory response
Source: UniProtKB
Non-traceable author statementⁱ
- 9823935
neutrophil chemotaxis
Source: UniProtKB
Non-traceable author statementⁱ
- 12557751
platelet activation
Source: UniProtKB
Non-traceable author statementⁱ
- 1697614
positive regulation of cell adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 11830469
- 9252455
positive regulation of cytokine secretion
Source: UniProtKB
Inferred from direct assayⁱ
- 12857601
positive regulation of cytosolic calcium ion concentration
Source: UniProtKB
Inferred from direct assayⁱ
- 9892621
positive regulation of interleukin-1 secretion
Source: UniProtKB
Non-traceable author statementⁱ
- 12857601
receptor-mediated endocytosis Source: Reactome
regulation of protein secretion
Source: UniProtKB
Non-traceable author statementⁱ
- 9605178

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Heparin-binding
Biological process	Acute phase

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3000471 Scavenging by Class B Receptors R-HSA-416476 G alpha (q) signalling events R-HSA-418594 G alpha (i) signalling events R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-879415 Advanced glycosylation endproduct receptor signaling R-HSA-933542 TRAF6 mediated NF-kB activation R-HSA-977225 Amyloid fiber formation

Reactomeⁱ

R-HSA-3000471 Scavenging by Class B Receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-879415 Advanced glycosylation endproduct receptor signaling
R-HSA-933542 TRAF6 mediated NF-kB activation
R-HSA-977225 Amyloid fiber formation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serum amyloid A-1 protein Short name: SAA Cleaved into the following 6 chains: Amyloid protein A Alternative name(s): Amyloid fibril protein AA Serum amyloid protein A(2-104) Serum amyloid protein A(3-104) Serum amyloid protein A(2-103) Serum amyloid protein A(2-102) Serum amyloid protein A(4-101)
Gene namesⁱ	Name:SAA1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173432.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10513 SAA1
MIMⁱ	104750 gene
neXtProtⁱ	NX_P0DJI8

Keywords - Cellular componentⁱ

Amyloid, HDL, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.1 Publication

Elevated serum SAA1 protein levels may be associated with lung cancer.1 Publication

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	19	R → A: Reduces affinity for heparin and nearly abolishes association with HDL; when associated with A-80 and A-89. 1 Publication	1
Mutagenesisⁱ	33	R → A: Reduces affinity for heparin; when associated with A-37 and A-65. 1 Publication	1
Mutagenesisⁱ	37	R → A: Reduces affinity for heparin; when associated with A-33 and A-65. 1 Publication	1
Mutagenesisⁱ	65	R → A: Reduces affinity for heparin; when associated with A-33 and A-37. 1 Publication	1
Mutagenesisⁱ	80	R → A: Reduces affinity for heparin and nearly abolishes association with HDL; when associated with A-18 and A-89. 1 Publication	1
Mutagenesisⁱ	89	H → A: Reduces affinity for heparin and nearly abolishes association with HDL; when associated with A-18 and A-80. 1 Publication	1

Keywords - Diseaseⁱ

Amyloidosis

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6288
MalaCards human disease database More...MalaCardsⁱ	SAA1
Orphanetⁱ	85445 Secondary amyloidosis

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00062 Human Serum Albumin DB00064 Serum albumin iodonated

DrugBankⁱ

DB00062 Human Serum Albumin
DB00064 Serum albumin iodonated

Polymorphism and mutation databases

BioMutaⁱ	SAA1
DMDMⁱ	395406826

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 18	9 PublicationsAdd BLAST	18
ChainⁱPRO_0000031575	19 – 122	Serum amyloid A-1 proteinAdd BLAST	104
ChainⁱPRO_0000031576	19 – 94	Amyloid protein AAdd BLAST	76
ChainⁱPRO_0000031577	20 – 122	Serum amyloid protein A(2-104)Add BLAST	103
ChainⁱPRO_0000031578	20 – 121	Serum amyloid protein A(2-103)Add BLAST	102
ChainⁱPRO_0000031579	20 – 120	Serum amyloid protein A(2-102)Add BLAST	101
ChainⁱPRO_0000031580	21 – 122	Serum amyloid protein A(3-104)Add BLAST	102
ChainⁱPRO_0000031581	22 – 119	Serum amyloid protein A(4-101)Add BLAST	98
PropeptideⁱPRO_0000031582	95 – 122	Often cleaved during amyloidogenesisAdd BLAST	28

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	101	N4,N4-dimethylasparagine1 Publication		1

Post-translational modificationⁱ

This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.

Keywords - PTMⁱ

Methylation

Proteomic databases

EPDⁱ	P0DJI8
PaxDbⁱ	P0DJI8
PeptideAtlas More...PeptideAtlasⁱ	P0DJI8
PRIDEⁱ	P0DJI8
ProteomicsDBⁱ	52549

PTM databases

iPTMnetⁱ	P0DJI8
PhosphoSitePlusⁱ	P0DJI8

Expressionⁱ

Tissue specificityⁱ

Expressed by the liver; secreted in plasma (at protein level).3 Publications

Inductionⁱ

Upon cytokine stimulation.

Gene expression databases

Bgeeⁱ	ENSG00000173432 Expressed in 89 organ(s), highest expression level in liver
CleanExⁱ	HS_SAA1
ExpressionAtlasⁱ	P0DJI8 baseline and differential
Genevisibleⁱ	P0DJI8 HS

Interactionⁱ

Subunit structureⁱ

Homohexamer; dimer of trimers. Can form amyloid fibrils after partial proteolysis; the native, undenatured protein does not form amyloid fibrils (in vitro). Apolipoprotein of the HDL complex. Binds to heparin.2 Publications

GO - Molecular functionⁱ

chemoattractant activity Source: GO_Central
G-protein coupled receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9892621

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112196, 2 interactors
STRINGⁱ	9606.ENSP00000348918

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	19 – 45	Combined sources	27
Helixⁱ	51 – 65	Combined sources	15
Helixⁱ	67 – 86	Combined sources	20
Helixⁱ	91 – 105	Combined sources	15
Helixⁱ	110 – 113	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P0DJI8
SMRⁱ	P0DJI8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	19 – 45	Important for amyloid formation; forms amyloid fibrils in vitroAdd BLAST		27

Sequence similaritiesⁱ

Belongs to the SAA family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IXU4 Eukaryota ENOG410YSBK LUCA
InParanoidⁱ	P0DJI8
KEGG Orthology (KO) More...KOⁱ	K17310
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G17YH
PhylomeDBⁱ	P0DJI8
TreeFamⁱ	TF332544

Family and domain databases

InterProⁱ	View protein in InterPro IPR000096 Serum_amyloid_A
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00277 SAA, 1 hit
PIRSFⁱ	PIRSF002472 Serum_amyloid_A, 1 hit
PRINTSⁱ	PR00306 SERUMAMYLOID
SMARTⁱ	View protein in SMART SM00197 SAA, 1 hit
PROSITEⁱ	View protein in PROSITE PS00992 SAA, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P0DJI8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKLLTGLVFC SLVLGVSSRS FFSFLGEAFD GARDMWRAYS DMREANYIGS 
        60         70         80         90        100
DKYFHARGNY DAAKRGPGGV WAAEAISDAR ENIQRFFGHG AEDSLADQAA 
       110        120 
NEWGRSGKDP NHFRPAGLPE KY

Length:122

Mass (Da):13,532

Last modified:July 11, 2012 - v1

Checksum:ⁱ43A57D56B37CB173

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E9PQD6	E9PQD6_HUMAN		Serum amyloid A protein Serum amyloid A protein	SAA1	122	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	71	W → R AA sequence (PubMed:6155694).Curated	1
Sequence conflictⁱ	71	W → R AA sequence (PubMed:5055786).Curated	1
Sequence conflictⁱ	77	S → T in AC107948 (PubMed:16554811).Curated	1
Sequence conflictⁱ	96 – 101	ADQAAN → SEATVK AA sequence (PubMed:1546977).Curated	6
Sequence conflictⁱ	101	N → D in AAH07022 (PubMed:15489334).Curated	1
Sequence conflictⁱ	119	P → S in AAA60297 (PubMed:3839415).Curated	1

Mass spectrometryⁱ

Molecular mass is 11702±14 Da from positions 19 - 122. Determined by MALDI. 1 Publication

Molecular mass is 11682.7 Da from positions 19 - 122. Determined by MALDI. 1 Publication

Molecular mass is 11526.5 Da from positions 20 - 122. Determined by MALDI. 1 Publication

Molecular mass is 11439.6 Da from positions 21 - 122. Determined by MALDI. 1 Publication

Molecular mass is 11363.6 Da from positions 20 - 121. Determined by MALDI. 1 Publication

Molecular mass is 11235.6 Da from positions 20 - 120. Determined by MALDI. 1 Publication

Molecular mass is 10872.6 Da from positions 22 - 119. Determined by MALDI. 1 Publication

Molecular mass is 8337.5±0.8 Da from positions 19 - 94. Determined by ESI. With variants Ala-70, Val-75, Asn-78 and 86-Leu-Thr-87.1 Publication

Molecular mass is 8390.9±0.2 Da from positions 19 - 94. Determined by ESI. With variant Ala-70.1 Publication

Polymorphismⁱ

At least 5 different SAA1 alleles have been described: SAA1.1 (SAA1alpha), SAA1.2 (SAA1beta), SAA1.3 (SAA1gamma), SAA1.4 (SAA1delta), SAA1.5 (also named SAA1beta but which differs from SAA1.2). We use here the revised nomenclature described in PubMed:10211414. The sequence shown is that of SAA1.1.

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_006925	15	G → S. Corresponds to variant dbSNP:rs712021Ensembl.	1
Natural variantⁱVAR_006926	70	V → A in allele SAA1.2, SAA1.3, SAA1.4 and SAA1.5. 1 Publication	1
Natural variantⁱVAR_006927	75	A → V in allele SAA1.2, SAA1.4 and SAA1.5. 2 Publications	1
Natural variantⁱVAR_006928	78	D → N in allele SAA1.4. 2 Publications	1
Natural variantⁱVAR_057167	86	F → L. Corresponds to variant dbSNP:rs1059559Ensembl.	1
Natural variantⁱVAR_006931	90	G → D in allele SAA1.2.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M10906 mRNA Translation: AAA60297.1 M23698 mRNA Translation: AAA64799.1 X56652 Genomic DNA Translation: CAA39974.1 CR542241 mRNA Translation: CAG47037.1 AC107948 Genomic DNA No translation available. BC007022 mRNA Translation: AAH07022.1 BC105796 mRNA Translation: AAI05797.1 X51439 mRNA Translation: CAA35804.1 X51441 mRNA Translation: CAA35806.1 X51442 mRNA Translation: CAA35807.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7835.1
PIRⁱ	A22342 YLHUS I39456
NCBI Reference Sequences More...RefSeqⁱ	NP_000322.2, NM_000331.5 NP_001171477.1, NM_001178006.2 NP_954630.1, NM_199161.4
UniGeneⁱ	Hs.632144 Hs.731376 Hs.734161

Genome annotation databases

Ensemblⁱ	ENST00000356524; ENSP00000348918; ENSG00000173432 ENST00000405158; ENSP00000384906; ENSG00000173432
GeneIDⁱ	6288
KEGGⁱ	hsa:6288
UCSC genome browser More...UCSCⁱ	uc057zpu.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P0DJI8	Serum amyloid A-2 protein		HUMAN		122	UniRef90_P0DJI8
Serum amyloid A protein (Fragment)		PONAB		122
Serum amyloid A protein		PANTR		122
Serum amyloid A protein		PANPA		122
Serum amyloid A protein		NOMLE		122
+14

Protein	Similar proteins		Species	Score	Length	Source
P0DJI8	Serum amyloid A-2 protein		HUMAN		122	UniRef50_P0DJI8
Serum amyloid A-2 protein		RABIT		122
Serum amyloid A protein		SHEEP		112
Serum amyloid A protein		PONAB		122
Serum amyloid A protein		PANPA		122
+76

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M10906 mRNA Translation: AAA60297.1 M23698 mRNA Translation: AAA64799.1 X56652 Genomic DNA Translation: CAA39974.1 CR542241 mRNA Translation: CAG47037.1 AC107948 Genomic DNA No translation available. BC007022 mRNA Translation: AAH07022.1 BC105796 mRNA Translation: AAI05797.1 X51439 mRNA Translation: CAA35804.1 X51441 mRNA Translation: CAA35806.1 X51442 mRNA Translation: CAA35807.1
CCDSⁱ	CCDS7835.1
PIRⁱ	A22342 YLHUS I39456
RefSeqⁱ	NP_000322.2, NM_000331.5 NP_001171477.1, NM_001178006.2 NP_954630.1, NM_199161.4
UniGeneⁱ	Hs.632144 Hs.731376 Hs.734161

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4IP8	X-ray	2.19	A/B/C/D	19-122	[»]
	4IP9	X-ray	2.50	A/B	19-122	[»]
ProteinModelPortalⁱ	P0DJI8
SMRⁱ	P0DJI8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112196, 2 interactors
STRINGⁱ	9606.ENSP00000348918

Chemistry databases

DrugBankⁱ	DB00062 Human Serum Albumin DB00064 Serum albumin iodonated

DrugBankⁱ

DB00062 Human Serum Albumin
DB00064 Serum albumin iodonated

PTM databases

iPTMnetⁱ	P0DJI8
PhosphoSitePlusⁱ	P0DJI8

Polymorphism and mutation databases

BioMutaⁱ	SAA1
DMDMⁱ	395406826

Proteomic databases

EPDⁱ	P0DJI8
PaxDbⁱ	P0DJI8
PeptideAtlasⁱ	P0DJI8
PRIDEⁱ	P0DJI8
ProteomicsDBⁱ	52549

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000356524; ENSP00000348918; ENSG00000173432 ENST00000405158; ENSP00000384906; ENSG00000173432
GeneIDⁱ	6288
KEGGⁱ	hsa:6288
UCSCⁱ	uc057zpu.1 human

Organism-specific databases

CTDⁱ	6288
DisGeNETⁱ	6288
EuPathDBⁱ	HostDB:ENSG00000173432.10
GeneCardsⁱ	SAA1
HGNCⁱ	HGNC:10513 SAA1
MalaCardsⁱ	SAA1
MIMⁱ	104750 gene
neXtProtⁱ	NX_P0DJI8
Orphanetⁱ	85445 Secondary amyloidosis
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IXU4 Eukaryota ENOG410YSBK LUCA
InParanoidⁱ	P0DJI8
KOⁱ	K17310
OrthoDBⁱ	EOG091G17YH
PhylomeDBⁱ	P0DJI8
TreeFamⁱ	TF332544

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3000471 Scavenging by Class B Receptors R-HSA-416476 G alpha (q) signalling events R-HSA-418594 G alpha (i) signalling events R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-879415 Advanced glycosylation endproduct receptor signaling R-HSA-933542 TRAF6 mediated NF-kB activation R-HSA-977225 Amyloid fiber formation

Reactomeⁱ

R-HSA-3000471 Scavenging by Class B Receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-879415 Advanced glycosylation endproduct receptor signaling
R-HSA-933542 TRAF6 mediated NF-kB activation
R-HSA-977225 Amyloid fiber formation

Miscellaneous databases

ChiTaRSⁱ	SAA1 human
GeneWikiⁱ	Serum_amyloid_A1
GenomeRNAiⁱ	6288
Protein Ontology More...PROⁱ	PR:P0DJI8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000173432 Expressed in 89 organ(s), highest expression level in liver
CleanExⁱ	HS_SAA1
ExpressionAtlasⁱ	P0DJI8 baseline and differential
Genevisibleⁱ	P0DJI8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000096 Serum_amyloid_A
Pfamⁱ	View protein in Pfam PF00277 SAA, 1 hit
PIRSFⁱ	PIRSF002472 Serum_amyloid_A, 1 hit
PRINTSⁱ	PR00306 SERUMAMYLOID
SMARTⁱ	View protein in SMART SM00197 SAA, 1 hit
PROSITEⁱ	View protein in PROSITE PS00992 SAA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SAA1_HUMAN
Accessionⁱ	P0DJI8Primary (citable) accession number: P0DJI8 Secondary accession number(s): P02735 Q9UCL0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 11, 2012
	Last sequence update:	July 11, 2012
	Last modified:	October 10, 2018
	This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P0DJI8 (SAA1_HUMAN)

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Serum amyloid A-1 protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Cytoskeleton

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Mass spectrometryⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ