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UniProtKB - P0DJI8 (SAA1_HUMAN)

Entry version 73 (10 Feb 2021)
Sequence version 1 (11 Jul 2012)
Previous versions | rss
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Protein

Serum amyloid A-1 protein

Gene

SAA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major acute phase protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding
Biological processAcute phase

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P0DJI8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3000471, Scavenging by Class B Receptors
R-HSA-416476, G alpha (q) signalling events
R-HSA-418594, G alpha (i) signalling events
R-HSA-444473, Formyl peptide receptors bind formyl peptides and many other ligands
R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
R-HSA-879415, Advanced glycosylation endproduct receptor signaling
R-HSA-933542, TRAF6 mediated NF-kB activation
R-HSA-977225, Amyloid fiber formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serum amyloid A-1 protein
Short name:
SAA
Cleaved into the following 6 chains:
Amyloid protein A
Alternative name(s):
Amyloid fibril protein AA
Serum amyloid protein A(2-104)
Serum amyloid protein A(3-104)
Serum amyloid protein A(2-103)
Serum amyloid protein A(2-102)
Serum amyloid protein A(4-101)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SAA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10513, SAA1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		104750, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P0DJI8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000173432.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, HDL, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.1 Publication
Elevated serum SAA1 protein levels may be associated with lung cancer.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi19R → A: Reduces affinity for heparin and nearly abolishes association with HDL; when associated with A-80 and A-89. 1 Publication1
Mutagenesisi33R → A: Reduces affinity for heparin; when associated with A-37 and A-65. 1 Publication1
Mutagenesisi37R → A: Reduces affinity for heparin; when associated with A-33 and A-65. 1 Publication1
Mutagenesisi65R → A: Reduces affinity for heparin; when associated with A-33 and A-37. 1 Publication1
Mutagenesisi80R → A: Reduces affinity for heparin and nearly abolishes association with HDL; when associated with A-18 and A-89. 1 Publication1
Mutagenesisi89H → A: Reduces affinity for heparin and nearly abolishes association with HDL; when associated with A-18 and A-80. 1 Publication1

Keywords - Diseasei

Amyloidosis

Organism-specific databases

DisGeNET

More...DisGeNETi		6288

MalaCards human disease database

More...MalaCardsi		SAA1

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		85445, AA amyloidosis

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P0DJI8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SAA1

Domain mapping of disease mutations (DMDM)

More...DMDMi		395406826

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 189 PublicationsAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003157519 – 122Serum amyloid A-1 proteinAdd BLAST104
ChainiPRO_000003157619 – 94Amyloid protein AAdd BLAST76
ChainiPRO_000003157720 – 122Serum amyloid protein A(2-104)Add BLAST103
ChainiPRO_000003157820 – 121Serum amyloid protein A(2-103)Add BLAST102
ChainiPRO_000003157920 – 120Serum amyloid protein A(2-102)Add BLAST101
ChainiPRO_000003158021 – 122Serum amyloid protein A(3-104)Add BLAST102
ChainiPRO_000003158122 – 119Serum amyloid protein A(4-101)Add BLAST98
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000003158295 – 122Often cleaved during amyloidogenesisAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei101N4,N4-dimethylasparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P0DJI8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P0DJI8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P0DJI8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0DJI8

PeptideAtlas

More...PeptideAtlasi		P0DJI8

PRoteomics IDEntifications database

More...PRIDEi		P0DJI8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52549

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P0DJI8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P0DJI8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the liver; secreted in plasma (at protein level).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Upon cytokine stimulation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000173432, Expressed in liver and 107 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P0DJI8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P0DJI8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000173432, Group enriched (adipose tissue, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer; dimer of trimers. Can form amyloid fibrils after partial proteolysis; the native, undenatured protein does not form amyloid fibrils (in vitro). Apolipoprotein of the HDL complex. Binds to heparin.

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112196, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000384906

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P0DJI8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1122
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0DJI8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni19 – 45Important for amyloid formation; forms amyloid fibrils in vitroAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S4PB, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_129936_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0DJI8

Database of Orthologous Groups

More...OrthoDBi		1417043at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0DJI8

TreeFam database of animal gene trees

More...TreeFami		TF332544

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000096, Serum_amyloid_A

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00277, SAA, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002472, Serum_amyloid_A, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00306, SERUMAMYLOID

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00197, SAA, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00992, SAA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P0DJI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLTGLVFC SLVLGVSSRS FFSFLGEAFD GARDMWRAYS DMREANYIGS 
        60         70         80         90        100
DKYFHARGNY DAAKRGPGGV WAAEAISDAR ENIQRFFGHG AEDSLADQAA 
       110        120 
NEWGRSGKDP NHFRPAGLPE KY
Length:122
Mass (Da):13,532
Last modified:July 11, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43A57D56B37CB173
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQD6E9PQD6_HUMAN
Serum amyloid A protein
SAA1
122Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISW8A0A3B3ISW8_HUMAN
Serum amyloid A protein
SAA1
77Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti71W → R AA sequence (PubMed:6155694).Curated1
Sequence conflicti71W → R AA sequence (PubMed:5055786).Curated1
Sequence conflicti77S → T in AC107948 (PubMed:16554811).Curated1
Sequence conflicti96 – 101ADQAAN → SEATVK AA sequence (PubMed:1546977).Curated6
Sequence conflicti101N → D in AAH07022 (PubMed:15489334).Curated1
Sequence conflicti119P → S in AAA60297 (PubMed:3839415).Curated1

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 11702±14 Da. Determined by MALDI. 1 Publication
Molecular mass is 11682.7 Da. Determined by MALDI. 1 Publication
Molecular mass is 11526.5 Da. Determined by MALDI. 1 Publication
Molecular mass is 11439.6 Da. Determined by MALDI. 1 Publication
Molecular mass is 11363.6 Da. Determined by MALDI. 1 Publication
Molecular mass is 11235.6 Da. Determined by MALDI. 1 Publication
Molecular mass is 10872.6 Da. Determined by MALDI. 1 Publication
Molecular mass is 8337.5±0.8 Da. Determined by ESI. With variants Ala-70, Val-75, Asn-78 and 86-Leu-Thr-87.1 Publication
Molecular mass is 8390.9±0.2 Da. Determined by ESI. With variant Ala-70.1 Publication

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

At least 5 different SAA1 alleles have been described: SAA1.1 (SAA1alpha), SAA1.2 (SAA1beta), SAA1.3 (SAA1gamma), SAA1.4 (SAA1delta), SAA1.5 (also named SAA1beta but which differs from SAA1.2). We use here the revised nomenclature described in PubMed:10211414. The sequence shown is that of SAA1.1.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00692515G → S. Corresponds to variant dbSNP:rs1232745554Ensembl.1
Natural variantiVAR_00692670V → A in allele SAA1.2, SAA1.3, SAA1.4 and SAA1.5. 1 Publication1
Natural variantiVAR_00692775A → V in allele SAA1.2, SAA1.4 and SAA1.5. 2 Publications1
Natural variantiVAR_00692878D → N in allele SAA1.4. 2 PublicationsCorresponds to variant dbSNP:rs557915415Ensembl.1
Natural variantiVAR_05716786F → L. Corresponds to variant dbSNP:rs1059559EnsemblClinVar.1
Natural variantiVAR_00693190G → D in allele SAA1.2. Corresponds to variant dbSNP:rs79681911EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M10906 mRNA Translation: AAA60297.1
M23698 mRNA Translation: AAA64799.1
X56652 Genomic DNA Translation: CAA39974.1
CR542241 mRNA Translation: CAG47037.1
AC107948 Genomic DNA No translation available.
BC007022 mRNA Translation: AAH07022.1
BC105796 mRNA Translation: AAI05797.1
X51439 mRNA Translation: CAA35804.1
X51441 mRNA Translation: CAA35806.1
X51442 mRNA Translation: CAA35807.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7835.1

Protein sequence database of the Protein Information Resource

More...PIRi		A22342, YLHUS
I39456

NCBI Reference Sequences

More...RefSeqi		NP_000322.2, NM_000331.5
NP_001171477.1, NM_001178006.2
NP_954630.1, NM_199161.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000356524; ENSP00000348918; ENSG00000173432
ENST00000405158; ENSP00000384906; ENSG00000173432

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6288

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6288

UCSC genome browser

More...UCSCi		uc057zpu.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10906 mRNA Translation: AAA60297.1
M23698 mRNA Translation: AAA64799.1
X56652 Genomic DNA Translation: CAA39974.1
CR542241 mRNA Translation: CAG47037.1
AC107948 Genomic DNA No translation available.
BC007022 mRNA Translation: AAH07022.1
BC105796 mRNA Translation: AAI05797.1
X51439 mRNA Translation: CAA35804.1
X51441 mRNA Translation: CAA35806.1
X51442 mRNA Translation: CAA35807.1
CCDSiCCDS7835.1
PIRiA22342, YLHUS
I39456
RefSeqiNP_000322.2, NM_000331.5
NP_001171477.1, NM_001178006.2
NP_954630.1, NM_199161.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IP8X-ray2.19A/B/C/D19-122[»]
4IP9X-ray2.50A/B19-122[»]
6MSTelectron microscopy2.70A/B/C/D/E/F/G/H/I/J/K/L20-85[»]
SMRiP0DJI8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112196, 3 interactors
STRINGi9606.ENSP00000384906

PTM databases

iPTMnetiP0DJI8
PhosphoSitePlusiP0DJI8

Genetic variation databases

BioMutaiSAA1
DMDMi395406826

Proteomic databases

EPDiP0DJI8
jPOSTiP0DJI8
MassIVEiP0DJI8
PaxDbiP0DJI8
PeptideAtlasiP0DJI8
PRIDEiP0DJI8
ProteomicsDBi52549

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P0DJI8, 3 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12220, 586 antibodies

Genome annotation databases

EnsembliENST00000356524; ENSP00000348918; ENSG00000173432
ENST00000405158; ENSP00000384906; ENSG00000173432
GeneIDi6288
KEGGihsa:6288
UCSCiuc057zpu.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6288
DisGeNETi6288

GeneCards: human genes, protein and diseases

More...GeneCardsi		SAA1
HGNCiHGNC:10513, SAA1
HPAiENSG00000173432, Group enriched (adipose tissue, liver)
MalaCardsiSAA1
MIMi104750, gene
neXtProtiNX_P0DJI8
Orphaneti85445, AA amyloidosis
VEuPathDBiHostDB:ENSG00000173432.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S4PB, Eukaryota
HOGENOMiCLU_129936_0_0_1
InParanoidiP0DJI8
OrthoDBi1417043at2759
PhylomeDBiP0DJI8
TreeFamiTF332544

Enzyme and pathway databases

PathwayCommonsiP0DJI8
ReactomeiR-HSA-3000471, Scavenging by Class B Receptors
R-HSA-416476, G alpha (q) signalling events
R-HSA-418594, G alpha (i) signalling events
R-HSA-444473, Formyl peptide receptors bind formyl peptides and many other ligands
R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
R-HSA-879415, Advanced glycosylation endproduct receptor signaling
R-HSA-933542, TRAF6 mediated NF-kB activation
R-HSA-977225, Amyloid fiber formation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6288, 8 hits in 847 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SAA1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Serum_amyloid_A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6288
PharosiP0DJI8, Tbio

Protein Ontology

More...PROi		PR:P0DJI8
RNActiP0DJI8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000173432, Expressed in liver and 107 other tissues
ExpressionAtlasiP0DJI8, baseline and differential
GenevisibleiP0DJI8, HS

Family and domain databases

InterProiView protein in InterPro
IPR000096, Serum_amyloid_A
PfamiView protein in Pfam
PF00277, SAA, 1 hit
PIRSFiPIRSF002472, Serum_amyloid_A, 1 hit
PRINTSiPR00306, SERUMAMYLOID
SMARTiView protein in SMART
SM00197, SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992, SAA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0DJI8
Secondary accession number(s): P02735
, P02736, P02737, Q16730, Q16834, Q16835, Q16879, Q3KRB3, Q6FG67, Q96QN0, Q9UCK9, Q9UCL0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: July 11, 2012
Last modified: February 10, 2021
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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