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Entry version 41 (16 Jan 2019)
Sequence version 1 (18 Apr 2012)
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Protein

Testicular haploid expressed gene protein-like

Gene

THEGL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Testicular haploid expressed gene protein-like
Alternative name(s):
Theg spermatid-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THEGL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000249693.2

Human Gene Nomenclature Database

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HGNCi
HGNC:43771 THEGL

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P0DJG4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000249693

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
THEGL

Domain mapping of disease mutations (DMDM)

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DMDMi
384951201

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004168261 – 465Testicular haploid expressed gene protein-likeAdd BLAST465

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P0DJG4

PeptideAtlas

More...
PeptideAtlasi
P0DJG4

PRoteomics IDEntifications database

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PRIDEi
P0DJG4

ProteomicsDB human proteome resource

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ProteomicsDBi
52547

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0DJG4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P0DJG4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000249693 Expressed in 28 organ(s), highest expression level in right testis

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA068093

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
1528470, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P0DJG4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati174 – 192THEG 1Add BLAST19
Repeati214 – 233THEG 2Add BLAST20
Repeati260 – 279THEG 3Add BLAST20
Repeati297 – 316THEG 4Add BLAST20
Repeati333 – 352THEG 5Add BLAST20
Repeati373 – 392THEG 6Add BLAST20
Repeati409 – 428THEG 7Add BLAST20
Repeati446 – 465THEG 8Add BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWC5 Eukaryota
ENOG4111HMP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154630

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0DJG4

Identification of Orthologs from Complete Genome Data

More...
OMAi
EGLCYER

Database of Orthologous Groups

More...
OrthoDBi
1209550at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329290

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006623 THEG

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14912 THEG, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00705 THEG, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0DJG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENQEFLSSS APSEVTDGQV STEISTCSEV FQKPIVLRIL DTHRELEESE
60 70 80 90 100
DPEKHENPEE PEEVREQDQR DESEECDEPH ESYEPHAPYA PHKPRDSYAP
110 120 130 140 150
YELHGPHAAP KLLKAREPRQ LRHTREPRKS REAKETELLP SAAVMISPSL
160 170 180 190 200
ITRAPPRPQL SFLGANPVSC DFVRKCFSSR KRTPNLSKPK KQWGTPDRKL
210 220 230 240 250
FWGNQDPIRP VSQGALKAQL TKRLENLAQP KEVSCHYVPN RAQYYHSCGR
260 270 280 290 300
ESVIWEITPP ALFRQPSKRI QRLSQPNGFK RQCLLNRPFS DNSARDSLRI
310 320 330 340 350
SDPSPRILQL SVAKGTDPNY HPSKKMQTKI SLSTLSAIAT PRIIELAHPR
360 370 380 390 400
IKLEGLCYER QRSELPIRPV PPAAMIAKPS PRTIALAKSK SVHQDYLPDR
410 420 430 440 450
DAHWPVSYAT THSKASPRIQ ELANPNKRAP VRIVYYDPDV FKTKPAALKA
460
QCSQRIWELS QPLTR
Length:465
Mass (Da):53,028
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7F977C755B466EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti220L → Q in DW009623 (PubMed:15815621).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC108215 Genomic DNA No translation available.
DY655427 mRNA No translation available.
DW009623 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58899.1

NCBI Reference Sequences

More...
RefSeqi
NP_001243404.1, NM_001256475.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.573073
Hs.638565

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000512175; ENSP00000456850; ENSG00000249693

Database of genes from NCBI RefSeq genomes

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GeneIDi
100506564

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100506564

UCSC genome browser

More...
UCSCi
uc031seh.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108215 Genomic DNA No translation available.
DY655427 mRNA No translation available.
DW009623 mRNA No translation available.
CCDSiCCDS58899.1
RefSeqiNP_001243404.1, NM_001256475.1
UniGeneiHs.573073
Hs.638565

3D structure databases

ProteinModelPortaliP0DJG4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1528470, 1 interactor

PTM databases

iPTMnetiP0DJG4
PhosphoSitePlusiP0DJG4

Polymorphism and mutation databases

BioMutaiTHEGL
DMDMi384951201

Proteomic databases

PaxDbiP0DJG4
PeptideAtlasiP0DJG4
PRIDEiP0DJG4
ProteomicsDBi52547

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000512175; ENSP00000456850; ENSG00000249693
GeneIDi100506564
KEGGihsa:100506564
UCSCiuc031seh.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100506564
EuPathDBiHostDB:ENSG00000249693.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
THEGL
HGNCiHGNC:43771 THEGL
HPAiHPA068093
neXtProtiNX_P0DJG4
OpenTargetsiENSG00000249693

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWC5 Eukaryota
ENOG4111HMP LUCA
GeneTreeiENSGT00940000154630
InParanoidiP0DJG4
OMAiEGLCYER
OrthoDBi1209550at2759
TreeFamiTF329290

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0DJG4

Gene expression databases

BgeeiENSG00000249693 Expressed in 28 organ(s), highest expression level in right testis

Family and domain databases

InterProiView protein in InterPro
IPR006623 THEG
PfamiView protein in Pfam
PF14912 THEG, 4 hits
SMARTiView protein in SMART
SM00705 THEG, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHEGL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0DJG4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: April 18, 2012
Last modified: January 16, 2019
This is version 41 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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