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Entry version 27 (07 Oct 2020)
Sequence version 2 (29 Apr 2015)
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Protein

Alpha-latrotoxin-Lhe1a

Gene
N/A
Organism
Latrodectus hesperus (Western black widow spider)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Presynaptic neurotoxin that induces exhaustive neurotransmitter release from vertebrate (but not invertebrate) nerve terminals and endocrine cells. Binds to neurexin-1-alpha (NRXN1), adhesion G protein-coupled receptor L1 (ADGRL1, also known as latrophilin-1), and receptor-type tyrosine-protein phosphatase S (PTPRS), and induces neurotransmitter exocytosis through two calcium-dependent mechanisms (membrane pore formation and signaling via latrophilin) and a yet to be defined calcium-independent mechanism. Induces rapid muscle contracture and loss of twitch tension when added to the isolated and indirectly stimulated chick biventer cervicis nerve-muscle preparation.

By similarity

Miscellaneous

Is the main neurotoxin responsible for the human envenomation syndrome known as latrodectism that results from bites by Latrodectus species.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNeurotoxin, Presynaptic neurotoxin, Toxin
Biological processExocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-latrotoxin-Lhe1a1 Publication
Short name:
Alpha-LTX-Lhe1a1 Publication
Alternative name(s):
Alpha-latrotoxin1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLatrodectus hesperus (Western black widow spider)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri256737 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAraneoideaTheridiidaeLatrodectus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Secreted, Target cell membrane, Target membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20By similarityAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000041593221 – 1199Alpha-latrotoxin-Lhe1aAdd BLAST1179
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00004328771200 – 1418By similarityAdd BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi413 ↔ 1066By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Processed by furin-like proteases at both the N- and C-termini.
Contains 1 disulfide bond.By similarity

Keywords - PTMi

Disulfide bond

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the venom gland.Curated

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer; Homotetramerization is triggered by calcium and is responsible for non-vesicular release and calcium-dependent vesicular exocytosis.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0DJE3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati458 – 489ANK 1By similarityAdd BLAST32
Repeati490 – 521ANK 2Sequence analysisAdd BLAST32
Repeati525 – 554ANK 3Sequence analysisAdd BLAST30
Repeati559 – 589ANK 4Sequence analysisAdd BLAST31
Repeati593 – 622ANK 5Sequence analysisAdd BLAST30
Repeati626 – 656ANK 6Sequence analysisAdd BLAST31
Repeati660 – 690ANK 7Sequence analysisAdd BLAST31
Repeati695 – 723ANK 8Sequence analysisAdd BLAST29
Repeati729 – 758ANK 9Sequence analysisAdd BLAST30
Repeati762 – 791ANK 10Sequence analysisAdd BLAST30
Repeati795 – 824ANK 11Sequence analysisAdd BLAST30
Repeati828 – 857ANK 12Sequence analysisAdd BLAST30
Repeati862 – 891ANK 13Sequence analysisAdd BLAST30
Repeati895 – 924ANK 14Sequence analysisAdd BLAST30
Repeati928 – 957ANK 15Sequence analysisAdd BLAST30
Repeati971 – 1003ANK 16Sequence analysisAdd BLAST33
Repeati1004 – 1033ANK 17Sequence analysisAdd BLAST30
Repeati1035 – 1064ANK 18Sequence analysisAdd BLAST30
Repeati1068 – 1097ANK 19Sequence analysisAdd BLAST30
Repeati1101 – 1131ANK 20Sequence analysisAdd BLAST31
Repeati1137 – 1166ANK 21Sequence analysisAdd BLAST30
Repeati1170 – 1199ANK 22Sequence analysisAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni17 – 20Furin-like endopeptidase recognition regionBy similarity4
Regioni1026 – 10324C4.1 epitopeBy similarity7
Regioni1196 – 1199Furin-like endopeptidase recognition regionBy similarity4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Signal, Transmembrane

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 3 hits
PF12796, Ank_2, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 20 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0DJE3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIFVGETMER ANHSLVRLRR EGEELTLDEK AEICSELELQ QKYVDIASNI
60 70 80 90 100
IGDLSSLPMV GKIVGTIAAA AMTVTHVASG RLDIEQTLLG CSDLPFDQIK
110 120 130 140 150
EVLEKRFNEV DRKLESHSAA LEEITKLVEK SISAVEKTRK QMNKRFDEVM
160 170 180 190 200
KSIQDAKVSP IVSKINNFAR YFDTEKERIR GLKLNDYILK LEEPNGILLH
210 220 230 240 250
FKESRTPKDD SLQAPLFSII QEGYAVPKSI DDESAFKVLY ALLYGTQTYI
260 270 280 290 300
SVMFFLLEQY SFLANHYYEK GDLEKYDEYF NSLNNVFLDF KSSLVGTGTS
310 320 330 340 350
NNEGLIDKVL QVLMTFKNSE FLGLGKNGVD EMLNEKINLF NKIKEEIESK
360 370 380 390 400
QRMTMSETPE NFAQISFDKD ITTPIGDWRD GREVRYAVQY ASETLFSKIG
410 420 430 440 450
HWSDPVSVRE KACPTLRMPV DQTRRNVLVF RKFDNSKPQL VGEITPYLSN
460 470 480 490 500
FIDIDRDLYN AASNPDSAVG FKEFTKLNYD GANIRATFDQ GRTIFHAVAK
510 520 530 540 550
SGNDKILFGL TFLVKSTELN QPDKKGYTPI HVAADSGNAG IVNLLIQRGV
560 570 580 590 600
SINSKTYHFL QTPLHLAAQR GFVNTFQRLM ESSEININER DKDGFTPLHY
610 620 630 640 650
AVRGGERILE AFMNQIGIDV NAKSNKGLTP FHLAIIKNDW QVASTLLRNK
660 670 680 690 700
KVDINAVDEN NMTALHYAAI LGYLETTKQL INLKEINANV VSSPGLLSAL
710 720 730 740 750
HYAILYKHDD VASFLLRSSN VNVNLKALGG ITPLHLAVMQ GRKQVLSLMF
760 770 780 790 800
NIGVNIEQQT DEKYTPLHLA AMSKYPELIQ ILLDQDSNFE AKTNSGATPL
810 820 830 840 850
HLATFKGKSQ AALILLNNEV NWRDTDENGQ MPIHGAATTG LLDVAQAIIS
860 870 880 890 900
IDATVLDIED KNSDTPLNLA AQNSHIDAVK YFIDQGADIN TRNKNGHAPL
910 920 930 940 950
LAFSKKGNLD MVKYLFDKNA NVYIADNNGM NFFYYAVRNG HLNIIKYAMS
960 970 980 990 1000
EKDKFEWSNI DNNRRDECPK EECAISHFAV CDAVQFDKIE IVKFFIGTLG
1010 1020 1030 1040 1050
NFNICGPLHQ AARYGHLHIV KYLVEEEVLS VDGSKTDTPL CYASENGHLA
1060 1070 1080 1090 1100
VVQYLVSNGA KVNHDCANGM TAIDKAITKN HLQVVQFLAA NGVDFRRKNS
1110 1120 1130 1140 1150
RGATPFLTAV AENAFDIAEY LIREKRQDIN INEQNVDKET ALHLAVYYKN
1160 1170 1180 1190 1200
LQMIKLLVKY GIDVTIRNAY DKTVLDIATD AKFSNIVKYL KKNSGKFRRE
1210 1220 1230 1240 1250
YKSSYGEHSF LQTNEISRFI DGKSIEHDHP QFINADNESS QLFSGTASKI
1260 1270 1280 1290 1300
DVIGTLLLID VLIRYFSKQG YISKESDSAS DGITQAAALS ITEKFEDVLN
1310 1320 1330 1340 1350
SLPNKSAKEQ VDLADVHGKV YAALKSGRNS QIHQILCSSL KSISTLKPED
1360 1370 1380 1390 1400
MEKLVSVIMN SHSSLSMPEA TDSANEAYGE TLHLFGESCR HSEDYISQKF
1410
STNPFSFESE KKIQKISI
Length:1,418
Mass (Da):159,121
Last modified:April 29, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i34D413B17A7ECEE4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti583S → P AA sequence (PubMed:22001442).Curated1
Sequence conflicti1192K → T in AIP91371 (PubMed:23339183).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KM382064 Genomic DNA Translation: AIP91371.1
KC414032 Genomic DNA Translation: AGD80166.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KM382064 Genomic DNA Translation: AIP91371.1
KC414032 Genomic DNA Translation: AGD80166.1

3D structure databases

SMRiP0DJE3
ModBaseiSearch...

Family and domain databases

Gene3Di1.25.40.20, 4 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023, Ank, 3 hits
PF12796, Ank_2, 4 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 20 hits
SUPFAMiSSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 11 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLATA_LATHE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0DJE3
Secondary accession number(s): A0A089FYN5, L7XGA0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: April 29, 2015
Last modified: October 7, 2020
This is version 27 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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