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Protein

Neurexin-1-beta

Gene

Nrxn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi137CalciumBy similarity1
Metal bindingi154Calcium; via carbonyl oxygenBy similarity1
Metal bindingi236Calcium; via carbonyl oxygenBy similarity1
Metal bindingi238CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAngiogenesis, Cell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexin-1-beta
Alternative name(s):
Neurexin I-beta
Gene namesi
Name:Nrxn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1096391 Nrxn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei393 – 413HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi137D → A: Loss of NLGN1-binding. No effect on CBLN1-binding. 1 Publication1
Mutagenesisi238N → A: Loss of NLGN1-binding. No effect on CBLN1-binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 46Sequence analysisAdd BLAST46
ChainiPRO_000041263047 – 468Neurexin-1-betaAdd BLAST422

Post-translational modificationi

Highly O-glycosylated and minor N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PeptideAtlasiP0DI97
PRIDEiP0DI97

Expressioni

Gene expression databases

BgeeiENSMUSG00000024109 Expressed in 194 organ(s), highest expression level in visual cortex
ExpressionAtlasiP0DI97 baseline and differential
GenevisibleiP0DI97 MM

Interactioni

Subunit structurei

The cytoplasmic C-terminal region binds to CASK. Binds NLGN1, NLGN2 and NLGN3, DAG1 (alpha-dystroglycan) and alpha-latrotoxin. Binding to neuroligins is calcium-dependent, and the binding preference ranks as follow: NLGN1 > NLGN4 >> NLGN3 > NLGN2 (By similarity). Interacts with CBLN2 and more weakly with CBLN4 (PubMed:22220752). Interacts with CBLN1; interaction is CBLN1 hexamer form-dependent; CBLN1-binding is calcium-independent; isoform 1b does not interact with CBLN1 (PubMed:21410790, PubMed:22220752).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Cbln1Q9R1714EBI-2794440,EBI-2794140

GO - Molecular functioni

Protein-protein interaction databases

IntActiP0DI97, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliP0DI97
SMRiP0DI97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 285Laminin G-likePROSITE-ProRule annotationAdd BLAST199

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni201 – 230Essential for interaction with CBLN1; modulates interaction affinity with NLGN1, NLGN2 and NLGN3; prevents interaction with DAG1/alpha-dystroglycan; modulates interaction with alpha-latrotoxinBy similarityAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi53 – 65His-richAdd BLAST13
Compositional biasi315 – 318Poly-Thr4
Compositional biasi400 – 403Poly-Ala4

Sequence similaritiesi

Belongs to the neurexin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3514 Eukaryota
ENOG410XNU6 LUCA
GeneTreeiENSGT00760000118991
KOiK07377
TreeFamiTF334142

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
IPR037440 Neurexin
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom
PANTHERiPTHR44287 PTHR44287, 2 hits
PfamiView protein in Pfam
PF02210 Laminin_G_2, 1 hit
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00282 LamG, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50025 LAM_G_DOMAIN, 1 hit

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus.
Isoform 1b (identifier: P0DI97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYQRMLRCGA DLGSPGGGSG GGAGGRLALI WIVPLTLSGL LGVAWGASSL
60 70 80 90 100
GAHHIHHFHG SSKHHSVPIA IYRSPASLRG GHAGTTYIFS KGGGQITYKW
110 120 130 140 150
PPNDRPSTRA DRLAIGFSTV QKEAVLVRVD SSSGLGDYLE LHIHQGKIGV
160 170 180 190 200
KFNVGTDDIA IEESNAIIND GKYHVVRFTR SGGNATLQVD SWPVIERYPA
210 220 230 240 250
GNNDNERLAI ARQRIPYRLG RVVDEWLLDK GRQLTIFNSQ ATIIIGGKEQ
260 270 280 290 300
GQPFQGQLSG LYYNGLKVLN MAAENDANIA IVGNVRLVGE VPSSMTTEST
310 320 330 340 350
ATAMQSEMST SIMETTTTLA TSTARRGKPP TKEPISQTTD DILVASAECP
360 370 380 390 400
SDDEDIDPCE PSSGGLANPT RVGGREPYPG SAEVIRESSS TTGMVVGIVA
410 420 430 440 450
AAALCILILL YAMYKYRNRD EGSYHVDESR NYISNSAQSN GAVVKEKQPS
460
SAKSANKNKK NKDKEYYV
Length:468
Mass (Da):50,223
Last modified:September 21, 2011 - v1
Checksum:iF118A9053BAB4E21
GO
Isoform 1a (identifier: Q9CS84-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9CS84.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,514
Mass (Da):166,169
GO
Isoform 2a (identifier: Q9CS84-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-2B
The sequence of this isoform can be found in the external entry Q9CS84.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,507
Mass (Da):165,387
GO
Isoform 3a (identifier: Q9CS84-3) [UniParc]FASTAAdd to basket
Also known as: Alpha-2C
The sequence of this isoform can be found in the external entry Q9CS84.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,499
Mass (Da):164,596
GO
Isoform 4a (identifier: Q9CS84-4) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9CS84.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:1,496
Mass (Da):164,369
GO
Isoform 5a (identifier: Q9CS84-5) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9CS84.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,477
Mass (Da):161,824
GO
Isoform 6 (identifier: Q9CS84-6) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9CS84.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by alternative promoter usage and alternative splicing.1 Publication
Length:139
Mass (Da):15,289
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466537 Genomic DNA Translation: EDL38657.1
CCDSiCCDS84341.1 [P0DI97-1]
RefSeqiNP_001333888.1, NM_001346959.1 [P0DI97-1]
UniGeneiMm.478418
Mm.491332

Genome annotation databases

EnsembliENSMUST00000174337; ENSMUSP00000133724; ENSMUSG00000024109 [P0DI97-1]
GeneIDi18189
KEGGimmu:18189

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466537 Genomic DNA Translation: EDL38657.1
CCDSiCCDS84341.1 [P0DI97-1]
RefSeqiNP_001333888.1, NM_001346959.1 [P0DI97-1]
UniGeneiMm.478418
Mm.491332

3D structure databases

ProteinModelPortaliP0DI97
SMRiP0DI97
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0DI97, 2 interactors

Proteomic databases

PeptideAtlasiP0DI97
PRIDEiP0DI97

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000174337; ENSMUSP00000133724; ENSMUSG00000024109 [P0DI97-1]
GeneIDi18189
KEGGimmu:18189

Organism-specific databases

CTDi9378
MGIiMGI:1096391 Nrxn1

Phylogenomic databases

eggNOGiKOG3514 Eukaryota
ENOG410XNU6 LUCA
GeneTreeiENSGT00760000118991
KOiK07377
TreeFamiTF334142

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSiNrxn1 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024109 Expressed in 194 organ(s), highest expression level in visual cortex
ExpressionAtlasiP0DI97 baseline and differential
GenevisibleiP0DI97 MM

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
IPR037440 Neurexin
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom
PANTHERiPTHR44287 PTHR44287, 2 hits
PfamiView protein in Pfam
PF02210 Laminin_G_2, 1 hit
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00282 LamG, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50025 LAM_G_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNRX1B_MOUSE
AccessioniPrimary (citable) accession number: P0DI97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 7, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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