UniProtKB - P0DI87 (OXLA_BOTIN)
Protein
L-amino-acid oxidase
Gene
N/A
Organism
Bothrops insularis (Golden lancehead) (Lachesis insularis)
Status
Functioni
Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity). In addition, this protein induces apoptosis and necrosis and has inhibitory effects on rat kidney function (decrease of blood flow and glomerular filtration).By similarity1 Publication
Catalytic activityi
- EC:1.4.3.2
Cofactori
FADBy similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 43 – 44 | FADBy similarity | 2 |
GO - Molecular functioni
- L-amino-acid oxidase activity Source: UniProtKB-EC
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- defense response to bacterium Source: UniProtKB-KW
- hemolysis in other organism Source: UniProtKB-KW
Keywordsi
Molecular function | Antibiotic, Antimicrobial, Hemostasis impairing toxin, Oxidoreductase, Toxin |
Biological process | Apoptosis, Cytolysis, Hemolysis |
Ligand | FAD, Flavoprotein |
Names & Taxonomyi
Protein namesi | |
Organismi | Bothrops insularis (Golden lancehead) (Lachesis insularis) |
Taxonomic identifieri | 8723 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Crotalinae › Bothrops |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000412594 | 1 – ›49 | L-amino-acid oxidaseAdd BLAST | ›49 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 10 ↔ ? |
Post-translational modificationi
N-glycosylated.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PRIDEi | P0DI87 |
Expressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Interactioni
Subunit structurei
Homodimer; non-covalently linked.By similarity
Family & Domainsi
Sequence similaritiesi
i Sequence
Sequence statusi: Fragment.
P0DI87-1 [UniParc]FASTAAdd to basket
10 20 30 40
ADDKNPLEEC FREDDYEGFL EIAKNGLSTT SNPKRVVIVG AGMSGLAAY
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 49 | 1 |
Similar proteinsi
Cross-referencesi
3D structure databases
SMRi | P0DI87 |
ModBasei | Search... |
MobiDBi | Search... |
Proteomic databases
PRIDEi | P0DI87 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
ProtoNeti | Search... |
Entry informationi
Entry namei | OXLA_BOTIN | |
Accessioni | P0DI87Primary (citable) accession number: P0DI87 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 21, 2011 |
Last sequence update: | September 21, 2011 | |
Last modified: | December 5, 2018 | |
This is version 23 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families