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Protein

Ras-related protein Rab-34, isoform NARR

Gene

RAB34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Shares its exons with RAB34, but the first 5'-exon is longer and the translation ccurs 443 base pairs upstream from RAB34 initiator, in another frame. May be produced by an alternative promoter.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-34, isoform NARR
Alternative name(s):
Nine amino-acid residue-repeats
Gene namesi
Name:RAB34
Synonyms:NARR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16519 RAB34
neXtProtiNX_P0DI83

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi83871
OpenTargetsiENSG00000109113

Polymorphism and mutation databases

BioMutaiRAB34
DMDMi347602360

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00004125332 – 198Ras-related protein Rab-34, isoform NARRAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13Phosphoserine1 Publication1
Modified residuei69Phosphothreonine1 Publication1
Modified residuei78Phosphoserine1 Publication1
Modified residuei87Phosphoserine1 Publication1
Modified residuei96Phosphoserine1 Publication1
Modified residuei123Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylated during M-phase.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP0DI83
PeptideAtlasiP0DI83
PRIDEiP0DI83
ProteomicsDBi52535

PTM databases

iPTMnetiP0DI83
PhosphoSitePlusiP0DI83
SwissPalmiP0DI83

Expressioni

Gene expression databases

ExpressionAtlasiP0DI83 baseline and differential

Interactioni

Subunit structurei

May interact with EIF5A and ERF1.

Protein-protein interaction databases

IntActiP0DI83, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP0DI83
SMRiP0DI83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 1511 Publication9
Repeati16 – 2421 Publication9
Repeati25 – 3331 Publication9
Repeati34 – 4241 Publication9
Repeati43 – 5151 Publication9
Repeati52 – 6061 Publication9
Repeati61 – 6971 Publication9
Repeati70 – 7881 Publication9
Repeati79 – 8791 Publication9
Repeati88 – 96101 Publication9
Repeati97 – 105111 Publication9
Repeati106 – 114121 Publication9
Repeati115 – 123131 Publication9

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 12513 x 9 AA approximate tandem-repeats of P-R-V-I-V-G-(S/T)-P-RAdd BLAST119

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00910000144073

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform NARR (identifier: P0DI83-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVGQPQPRDD VGSPRPRVIV GTIRPRVIVG TIRPRVIVGS ARARPPPDGT
60 70 80 90 100
PRPQLAAEES PRPRVIFGTP RARVILGSPR PRVIVSSPWP AVVVASPRPR
110 120 130 140 150
TPVGSPWPRV VVGTPRPRVI VGSPRARVAD ADPASAPSQG ALQGRRQDEH
160 170 180 190
SGTRAEGSRP GGAAPVPEEG GRFARAQRLP PPRHLRLPGA PDRHRGQI
Length:198
Mass (Da):21,118
Last modified:September 21, 2011 - v1
Checksum:iE03CF9EB3272B766
GO
Isoform 1 (identifier: Q9BZG1-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9BZG1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:259
Mass (Da):29,044
GO
Isoform 2 (identifier: Q9BZG1-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9BZG1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:251
Mass (Da):28,230
GO
Isoform 4 (identifier: Q9BZG1-4) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9BZG1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:237
Mass (Da):26,673
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010761 Genomic DNA No translation available.
CX872465 mRNA No translation available.
RefSeqiNP_001243210.1, NM_001256281.2 [P0DI83-1]
UniGeneiHs.301853

Genome annotation databases

EnsembliENST00000636154; ENSP00000490450; ENSG00000109113 [P0DI83-1]
GeneIDi83871

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010761 Genomic DNA No translation available.
CX872465 mRNA No translation available.
RefSeqiNP_001243210.1, NM_001256281.2 [P0DI83-1]
UniGeneiHs.301853

3D structure databases

ProteinModelPortaliP0DI83
SMRiP0DI83
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0DI83, 1 interactor

PTM databases

iPTMnetiP0DI83
PhosphoSitePlusiP0DI83
SwissPalmiP0DI83

Polymorphism and mutation databases

BioMutaiRAB34
DMDMi347602360

Proteomic databases

EPDiP0DI83
PeptideAtlasiP0DI83
PRIDEiP0DI83
ProteomicsDBi52535

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000636154; ENSP00000490450; ENSG00000109113 [P0DI83-1]
GeneIDi83871

Organism-specific databases

CTDi83871
DisGeNETi83871
GeneCardsiRAB34
HGNCiHGNC:16519 RAB34
neXtProtiNX_P0DI83
OpenTargetsiENSG00000109113
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00910000144073

Miscellaneous databases

ChiTaRSiRAB34 human
GenomeRNAii100861437

Gene expression databases

ExpressionAtlasiP0DI83 baseline and differential

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiNARR_HUMAN
AccessioniPrimary (citable) accession number: P0DI83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 20, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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