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Protein

Trafficking protein particle complex subunit 2B

Gene

TRAPPC2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prevents transcriptional repression and induction of cell death by ENO1. May play a role in vesicular transport from endoplasmic reticulum to Golgi.1 Publication

Miscellaneous

The gene encoding this protein appears to have arisen by retrotransposition of a cDNA from the X-linked locus TRAPPC2. The site of integration of this retrotransposed cDNA appears to lie within an intron of the ZNF547 gene, which provides a promoter and non-coding 5' exon. TRAPPC2 and this protein are indistinguishable at protein level, and both proteins have been identified and functionally characterized.

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Transcription, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 2B
Alternative name(s):
MBP-1-interacting protein 2A
Short name:
MIP-2A
Gene namesi
Name:TRAPPC2B
Synonyms:SEDLP1, TRAPPC2.19, TRAPPC2P1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000256060.2
HGNCiHGNC:10710 TRAPPC2B
neXtProtiNX_P0DI82

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10597
6399
OpenTargetsiENSG00000196459
ENSG00000256060

Polymorphism and mutation databases

DMDMi347662478

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004124541 – 140Trafficking protein particle complex subunit 2BAdd BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei119PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP0DI82
PRIDEiP0DI82
ProteomicsDBi52534

PTM databases

iPTMnetiP0DI82

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, fetal cartilage, fibroblasts, placenta and lymphocytes.1 Publication

Gene expression databases

BgeeiENSG00000256060 Expressed in 90 organ(s), highest expression level in right adrenal gland
CleanExiHS_TRAPPC2
ExpressionAtlasiP0DI82 baseline and differential
GenevisibleiP0DI82 HS

Organism-specific databases

HPAiHPA063308

Interactioni

Subunit structurei

Interacts with PITX1, SF1, and TRAPPC3 (By similarity). Can homodimerize (By similarity). Part of the multisubunit TRAPP (transport protein particle) complex. Interacts with ENO1 and TRAPPC2L.By similarity3 Publications

Protein-protein interaction databases

BioGridi112299, 42 interactors
IntActiP0DI82, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliP0DI82
SMRiP0DI82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3487 Eukaryota
COG5603 LUCA
GeneTreeiENSGT00510000047168
InParanoidiP0DI82
KOiK20301
OrthoDBiEOG091G01AJ
PhylomeDBiP0DI82
TreeFamiTF314814

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR006722 Sedlin
PANTHERiPTHR12403 PTHR12403, 1 hit
PfamiView protein in Pfam
PF04628 Sedlin_N, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit

Sequencei

Sequence statusi: Complete.

P0DI82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGSFYFVIV GHHDNPVFEM EFLPAGKAES KDDHRHLNQF IAHAALDLVD
60 70 80 90 100
ENMWLSNNMY LKTVDKFNEW FVSAFVTAGH MRFIMLHDIR QEDGIKNFFT
110 120 130 140
DVYDLYIKFS MNPFYEPNSP IRSSAFDRKV QFLGKKHLLS
Length:140
Mass (Da):16,445
Last modified:September 21, 2011 - v1
Checksum:iB099943C6F88952C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105L → P in AAG02469 (PubMed:11134351).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291676 mRNA Translation: AAG02469.1
AF058918 mRNA Translation: AAC14421.1
AC003002 Genomic DNA Translation: AAB80684.1
BC008889 mRNA No translation available.
BC032809 mRNA No translation available.
CCDSiCCDS86812.1
RefSeqiNP_001011658.1, NM_001011658.3
NP_055378.1, NM_014563.5
XP_011543867.1, XM_011545565.1
XP_011543868.1, XM_011545566.2
UniGeneiHs.446620
Hs.592238
Hs.622292

Genome annotation databases

EnsembliENST00000543226; ENSP00000442778; ENSG00000256060
ENST00000596755; ENSP00000469888; ENSG00000256060
GeneIDi6399
KEGGihsa:6399

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291676 mRNA Translation: AAG02469.1
AF058918 mRNA Translation: AAC14421.1
AC003002 Genomic DNA Translation: AAB80684.1
BC008889 mRNA No translation available.
BC032809 mRNA No translation available.
CCDSiCCDS86812.1
RefSeqiNP_001011658.1, NM_001011658.3
NP_055378.1, NM_014563.5
XP_011543867.1, XM_011545565.1
XP_011543868.1, XM_011545566.2
UniGeneiHs.446620
Hs.592238
Hs.622292

3D structure databases

ProteinModelPortaliP0DI82
SMRiP0DI82
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112299, 42 interactors
IntActiP0DI82, 2 interactors

PTM databases

iPTMnetiP0DI82

Polymorphism and mutation databases

DMDMi347662478

Proteomic databases

EPDiP0DI82
PRIDEiP0DI82
ProteomicsDBi52534

Protocols and materials databases

DNASUi6399
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000543226; ENSP00000442778; ENSG00000256060
ENST00000596755; ENSP00000469888; ENSG00000256060
GeneIDi6399
KEGGihsa:6399

Organism-specific databases

CTDi6399
DisGeNETi10597
6399
EuPathDBiHostDB:ENSG00000256060.2
GeneCardsiTRAPPC2B
HGNCiHGNC:10710 TRAPPC2B
HPAiHPA063308
neXtProtiNX_P0DI82
OpenTargetsiENSG00000196459
ENSG00000256060
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3487 Eukaryota
COG5603 LUCA
GeneTreeiENSGT00510000047168
InParanoidiP0DI82
KOiK20301
OrthoDBiEOG091G01AJ
PhylomeDBiP0DI82
TreeFamiTF314814

Miscellaneous databases

GenomeRNAii6399
PROiPR:P0DI82

Gene expression databases

BgeeiENSG00000256060 Expressed in 90 organ(s), highest expression level in right adrenal gland
CleanExiHS_TRAPPC2
ExpressionAtlasiP0DI82 baseline and differential
GenevisibleiP0DI82 HS

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR006722 Sedlin
PANTHERiPTHR12403 PTHR12403, 1 hit
PfamiView protein in Pfam
PF04628 Sedlin_N, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPC2B_HUMAN
AccessioniPrimary (citable) accession number: P0DI82
Secondary accession number(s): A6NEG0, O14582, Q9HD16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 7, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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