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Entry version 70 (16 Oct 2019)
Sequence version 1 (21 Sep 2011)
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Protein

Trafficking protein particle complex subunit 2

Gene

TRAPPC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi.By similarity

Miscellaneous

A paralogous gene encoding an identical protein appears to have arisen by retrotransposition of a cDNA from this locus and to have acquired a promoter and non-coding 5' UTR from the ZNF547 gene.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Transcription, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trafficking protein particle complex subunit 2
Alternative name(s):
Sedlin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAPPC2
Synonyms:SEDL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23068 TRAPPC2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300202 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P0DI81

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spondyloepiphyseal dysplasia tarda (SEDT)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionX-linked recessive disorder of endochondral bone formation.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01235847D → Y in SEDT; loss-of-function mutation. 3 Publications1
Natural variantiVAR_01235973S → L in SEDT; loss of interaction with ENO1, PITX1 and SF1. 2 PublicationsCorresponds to variant dbSNP:rs769218264Ensembl.1
Natural variantiVAR_01236183F → S in SEDT; mild form; loss of interaction with ENO1, PITX1 and SF1. 2 PublicationsCorresponds to variant dbSNP:rs104894948EnsemblClinVar.1
Natural variantiVAR_012360130V → D in SEDT; loss of interaction with ENO1, PITX1 and SF1. 2 Publications1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
10597
6399

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
TRAPPC2

MalaCards human disease database

More...
MalaCardsi
TRAPPC2
MIMi313400 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000196459
ENSG00000256060

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
93284 Spondyloepiphyseal dysplasia tarda

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P0DI81

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRAPPC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
347662477

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002115661 – 140Trafficking protein particle complex subunit 2Add BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei119PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0DI81

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P0DI81

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0DI81

PeptideAtlas

More...
PeptideAtlasi
P0DI81

PRoteomics IDEntifications database

More...
PRIDEi
P0DI81

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52531
52532 [P0DI81-2]
52533 [P0DI81-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P0DI81-1 [P0DI81-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0DI81

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P0DI81

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, fetal cartilage, fibroblasts, placenta and lymphocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196459 Expressed in 221 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P0DI81 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P0DI81 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004665
HPA063308

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can homodimerize.

Component of the multisubunit TRAPP (transport protein particle) complex, which includes TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.

Interacts with ENO1, PITX1 and SF1.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112299, 81 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P0DI81

Protein interaction database and analysis system

More...
IntActi
P0DI81, 44 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000392495

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0DI81

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3487 Eukaryota
COG5603 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164401

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0DI81

KEGG Orthology (KO)

More...
KOi
K20301

Identification of Orthologs from Complete Genome Data

More...
OMAi
NPIFEME

Database of Orthologous Groups

More...
OrthoDBi
1426075at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0DI81

TreeFam database of animal gene trees

More...
TreeFami
TF314814

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011012 Longin-like_dom_sf
IPR006722 Sedlin

The PANTHER Classification System

More...
PANTHERi
PTHR12403 PTHR12403, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04628 Sedlin_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF64356 SSF64356, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P0DI81-1) [UniParc]FASTAAdd to basket
Also known as: Major

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGSFYFVIV GHHDNPVFEM EFLPAGKAES KDDHRHLNQF IAHAALDLVD
60 70 80 90 100
ENMWLSNNMY LKTVDKFNEW FVSAFVTAGH MRFIMLHDIR QEDGIKNFFT
110 120 130 140
DVYDLYIKFS MNPFYEPNSP IRSSAFDRKV QFLGKKHLLS
Length:140
Mass (Da):16,445
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB099943C6F88952C
GO
Isoform 2 (identifier: P0DI81-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSSWKQDRSGLRSTELNVLEYQPLCAVRSHILKTM
     80-80: H → HILTFLVKVTN
     81-140: Missing.

Show »
Length:124
Mass (Da):14,275
Checksum:i753235EC5EC7DB78
GO
Isoform 3 (identifier: P0DI81-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSSWKQDRSGLRSTELNVLEYQPLCAVRSHILKTM

Show »
Length:174
Mass (Da):20,374
Checksum:i6C107891FCD4AE37
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H785F5H785_HUMAN
Trafficking protein particle comple...
TRAPPC2
113Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFG0E5RFG0_HUMAN
Trafficking protein particle comple...
TRAPPC2
74Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01235847D → Y in SEDT; loss-of-function mutation. 3 Publications1
Natural variantiVAR_01235973S → L in SEDT; loss of interaction with ENO1, PITX1 and SF1. 2 PublicationsCorresponds to variant dbSNP:rs769218264Ensembl.1
Natural variantiVAR_01236183F → S in SEDT; mild form; loss of interaction with ENO1, PITX1 and SF1. 2 PublicationsCorresponds to variant dbSNP:rs104894948EnsemblClinVar.1
Natural variantiVAR_012360130V → D in SEDT; loss of interaction with ENO1, PITX1 and SF1. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0416811M → MSSWKQDRSGLRSTELNVLE YQPLCAVRSHILKTM in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_00604080H → HILTFLVKVTN in isoform 2. 1 Publication1
Alternative sequenceiVSP_04168281 – 140Missing in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF157065
, AF157062, AF157063, AF157064 Genomic DNA Translation: AAD49845.1
AC003037 Genomic DNA No translation available.
AK310542 mRNA No translation available.
DA542477 mRNA No translation available.
DB101396 mRNA No translation available.
BC016915 mRNA Translation: AAH16915.1
BC052618 mRNA Translation: AAH52618.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48082.1
CCDS48083.2 [P0DI81-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001011658.1, NM_001011658.3 [P0DI81-1]
NP_001122307.2, NM_001128835.2 [P0DI81-3]
NP_055378.1, NM_014563.5 [P0DI81-1]
XP_011543867.1, XM_011545565.1 [P0DI81-1]
XP_011543868.1, XM_011545566.2 [P0DI81-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000359680; ENSP00000352708; ENSG00000196459 [P0DI81-1]
ENST00000380579; ENSP00000369953; ENSG00000196459 [P0DI81-1]
ENST00000458511; ENSP00000392495; ENSG00000196459 [P0DI81-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6399

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6399

UCSC genome browser

More...
UCSCi
uc064yav.1 human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157065
, AF157062, AF157063, AF157064 Genomic DNA Translation: AAD49845.1
AC003037 Genomic DNA No translation available.
AK310542 mRNA No translation available.
DA542477 mRNA No translation available.
DB101396 mRNA No translation available.
BC016915 mRNA Translation: AAH16915.1
BC052618 mRNA Translation: AAH52618.1
CCDSiCCDS48082.1
CCDS48083.2 [P0DI81-3]
RefSeqiNP_001011658.1, NM_001011658.3 [P0DI81-1]
NP_001122307.2, NM_001128835.2 [P0DI81-3]
NP_055378.1, NM_014563.5 [P0DI81-1]
XP_011543867.1, XM_011545565.1 [P0DI81-1]
XP_011543868.1, XM_011545566.2 [P0DI81-1]

3D structure databases

SMRiP0DI81
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112299, 81 interactors
CORUMiP0DI81
IntActiP0DI81, 44 interactors
STRINGi9606.ENSP00000392495

PTM databases

iPTMnetiP0DI81
PhosphoSitePlusiP0DI81

Polymorphism and mutation databases

BioMutaiTRAPPC2
DMDMi347662477

Proteomic databases

jPOSTiP0DI81
MassIVEiP0DI81
PaxDbiP0DI81
PeptideAtlasiP0DI81
PRIDEiP0DI81
ProteomicsDBi52531
52532 [P0DI81-2]
52533 [P0DI81-3]
TopDownProteomicsiP0DI81-1 [P0DI81-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6399

Genome annotation databases

EnsembliENST00000359680; ENSP00000352708; ENSG00000196459 [P0DI81-1]
ENST00000380579; ENSP00000369953; ENSG00000196459 [P0DI81-1]
ENST00000458511; ENSP00000392495; ENSG00000196459 [P0DI81-3]
GeneIDi6399
KEGGihsa:6399
UCSCiuc064yav.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6399
DisGeNETi10597
6399

GeneCards: human genes, protein and diseases

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GeneCardsi
TRAPPC2
GeneReviewsiTRAPPC2
HGNCiHGNC:23068 TRAPPC2
HPAiCAB004665
HPA063308
MalaCardsiTRAPPC2
MIMi300202 gene
313400 phenotype
neXtProtiNX_P0DI81
OpenTargetsiENSG00000196459
ENSG00000256060
Orphaneti93284 Spondyloepiphyseal dysplasia tarda

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3487 Eukaryota
COG5603 LUCA
GeneTreeiENSGT00940000164401
InParanoidiP0DI81
KOiK20301
OMAiNPIFEME
OrthoDBi1426075at2759
PhylomeDBiP0DI81
TreeFamiTF314814

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRAPPC2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TRAPPC2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6399
PharosiP0DI81

Protein Ontology

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PROi
PR:P0DI81

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000196459 Expressed in 221 organ(s), highest expression level in forebrain
ExpressionAtlasiP0DI81 baseline and differential
GenevisibleiP0DI81 HS

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR006722 Sedlin
PANTHERiPTHR12403 PTHR12403, 1 hit
PfamiView protein in Pfam
PF04628 Sedlin_N, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPC2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0DI81
Secondary accession number(s): A6NEG0, O14582, Q9HD16
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: September 21, 2011
Last modified: October 16, 2019
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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