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UniProtKB - P0DH95 (CALM1_ARATH)
Protein
Calmodulin-1
Gene
CAM1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.
Miscellaneous
This protein has four functional calcium-binding sites.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 21 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 23 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 25 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 27 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 32 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 57 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 59 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 61 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 63 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 68 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 94 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 96 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 98 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 105 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 130 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 132 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 134 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 136 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 141 | Calcium 4PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- calcium ion binding Source: GO_Central
Keywordsi
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Calmodulin-1Short name: CaM-1 |
Gene namesi | Name:CAM1 Ordered Locus Names:At5g37780 ORF Names:K22F20.2, T31G3.3 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT5G37780 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Plasma membrane
- Cell membrane 1 Publication
Note: Localizes to the plasma membrane when interacting with ZAR1.1 Publication
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000415789 | 1 – 149 | Calmodulin-1Add BLAST | 149 |
Proteomic databases
PRIDEi | P0DH95 |
PTM databases
iPTMneti | P0DH95 |
Expressioni
Gene expression databases
ExpressionAtlasi | P0DH95, baseline and differential |
Genevisiblei | P0DH95, AT |
Interactioni
Subunit structurei
Protein-protein interaction databases
BioGRIDi | 19007, 143 interactors 28180, 3 interactors |
STRINGi | 3702.AT1G66410.2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 43 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 44 – 79 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 81 – 116 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 117 – 149 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 33 |
Sequence similaritiesi
Belongs to the calmodulin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
HOGENOMi | CLU_061288_2_0_1 |
InParanoidi | P0DH95 |
OMAi | HPEATHA |
PhylomeDBi | P0DH95 |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry describes 1 produced by isoform ialternative splicing. AlignAdd to basketNote: A number of isoforms are produced. According to EST sequences.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P0DH95-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADQLTDEQI SEFKEAFSLF DKDGDGCITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL NLMAKKMKDT DSEEELKEAF RVFDKDQNGF
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVEEMIREAD VDGDGQINYE EFVKIMMAK
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF4K8M2 | F4K8M2_ARATH | Calmodulin 1 | CAM1 ACAM-1, calmodulin 1, TCH1, TOUCH 1, At5g37780 | 175 | Annotation score: | ||
F4IEU4 | F4IEU4_ARATH | Calmodulin 4 | CAM4 ACAM-4, CALMODULIN 4, calmodulin 4, At1g66410, T27F4.1 | 159 | Annotation score: | ||
A0A1P8BAP4 | A0A1P8BAP4_ARATH | Calmodulin 1 | CAM1 ACAM-1, calmodulin 1, TCH1, TOUCH 1, At5g37780 | 136 | Annotation score: | ||
F4K8M3 | F4K8M3_ARATH | Calmodulin 1 | CAM1 ACAM-1, calmodulin 1, TCH1, TOUCH 1, At5g37780 | 164 | Annotation score: | ||
A0A1P8ANC4 | A0A1P8ANC4_ARATH | Calmodulin 4 | CAM4 ACAM-4, CALMODULIN 4, calmodulin 4, At1g66410, T27F4.1 | 113 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB016873 Genomic DNA Translation: BAB10354.1 AB026662 Genomic DNA No translation available. CP002688 Genomic DNA Translation: AED94230.1 AY059809 mRNA Translation: AAL24291.1 AY048276 mRNA Translation: AAK82538.1 AY072520 mRNA Translation: AAL66935.1 AY072628 mRNA Translation: AAL62019.1 M38379 mRNA Translation: AAA32762.1 |
PIRi | T50929 |
RefSeqi | NP_176814.1, NM_105312.4 [P0DH95-1] NP_198594.1, NM_123137.4 [P0DH95-1] |
Genome annotation databases
EnsemblPlantsi | AT1G66410.1; AT1G66410.1; AT1G66410 [P0DH95-1] AT5G37780.1; AT5G37780.1; AT5G37780 [P0DH95-1] |
GeneIDi | 833756 842959 |
Gramenei | AT1G66410.1; AT1G66410.1; AT1G66410 [P0DH95-1] AT5G37780.1; AT5G37780.1; AT5G37780 [P0DH95-1] |
KEGGi | ath:AT1G66410 ath:AT5G37780 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB016873 Genomic DNA Translation: BAB10354.1 AB026662 Genomic DNA No translation available. CP002688 Genomic DNA Translation: AED94230.1 AY059809 mRNA Translation: AAL24291.1 AY048276 mRNA Translation: AAK82538.1 AY072520 mRNA Translation: AAL66935.1 AY072628 mRNA Translation: AAL62019.1 M38379 mRNA Translation: AAA32762.1 |
PIRi | T50929 |
RefSeqi | NP_176814.1, NM_105312.4 [P0DH95-1] NP_198594.1, NM_123137.4 [P0DH95-1] |
3D structure databases
AlphaFoldDBi | P0DH95 |
SMRi | P0DH95 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 19007, 143 interactors 28180, 3 interactors |
STRINGi | 3702.AT1G66410.2 |
PTM databases
iPTMneti | P0DH95 |
Proteomic databases
PRIDEi | P0DH95 |
Genome annotation databases
EnsemblPlantsi | AT1G66410.1; AT1G66410.1; AT1G66410 [P0DH95-1] AT5G37780.1; AT5G37780.1; AT5G37780 [P0DH95-1] |
GeneIDi | 833756 842959 |
Gramenei | AT1G66410.1; AT1G66410.1; AT1G66410 [P0DH95-1] AT5G37780.1; AT5G37780.1; AT5G37780 [P0DH95-1] |
KEGGi | ath:AT1G66410 ath:AT5G37780 |
Organism-specific databases
Araporti | AT5G37780 |
Phylogenomic databases
HOGENOMi | CLU_061288_2_0_1 |
InParanoidi | P0DH95 |
OMAi | HPEATHA |
PhylomeDBi | P0DH95 |
Miscellaneous databases
PROi | PR:P0DH95 |
Gene expression databases
ExpressionAtlasi | P0DH95, baseline and differential |
Genevisiblei | P0DH95, AT |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CALM1_ARATH | |
Accessioni | P0DH95Primary (citable) accession number: P0DH95 Secondary accession number(s): P25854, Q03510, Q9FJ05 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | May 25, 2022 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families