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Protein

Kappa-conotoxin-like Bu27

Gene
N/A
Organism
Conus bullatus (Bubble cone)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Kappa-conotoxins bind and inhibit voltage-gated potassium channels.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-conotoxin-like Bu27
OrganismiConus bullatus (Bubble cone)
Taxonomic identifieri89438 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusTextilia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000409979‹1 – 12By similarityAdd BLAST›12
PeptideiPRO_000040998013 – 48Kappa-conotoxin-like Bu27Add BLAST36
PropeptideiPRO_000040998149 – 53By similarity5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei144-hydroxyprolineBy similarity1
Modified residuei154-carboxyglutamateBy similarity1
Modified residuei294-hydroxyprolineBy similarity1
Modified residuei344-hydroxyprolineBy similarity1
Modified residuei354-hydroxyprolineBy similarity1
Modified residuei434-hydroxyprolineBy similarity1
Modified residuei444-hydroxyprolineBy similarity1
Modified residuei484-hydroxyprolineBy similarity1
Modified residuei48Proline amideBy similarity1

Post-translational modificationi

Contains 3 disulfide bonds (By similarity). They are not indicated here, since framework IV presents two different connectivities (I-V, II-III, IV-VI and I-III, II-V, IV-VI).By similarity

Keywords - PTMi

Amidation, Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiP0CY82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is IV (CC-C-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CY82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ASDGRNAVVH ERAPELVVTA TTTCCGYDPM TICPPCMCTH SCPPKRKPGR

RND
Length:53
Mass (Da):5,745
Last modified:June 28, 2011 - v1
Checksum:i51299FA61D1EE0C2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Similar proteinsi

Cross-referencesi

3D structure databases

SMRiP0CY82
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCA427_CONBU
AccessioniPrimary (citable) accession number: P0CY82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 12, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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