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Protein

60S ribosomal protein L19-A

Gene

RPL19A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eL19 may play a role in the last stages of translation initiation, in particular sububit joining and shedding/releasing factors.1 Publication

Miscellaneous

Present with 97700 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eL19 in yeast.Curated

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-29228-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L19-A1 Publication
Alternative name(s):
L23
Large ribosomal subunit protein eL19-A1 Publication
RP15L
RP33
YL14
Gene namesi
Name:RPL19A1 Publication
Synonyms:RPL23A, YL14A
Ordered Locus Names:YBR084C-A
ORF Names:YBR084BC
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

SGDiS000002156 RPL19A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1741172

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001311842 – 18960S ribosomal protein L19-AAdd BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei30PhosphoserineCombined sources1
Modified residuei37PhosphoserineCombined sources1
Cross-linki53Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki60Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei91PhosphoserineCombined sources1
Cross-linki146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki186Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP0CX82
PaxDbiP0CX82
PRIDEiP0CX82
TopDownProteomicsiP0CX82

PTM databases

CarbonylDBiP0CX82
iPTMnetiP0CX82

Expressioni

Gene expression databases

ExpressionAtlasiP0CX82 differential

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). eL19 lies in close proximity to the binding site for eukaryotic initiation factor eIF4G (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi32671, 279 interactors
32789, 125 interactors
IntActiP0CX82, 2 interactors
MINTiP0CX82
STRINGi4932.YBR084C-A

Chemistry databases

BindingDBiP0CX82

Structurei

Secondary structure

1189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 15Combined sources11
Helixi19 – 21Combined sources3
Beta strandi22 – 24Combined sources3
Helixi26 – 28Combined sources3
Helixi29 – 33Combined sources5
Helixi38 – 46Combined sources9
Beta strandi49 – 51Combined sources3
Helixi61 – 71Combined sources11
Turni72 – 75Combined sources4
Helixi78 – 80Combined sources3
Helixi85 – 88Combined sources4
Helixi91 – 110Combined sources20
Turni111 – 113Combined sources3
Helixi117 – 127Combined sources11
Beta strandi129 – 131Combined sources3
Beta strandi132 – 134Combined sources3
Helixi135 – 175Combined sources41
Turni176 – 178Combined sources3
Helixi183 – 186Combined sources4

3D structure databases

ProteinModelPortaliP0CX82
SMRiP0CX82
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CX82

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiP0CX82
KOiK02885
OMAiNRVWIDP
OrthoDBiEOG092C00Q9

Family and domain databases

CDDicd01417 Ribosomal_L19e_E, 1 hit
Gene3Di1.10.1650.10, 1 hit
HAMAPiMF_01475 Ribosomal_L19e, 1 hit
InterProiView protein in InterPro
IPR035970 60S_ribosomal_L19/L19e_sf
IPR000196 Ribosomal_L19/L19e
IPR023638 Ribosomal_L19/L19e_CS
IPR015972 Ribosomal_L19/L19e_dom1
IPR033935 Ribosomal_L19_euka
PfamiView protein in Pfam
PF01280 Ribosomal_L19e, 1 hit
SMARTiView protein in SMART
SM01416 Ribosomal_L19e, 1 hit
SUPFAMiSSF48140 SSF48140, 1 hit
PROSITEiView protein in PROSITE
PS00526 RIBOSOMAL_L19E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CX82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLRTQKRL AASVVGVGKR KVWLDPNETS EIAQANSRNA IRKLVKNGTI
60 70 80 90 100
VKKAVTVHSK SRTRAHAQSK REGRHSGYGK RKGTREARLP SQVVWIRRLR
110 120 130 140 150
VLRRLLAKYR DAGKIDKHLY HVLYKESKGN AFKHKRALVE HIIQAKADAQ
160 170 180
REKALNEEAE ARRLKNRAAR DRRAQRVAEK RDALLKEDA
Length:189
Mass (Da):21,704
Last modified:June 28, 2011 - v1
Checksum:i776C3AB3D348EE99
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54A → S in J03724 (PubMed:2836393).Curated1

Mass spectrometryi

Molecular mass is 21573.159 Da from positions 2 - 189. Determined by ESI. Average mass.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36751 Genomic DNA Translation: CAA85322.1
D17337 mRNA Translation: BAA04155.1
Z35953 Genomic DNA Translation: CAA85030.1
Z35954 Genomic DNA Translation: CAA85032.1
J03724 Genomic DNA No translation available.
BK006936 Genomic DNA Translation: DAA07204.1
PIRiS44597
RefSeqiNP_009526.1, NM_001178267.1
NP_009641.1, NM_001180057.1

Genome annotation databases

EnsemblFungiiYBL027W; YBL027W; YBL027W
YBR084C-A; YBR084C-A; YBR084C-A
GeneIDi852254
852379
KEGGisce:YBL027W
sce:YBR084C-A

Similar proteinsi

Entry informationi

Entry nameiRL19A_YEAST
AccessioniPrimary (citable) accession number: P0CX82
Secondary accession number(s): D6VPX3, P05735
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: July 18, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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