UniProtKB - P0CX51 (RS16A_YEAST)
Protein
40S ribosomal protein S16-A
Gene
RPS16A
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication
Miscellaneous
Present with 33800 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for uS9 in yeast.Curated
GO - Molecular functioni
- RNA binding Source: GO_Central
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- cytoplasmic translation Source: SGD
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
Reactomei | R-SCE-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-SCE-1799339, SRP-dependent cotranslational protein targeting to membrane R-SCE-72689, Formation of a pool of free 40S subunits R-SCE-72695, Formation of the ternary complex, and subsequently, the 43S complex R-SCE-72702, Ribosomal scanning and start codon recognition R-SCE-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-SCE-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-SCE-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 40S ribosomal protein S16-A1 PublicationAlternative name(s): RP61R Small ribosomal subunit protein uS9-A1 Publication |
Gene namesi | Ordered Locus Names:YMR143W ORF Names:YM9375.12 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004751, RPS16A |
Subcellular locationi
Other locations
- Cytoplasm 2 Publications
Cytosol
- cytosolic small ribosomal subunit Source: GO_Central
Other locations
- 90S preribosome Source: SGD
- small ribosomal subunit Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed2 Publications | |||
ChainiPRO_0000111503 | 2 – 143 | 40S ribosomal protein S16-AAdd BLAST | 142 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserine2 Publications | 1 | |
Cross-linki | 30 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources | ||
Modified residuei | 34 | PhosphoserineCombined sources | 1 | |
Cross-linki | 47 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources | ||
Cross-linki | 59 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources | ||
Modified residuei | 61 | PhosphoserineCombined sources | 1 | |
Modified residuei | 70 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 76 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P0CX51 |
PaxDbi | P0CX51 |
PRIDEi | P0CX51 |
TopDownProteomicsi | P0CX51 |
PTM databases
CarbonylDBi | P0CX51 |
iPTMneti | P0CX51 |
Interactioni
Subunit structurei
Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
1 Publication1 PublicationProtein-protein interaction databases
BioGRIDi | 31978, 279 interactors 35319, 289 interactors |
IntActi | P0CX51, 2 interactors |
MINTi | P0CX51 |
STRINGi | 4932.YMR143W |
Miscellaneous databases
RNActi | P0CX51, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0CX51 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0CX51 |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uS9 family.Curated
Phylogenomic databases
eggNOGi | KOG1753, Eukaryota |
HOGENOMi | CLU_046483_4_0_1 |
InParanoidi | P0CX51 |
OMAi | FMGQAEA |
Family and domain databases
Gene3Di | 3.30.230.10, 1 hit |
InterProi | View protein in InterPro IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr IPR000754, Ribosomal_S9 IPR020574, Ribosomal_S9_CS |
PANTHERi | PTHR21569, PTHR21569, 1 hit |
Pfami | View protein in Pfam PF00380, Ribosomal_S9, 1 hit |
SUPFAMi | SSF54211, SSF54211, 1 hit |
PROSITEi | View protein in PROSITE PS00360, RIBOSOMAL_S9, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0CX51-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAVPSVQTF GKKKSATAVA HVKAGKGLIK VNGSPITLVE PEILRFKVYE
60 70 80 90 100
PLLLVGLDKF SNIDIRVRVT GGGHVSQVYA IRQAIAKGLV AYHQKYVDEQ
110 120 130 140
SKNELKKAFT SYDRTLLIAD SRRPEPKKFG GKGARSRFQK SYR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z47071 Genomic DNA Translation: CAA87357.1 BK006946 Genomic DNA Translation: DAA10039.1 |
PIRi | S67619 |
RefSeqi | NP_010200.1, NM_001180142.1 NP_013863.2, NM_001182645.1 |
Genome annotation databases
EnsemblFungii | YDL083C_mRNA; YDL083C; YDL083C YMR143W_mRNA; YMR143W; YMR143W |
GeneIDi | 851476 855174 |
KEGGi | sce:YDL083C sce:YMR143W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z47071 Genomic DNA Translation: CAA87357.1 BK006946 Genomic DNA Translation: DAA10039.1 |
PIRi | S67619 |
RefSeqi | NP_010200.1, NM_001180142.1 NP_013863.2, NM_001182645.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1K5X | model | - | I | 5-143 | [»] | |
3J6X | electron microscopy | 6.10 | 16 | 1-143 | [»] | |
3J6Y | electron microscopy | 6.10 | 16 | 1-143 | [»] | |
3J77 | electron microscopy | 6.20 | 16 | 1-143 | [»] | |
3J78 | electron microscopy | 6.30 | 16 | 1-143 | [»] | |
4U3M | X-ray | 3.00 | C6/c6 | 2-143 | [»] | |
4U3N | X-ray | 3.20 | C6/c6 | 2-143 | [»] | |
4U3U | X-ray | 2.90 | C6/c6 | 2-143 | [»] | |
4U4N | X-ray | 3.10 | C6/c6 | 2-143 | [»] | |
4U4O | X-ray | 3.60 | C6/c6 | 2-143 | [»] | |
4U4Q | X-ray | 3.00 | C6/c6 | 2-143 | [»] | |
4U4R | X-ray | 2.80 | C6/c6 | 2-143 | [»] | |
4U4U | X-ray | 3.00 | C6/c6 | 2-143 | [»] | |
4U4Y | X-ray | 3.20 | C6/c6 | 2-143 | [»] | |
4U4Z | X-ray | 3.10 | C6/c6 | 2-143 | [»] | |
4U50 | X-ray | 3.20 | C6/c6 | 2-143 | [»] | |
4U51 | X-ray | 3.20 | C6/c6 | 2-143 | [»] | |
4U52 | X-ray | 3.00 | C6/c6 | 2-143 | [»] | |
4U53 | X-ray | 3.30 | C6/c6 | 2-143 | [»] | |
4U55 | X-ray | 3.20 | C6/c6 | 2-143 | [»] | |
4U56 | X-ray | 3.45 | C6/c6 | 2-143 | [»] | |
4U6F | X-ray | 3.10 | C6/c6 | 2-143 | [»] | |
4V4B | electron microscopy | 11.70 | AI | 2-143 | [»] | |
4V6I | electron microscopy | 8.80 | AI | 1-143 | [»] | |
4V7R | X-ray | 4.00 | AJ/CJ | 1-143 | [»] | |
4V88 | X-ray | 3.00 | AQ/CQ | 1-143 | [»] | |
4V8Y | electron microscopy | 4.30 | AQ | 1-143 | [»] | |
4V8Z | electron microscopy | 6.60 | AQ | 1-143 | [»] | |
4V92 | electron microscopy | 3.70 | Q | 3-142 | [»] | |
5DAT | X-ray | 3.15 | C6/c6 | 2-143 | [»] | |
5DC3 | X-ray | 3.25 | C6/c6 | 2-143 | [»] | |
5DGE | X-ray | 3.45 | C6/c6 | 2-143 | [»] | |
5DGF | X-ray | 3.30 | C6/c6 | 2-143 | [»] | |
5DGV | X-ray | 3.10 | C6/c6 | 2-143 | [»] | |
5FCI | X-ray | 3.40 | C6/c6 | 2-143 | [»] | |
5FCJ | X-ray | 3.10 | C6/c6 | 2-143 | [»] | |
5I4L | X-ray | 3.10 | C6/c6 | 2-143 | [»] | |
5JPQ | electron microscopy | 7.30 | x | 1-143 | [»] | |
5JUO | electron microscopy | 4.00 | NB | 1-143 | [»] | |
5JUP | electron microscopy | 3.50 | NB | 1-143 | [»] | |
5JUS | electron microscopy | 4.20 | NB | 1-143 | [»] | |
5JUT | electron microscopy | 4.00 | NB | 1-143 | [»] | |
5JUU | electron microscopy | 4.00 | NB | 1-143 | [»] | |
5LYB | X-ray | 3.25 | C6/c6 | 2-143 | [»] | |
5M1J | electron microscopy | 3.30 | Q2 | 3-143 | [»] | |
5MC6 | electron microscopy | 3.80 | F | 1-143 | [»] | |
5MEI | X-ray | 3.50 | R/c6 | 2-143 | [»] | |
5NDG | X-ray | 3.70 | C6/c6 | 3-143 | [»] | |
5NDV | X-ray | 3.30 | C6/c6 | 2-143 | [»] | |
5NDW | X-ray | 3.70 | C6/c6 | 3-143 | [»] | |
5OBM | X-ray | 3.40 | C6/c6 | 2-143 | [»] | |
5ON6 | X-ray | 3.10 | R/c6 | 2-143 | [»] | |
5TBW | X-ray | 3.00 | R/c6 | 2-143 | [»] | |
5TGA | X-ray | 3.30 | C6/c6 | 2-143 | [»] | |
5TGM | X-ray | 3.50 | C6/c6 | 2-143 | [»] | |
5TZS | electron microscopy | 5.10 | C | 1-143 | [»] | |
5WLC | electron microscopy | 3.80 | LC | 1-143 | [»] | |
5WYJ | electron microscopy | 8.70 | SR | 1-143 | [»] | |
5WYK | electron microscopy | 4.50 | SR | 1-143 | [»] | |
6EML | electron microscopy | 3.60 | F | 1-143 | [»] | |
6FAI | electron microscopy | 3.40 | Q | 1-143 | [»] | |
6GQ1 | electron microscopy | 4.40 | AG | 3-143 | [»] | |
6GQB | electron microscopy | 3.90 | AG | 3-143 | [»] | |
6GQV | electron microscopy | 4.00 | AG | 3-143 | [»] | |
6HHQ | X-ray | 3.10 | R/c6 | 1-143 | [»] | |
6I7O | electron microscopy | 5.30 | F/Fb | 3-143 | [»] | |
6KE6 | electron microscopy | 3.40 | SR | 1-143 | [»] | |
6Q8Y | electron microscopy | 3.10 | F | 3-143 | [»] | |
6RBD | electron microscopy | 3.47 | Q | 1-143 | [»] | |
6RBE | electron microscopy | 3.80 | Q | 1-143 | [»] | |
6S47 | electron microscopy | 3.28 | BR | 2-143 | [»] | |
6SNT | electron microscopy | 2.80 | Q | 1-143 | [»] | |
6SV4 | electron microscopy | 3.30 | F/Fb/Fc | 1-143 | [»] | |
6T4Q | electron microscopy | 2.60 | SQ | 3-143 | [»] | |
6T7I | electron microscopy | 3.20 | SQ | 1-143 | [»] | |
6T7T | electron microscopy | 3.10 | SQ | 1-143 | [»] | |
6T83 | electron microscopy | 4.00 | Qb/r | 1-143 | [»] | |
6TB3 | electron microscopy | 2.80 | F | 3-143 | [»] | |
6TNU | electron microscopy | 3.10 | F | 3-143 | [»] | |
6XIQ | electron microscopy | 4.20 | AG | 1-143 | [»] | |
6XIR | electron microscopy | 3.20 | AG | 1-143 | [»] | |
6Y7C | electron microscopy | 3.80 | Q | 1-143 | [»] | |
6Z6J | electron microscopy | 3.40 | SQ | 1-143 | [»] | |
6Z6K | electron microscopy | 3.40 | SQ | 1-143 | [»] | |
6ZVI | electron microscopy | 3.00 | y | 3-143 | [»] | |
SMRi | P0CX51 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 31978, 279 interactors 35319, 289 interactors |
IntActi | P0CX51, 2 interactors |
MINTi | P0CX51 |
STRINGi | 4932.YMR143W |
PTM databases
CarbonylDBi | P0CX51 |
iPTMneti | P0CX51 |
Proteomic databases
MaxQBi | P0CX51 |
PaxDbi | P0CX51 |
PRIDEi | P0CX51 |
TopDownProteomicsi | P0CX51 |
Genome annotation databases
EnsemblFungii | YDL083C_mRNA; YDL083C; YDL083C YMR143W_mRNA; YMR143W; YMR143W |
GeneIDi | 851476 855174 |
KEGGi | sce:YDL083C sce:YMR143W |
Organism-specific databases
SGDi | S000004751, RPS16A |
Phylogenomic databases
eggNOGi | KOG1753, Eukaryota |
HOGENOMi | CLU_046483_4_0_1 |
InParanoidi | P0CX51 |
OMAi | FMGQAEA |
Enzyme and pathway databases
Reactomei | R-SCE-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-SCE-1799339, SRP-dependent cotranslational protein targeting to membrane R-SCE-72689, Formation of a pool of free 40S subunits R-SCE-72695, Formation of the ternary complex, and subsequently, the 43S complex R-SCE-72702, Ribosomal scanning and start codon recognition R-SCE-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-SCE-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-SCE-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
EvolutionaryTracei | P0CX51 |
PROi | PR:P0CX51 |
RNActi | P0CX51, protein |
Gene expression databases
ExpressionAtlasi | P0CX51, differential |
Family and domain databases
Gene3Di | 3.30.230.10, 1 hit |
InterProi | View protein in InterPro IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr IPR000754, Ribosomal_S9 IPR020574, Ribosomal_S9_CS |
PANTHERi | PTHR21569, PTHR21569, 1 hit |
Pfami | View protein in Pfam PF00380, Ribosomal_S9, 1 hit |
SUPFAMi | SSF54211, SSF54211, 1 hit |
PROSITEi | View protein in PROSITE PS00360, RIBOSOMAL_S9, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RS16A_YEAST | |
Accessioni | P0CX51Primary (citable) accession number: P0CX51 Secondary accession number(s): D6VRR6, P26787, P40213 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 28, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | December 2, 2020 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Ribosomal proteins
Ribosomal proteins families and list of entries